TDI-10229 - ≥99% , CAS No.2810887-45-5

CAS: 2810887-45-5 Cat. No.: T648082 Summenformel: C₁₆H₁₆ClN₅ Molekulargewicht: 313.78

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10) . TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays ( IC 50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound

In Vitro

TDI-10229 exhibits good permeability with an IC 50 of 92 nM for human 4-4 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TDI-10229 (5 mg/kg; p.o.) treatment shows the C max , AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MouseDosage: 20 mg/kg Administration: P.o.(Pharmacokinetic Analysis) Result: The C max , AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.

Form:Solid

IC50& Target:IC 50 : 195 nM (sAC)

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10) . TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays ( IC 50 of 195 nM) and exhibits mouse pharmacokinetic properties suf

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Namen und Kennungen

Kanonisches Lächeln

CC1=C(C(C2=CC(Cl)=NC(N)=N2)=NN1C)CC3=CC=CC=C3

Molekulargewicht

313.78

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 125 mg/mL (398.37 mM; Need ultrasonic)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2810887-45-5, the molecular formula is C16H16ClN5, and the molecular weight is 313.78 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.