Terbinafine HCl - 10mM in DMSO , CAS No.78628-80-5

CAS: 78628-80-5 Cat. No.: T408464 Summenformel: C₂₁H₂₅N·HCl Molekulargewicht: 327.89 EG-Nummer: 691-642-6

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

KWD 2019 | N-​[(2E)​-​6,​6-​dimethyl-​2-​hepten-​4-​yn-​1-​yl]​-​N-​methyl-​1-​naphthalenemethanami​ne, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Terbinafine HCl Terbinafine HCl (KWD 201) inhibits ergosterol synthesis by inhibiting squalene epoxidase , used as an antifungal drug.
In vitro

Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Spezifikationen

Synonyme

KWD 2019 | N-​[(2E)​-​6,​6-​dimethyl-​2-​hepten-​4-​yn-​1-​yl]​-​N-​methyl-​1-​naphthalenemethanami​ne, hydrochloride (1:1)

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Terbinafine HCl (KWD 201) inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Isomere SMILES

CC(C)(C)C#C/C=C/CN(C)CC1=CC=CC2=CC=CC=C21.Cl

WGK Deutschland

3

RTECS

QJ8600100

Alternative CAS-Nummer

91161-71-6

NSC-Nummer

759113

MeSH-Eintrag

(E)-N-(6,6-dimethyl-2-heptenynyl)-N-methyl-1-naphthalenementhamin hydrochloride;DA 5505;Lamisil;SF 86 327;SF 86-327;SF 86327;SF-86-327;SF86327;TDT 067;TDT-067;TDT067;terbinafine;terbinafine hydrochloride;Terbinafine, (Z)-;terbinafine, (Z)-isomer

Molekulargewicht

327.89

Reaxy-Rn

31771739

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31771739&ln=

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 129 mg/mL (199.81 mM); Water: 129 mg/mL (199.81 mM); Ethanol: 8 mg/mL (12.39 mM)
• Siedepunkt (°C): 417.9° C at 760 mmHg
• Schmelzpunkt (°C): 214℃