SPA0355 , CAS No.1251839-15-2

CAS: 1251839-15-2 Cat. No.: S1436152 Molecular Weight: 391.49 PubChem CID: 56593432

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs , Akt , and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CNC(=S)NC1=CC=C(C=C1)OCCN2C3=CC=CC=C3OC4=CC=CC=C42
• IUPAC Name: 1-methyl-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]thiourea
• InChIKey: IEFRKIYTMPORCY-UHFFFAOYSA-N
• INCHI: 1S/C22H21N3O2S/c1-23-22(28)24-16-10-12-17(13-11-16)26-15-14-25-18-6-2-4-8-20(18)27-21-9-5-3-7-19(21)25/h2-13H,14-15H2,1H3,(H2,23,24,28)
• Isomeric SMILES: CNC(=S)NC1=CC=C(C=C1)OCCN2C3=CC=CC=C3OC4=CC=CC=C42
• WGK Germany: 3
• PubChem CID: 56593432
• Molecular Weight: 391.49