Thromboxane B2 (TXB2) - Moligand™, ≥99% , CAS No.54397-85-2

CAS: 54397-85-2 Cat. No.: T134488 Summenformel: C₂₀H₃₄O₆ Molekulargewicht: 370.48 EG-Nummer: 637-284-6 PubChem CID: 5283137

GRADE & PURITY Moligand™, ≥99%

Synonyms

TXB2 | 5-Heptenoic acid, 7-[(2R,3S,4S)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-, (5Z)-rel- | Q3009646 | TXB2 | SR-01000946531 | HY-113331 | (5Z,13E,15S)-9alpha,11,15-trihydroxythromboxa-5,13-dien-1-oic acid | NCGC0016130

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

TXB2 (Thromboxane B2) is a stable metabolite of thromboxane A2 in platelets which may be released during anaphylaxis. Reportedly possesses chemotactic properties. Often used to measure arachidonic acid metabolism. It is a prostaglandin derivative that is released during anaphylaxis, which induces arterial contraction and platelet aggregation by stimulating TP-α receptors.
A stable metabolite of thromboxane B2.

Specifications

Synonyme

TXB2 | 5-Heptenoic acid, 7-[(2R,3S,4S)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-, (5Z)-rel- | Q3009646 | TXB2 | SR-01000946531 | HY-113331 | (5Z,13E,15S)-9alpha,11,15-trihydroxythromboxa-5,13-dien-1-oic acid | NCGC0016130

Spezifikationen & Reinheit

Moligand™, ≥99%

Biochemische und physiologische Mechanismen

Prostaglandin derivative that is released during anaphylaxis; induces arterial contraction and platelet aggregation. Review of endogenous thromboxane B2 in risk analysis for development of thrombogenic disorders.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Reinheit

≥99%

Namen und Kennungen

• Kanonisches Lächeln: CCCCCC(C=CC1C(C(CC(O1)O)O)CC=CCCCC(=O)O)O
• IUPAC Name: (Z)-7-[(2R,3S,4S)-4,6-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]oxan-3-yl]hept-5-enoic acid
• InChIKey: XNRNNGPBEPRNAR-JQBLCGNGSA-N
• INCHI: 1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1
• Isomere SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@H](CC(O1)O)O)C/C=C\CCCC(=O)O)O
• WGK Deutschland: 3
• PubChem CID: 5283137
• Molekulargewicht: 370.48

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Klasse Fatty Acyls
      • Subclass Eicosanoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Klasse: Fatty Acyls
• Subclass: Eicosanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Thromboxanes
• Alternative Parents: Long-chain fatty acids Hydroxy fatty acids Heterocyclic fatty acids Unsaturated fatty acids Oxanes Secondary alcohols Hemiacetals Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Thromboxane - Long-chain fatty acid - Heterocyclic fatty acid - Hydroxy fatty acid - Fatty acid - Oxane - Unsaturated fatty acid - Hemiacetal - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Oxacycle - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Carbonyl group - Alcohol - Organooxygen compound - Aliphatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as thromboxanes. These are eicosanoids structurally characterized by the presence of a 6-member ether containing ring.
• External Descriptors: Thromboxanes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in ethanol (~100 mg/ml), ethyl acetate, PBS pH7.2 (~100 μg/ml), and methyl acetate (~10 mg/ml). Insoluble in water.
• Molekulargewicht: 370.500 g/mol
• XLogP3: 2.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 12
• Exact Mass: 370.236 Da
• Monoisotopic Mass: 370.236 Da
• Topological Polar Surface Area: 107.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 448.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1