TetrahydroCurcumin - 10mM in DMSO , CAS No.36062-04-1

CAS: 36062-04-1 Cat. No.: T580539 Summenformel: C₂₁H₂₄O₆ Molekulargewicht: 372.412 EG-Nummer: 609-201-3 PubChem CID: 124072

GRADE & PURITY 10mM in DMSO

Synonyms

EC 609-201-3 | 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-dione | 1,7-bis(4-hydroxy-3-methoxy-phenyl)heptane-3,5-dione | 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione | NSC 687845 | AS-13957 | FT-0661932 | NSC687845 | NSC-687845 | TETRAHYDRODI

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Tetrahydro Curcumin is a major metabolite of Curcumin that has been shown to have protective effects against diabetes and vascular dysfunction via alleviation of oxidative stress.

Specifications

Synonyme

EC 609-201-3 | 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-dione | 1,7-bis(4-hydroxy-3-methoxy-phenyl)heptane-3,5-dione | 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione | NSC 687845 | AS-13957 | FT-0661932 | NSC687845 | NSC-687845 | TETRAHYDRODI

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Tetrahydrocurcumin is being studied for the treatment of cancer and dementia. It has antioxidant and anti-inflammatory properties. Tetrahydrocurcumin has been shown to have protective effects against diabetes and vascular dysfunction via alleviation of ox

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Pubchem Sid

528771069

Kanonisches Lächeln

COC1=C(C=CC(=C1)CCC(=O)CC(=O)CCC2=CC(=C(C=C2)O)OC)O

IUPAC Name

1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione

InChIKey

LBTVHXHERHESKG-UHFFFAOYSA-N

INCHI

1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3

Isomere SMILES

COC1=C(C=CC(=C1)CCC(=O)CC(=O)CCC2=CC(=C(C=C2)O)OC)O

WGK Deutschland

3

PubChem CID

124072

Molekulargewicht

372.412

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Klasse Diarylheptanoids
      • Subclass Linear diarylheptanoids

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Klasse: Diarylheptanoids
• Subclass: Linear diarylheptanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Curcuminoids
• Alternative Parents: Gingerdiones Phenoxy compounds Methoxybenzenes Anisoles Beta-diketones Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Ketones Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Curcumin - Gingerdione - Methoxyphenol - Anisole - Phenoxy compound - Phenol ether - Methoxybenzene - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - 1,3-diketone - Benzenoid - 1,3-dicarbonyl compound - Monocyclic benzene moiety - Ketone - Ether - Organooxygen compound - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Aromatic homomonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as curcuminoids. These are aromatic compounds containing a curcumin moiety, which is composed of two aryl buten-2-one (feruloyl) chromophores joined by a methylene group.
• External Descriptors: polyphenol - beta-diketone - diarylheptanoid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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OR51E2 Tchem Olfactory receptor 51E2 (2 Activities)

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ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

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DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 (978 Activities)

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ALOX12 Tchem Arachidonate 12-lipoxygenase (3262 Activities)

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STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)

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ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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TERT Tchem Telomerase reverse transcriptase (2428 Activities)

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HEK293 (82097 Activities)

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LNCaP (8286 Activities)

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PBMC (10003 Activities)

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NFKB2 Tchem Nuclear factor NF-kappa-B complex (2307 Activities)

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PTGES Prostaglandin E synthase (10 Activities)

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Abcc1 Multidrug resistance-associated protein 1 (42 Activities)

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pol Human immunodeficiency virus type 1 integrase (9041 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Leishmania major (2877 Activities)

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Leishmania mexicana (936 Activities)

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Plasma (328 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in methanol, chloroform, and DMSO.
• Empfindlichkeit: Light sensitive
• Molekulargewicht: 372.400 g/mol
• XLogP3: 2.800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 372.157 Da
• Monoisotopic Mass: 372.157 Da
• Topological Polar Surface Area: 93.100 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 437.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1