Tinidazole - Moligand™, 10mM in DMSO , DNA inhibitor, CAS No.19387-91-8, DNA inhibitor

CAS: 19387-91-8 Cat. No.: T407955 Summenformel: C₈H₁₃N₃O₄S Molekulargewicht: 247.27 EG-Nummer: 243-014-4 PubChem CID: 5479

QUALITÄT & REINHEIT Moligand™, 10mM in DMSO

Synonyms

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Tinidazole Tinidazole (CP12574) is an anti-parasitic drug.
In vitro

Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Spezifikationen

Synonyme

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Tinidazole (CP12574) is an anti-parasitic drug.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

DNA inhibitor

Namen und Kennungen

Isomere SMILES

CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C

RTECS

NI6255000

PubChem CID

5479

Molekulargewicht

247.27

Reaxy-Rn

618182

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 100 mg/mL (162.21 mM); Water: Insoluble; Ethanol: Insoluble
• Schmelzpunkt (°C): 129 °C