STL1267 - ≥99% , CAS No.1429024-58-7

CAS: 1429024-58-7 Cat. No.: S648879 Summenformel: C₁₇H₁₁ClN₄O Molekulargewicht: 322.75

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a K i value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1

In Vitro

STL1267 (5 µM; 24 h) decreases the expression of BMAL1 and increases the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a in HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HepG2, C2C12 cells Concentration: 0-20 µM Incubation Time: 24 h Result: Showed no adverse effects on cell viability up to the maximum dose examined 20 µM. RT-PCRCell Line: HepG2 cells Concentration: 5 µM Incubation Time: 24 h Result: Decreased the gene expression of BMAL1, increased the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a.

In Vivo

STL1267 (50 mg/kg; i.p.; once) inhibits Bmal1 expression in mouse . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 weeks, male C57Bl/6 J mice Dosage: 50 mg/kg Administration: I.p.; once Result: Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration.

Form:Solid

IC50& Target:K i : 0.16 µM (REV-ERBα)

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a K i value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Namen und Kennungen

• Kanonisches Lächeln: ClC1=NN=C2C=CC(OC3=C(C4=CC=CC=C4)C=CC=C3)=NN12
• Molekulargewicht: 322.75

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1429024-58-7, the molecular formula is C17H11ClN4O, and the molecular weight is 322.75 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.