TK216 - 10mM in DMSO , CAS No.1903783-48-1

CAS: 1903783-48-1 Cat. No.: T422332 Summenformel: C₁₉H₁₅Cl₂NO₃ Molekulargewicht: 376.23 PubChem CID: 121268274

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

2H-​Indol-​2-​one,4,​7-​dichloro-​3-​[2-​(4-​cyclopropylphenyl)​-​2-​oxoethyl]​-​1,​3-​dihydro-​3-​hydroxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

TK216 TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.

Targets

ETS

In vitro

TK-216 demonstrates an antitumor activity across several lymphoma cell lines. Synergistic activity is observed when TK-216 is combined with the BCL2 inhibitor venetoclax and with the immunomodulatory drug lenalidomide.

In vivo

TK-216 demonstrates an antitumor activity in vivo. TK-216 interferes with protein interactions of ETS family members SPIB, in activated B-cell–like type diffuse large B-cell lymphomas, and SPI1, in germinal center B-cell–type diffuse large B-cell lymphomas.

Cell Research(from reference)

Cell lines：ABC-DLBCL, GCB-DLBCL, MCL, MZL, CLL, primary mediastinal large B-cell lymphoma, cutaneous T-cell lymphoma, PTCL-NOS, ALCL, canine DLBCL 

Concentrations：50 nM 

Incubation Time：24 h, 48 h, 72 h 

Spezifikationen

Synonyme

2H-​Indol-​2-​one,4,​7-​dichloro-​3-​[2-​(4-​cyclopropylphenyl)​-​2-​oxoethyl]​-​1,​3-​dihydro-​3-​hydroxy-

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Produkteigenschaften

ALogP

3.785

HBD-Zahl

1

Rotationsfähige Bindung

4

Namen und Kennungen

Pubchem Sid

528767406

Kanonisches Lächeln

C1CC1C2=CC=C(C=C2)C(=O)CC3(C4=C(C=CC(=C4NC3=O)Cl)Cl)O

IUPAC Name

4,7-dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one

InChIKey

ZWHNLSHDLKIXOG-UHFFFAOYSA-N

INCHI

1S/C19H15Cl2NO3/c20-13-7-8-14(21)17-16(13)19(25,18(24)22-17)9-15(23)12-5-3-11(4-6-12)10-1-2-10/h3-8,10,25H,1-2,9H2,(H,22,24)

PubChem CID

121268274

Molekulargewicht

376.23

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Klasse Organooxygen compounds
      • Subclass Carbonyl compounds
        • Ebene5 Ketones
          • Ebene6 Aryl ketones
            • Ebene7 Phenylketones
              • Ebene8 Alkyl-phenylketones

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Klasse: Organooxygen compounds
• Subclass: Carbonyl compounds
• Intermediate Tree Nodes: Ketones - Aryl ketones - Phenylketones
• Direct Parent: Alkyl-phenylketones
• Alternative Parents: 3-alkylindoles Benzoyl derivatives Aryl alkyl ketones Beta-hydroxy ketones Aryl chlorides Tertiary alcohols Cyclic carboximidic acids Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alkyl-phenylketone - 3-alkylindole - Indole or derivatives - Aryl alkyl ketone - Benzoyl - Benzenoid - Beta-hydroxy ketone - Monocyclic benzene moiety - Aryl halide - Aryl chloride - Cyclic carboximidic acid - Tertiary alcohol - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Organochloride - Organohalogen compound - Alcohol - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• DMSO (mg/ml) Maximale Löslichkeit: 75
• DMSO (mM) Maximale Löslichkeit: 199.346144645563
• Wasser (mg/ml) Maximale Löslichkeit: ＜1
• Molekulargewicht: 376.200 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 375.043 Da
• Monoisotopic Mass: 375.043 Da
• Topological Polar Surface Area: 66.400 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 559.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1