STF-62247 - ≥98% , CAS No.315702-99-9

CAS: 315702-99-9 Cat. No.: S129300 Summenformel: C₁₅H₁₃N₃S Molekulargewicht: 267.35 EG-Nummer: 631-141-1 PubChem CID: 704473

GRADE & PURITY ≥98%

Synonyms

4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine | MFCD01121974 | KATNUHQNJGNLPW-UHFFFAOYSA-N | N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine | Oprea1_578909 | HMS3654K09 | DTXSID90351598 | J-018470 | SR-01000477178 | SR-01000477178-1 | SCHEMBL996232 | 4-(p

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

STF-62247 is TGN inhibitor with IC50 of 0.625μM and 16μM in RCC4 and RCC4/VHL cells,respectively.It specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC.
STF-62247 may be used as positive control in autophagy inducing cell signaling studies.

Specifications

Synonyme

4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine | MFCD01121974 | KATNUHQNJGNLPW-UHFFFAOYSA-N | N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine | Oprea1_578909 | HMS3654K09 | DTXSID90351598 | J-018470 | SR-01000477178 | SR-01000477178-1 | SCHEMBL996232 | 4-(p

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly red

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 528767214
• Kanonisches Lächeln: CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
• IUPAC Name: N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine
• InChIKey: KATNUHQNJGNLPW-UHFFFAOYSA-N
• INCHI: 1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
• Isomere SMILES: CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
• WGK Deutschland: 2
• PubChem CID: 704473
• Molekulargewicht: 267.35

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Aniline and substituted anilines

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Aniline and substituted anilines
• Intermediate Tree Nodes: Not available
• Direct Parent: Aniline and substituted anilines
• Alternative Parents: Toluenes 2,4-disubstituted thiazoles Pyridines and derivatives 2-amino-1,3-thiazoles Heteroaromatic compounds Secondary amines Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aniline or substituted anilines - 2,4-disubstituted 1,3-thiazole - Toluene - Pyridine - 1,3-thiazol-2-amine - Azole - Heteroaromatic compound - Thiazole - Secondary amine - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organonitrogen compound - Organopnictogen compound - Organic nitrogen compound - Amine - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as aniline and substituted anilines. These are organic compounds containing an aminobenzene moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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786-0 (47912 Activities)

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HepG2 (196354 Activities)

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HTT Tchem Huntingtin (19182 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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GMNN Tbio Geminin (128009 Activities)

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RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)

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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

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microRNA 21 (64692 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

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RCC4/VHL (23 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

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Hdac6 Histone deacetylase 6 (222 Activities)

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Plasmodium falciparum (966862 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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SARS-CoV-2 (38078 Activities)

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Vero C1008 (1716 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO 53 mg/mL Water <1 mg/mL Ethanol 3 mg/mL
• Brechungsindex: 1.67
• Siedepunkt (°C): 444.82° C
• Schmelzpunkt (°C): 174.66°C
• Molekulargewicht: 267.400 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 267.083 Da
• Monoisotopic Mass: 267.083 Da
• Topological Polar Surface Area: 66.100 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 281.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referenzen

1. Xuehua Long, Huiqi Wang, Jianqin Yan, Yifei Li, Xue Dong, Sijia Tian, Yong Sun, Kui Luo, Bin He, Yan Liang.  (2023)  Tailor-Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy.  Small,      [PMID:36932938] [10.1002/smll.202207898]