Succinimidyl valeric acid PEG, mPEG-SVA - MW 1000 Da

Cat. No.: S164333

GRADE & PURITY MW 1000 Da

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol valeric acid (PEG-SVA) is an amino (-NH₂) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl valeric acid PEG (mPEG-SVA) offers superior reactivity yet higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

Specifications

Spezifikationen & Reinheit

MW 1000 Da

Biochemische und physiologische Mechanismen

Generally, a 10- to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

• Pegylation buffer: PBS buffer, pH 7.4 or other amine-free buffer at pH 7-8.5

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Chemische und physikalische Eigenschaften

• Löslichkeit: Off-white/white solid or viscous liquid depends on molecule weight;10 mg/mL, clear in water, DMSO, Chloroform
• Empfindlichkeit: Moisture sensitive.