TP0427736 hydrochloride - ≥98% , CAS No.2459963-17-6

CAS: 2459963-17-6 Cat. No.: T646401 Summenformel: C₁₄H₁₁ClN₄S₂ Molekulargewicht: 334.9 PubChem CID: 137277519

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC 50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC 50 =836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC 50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA).

Form:Solid

Specifications

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC 50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC 50 =836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cel

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥98%

Namen und Kennungen

Kanonisches Lächeln

CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4.Cl

IUPAC Name

6-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole;hydrochloride

InChIKey

DBKPLYNIVZJPCU-UHFFFAOYSA-N

INCHI

1S/C14H10N4S2.ClH/c1-8-5-19-14(18-8)13-12(15-6-16-13)9-2-3-10-11(4-9)20-7-17-10;/h2-7H,1H3,(H,15,16);1H

PubChem CID

137277519

Molekulargewicht

334.9

Chemische und physikalische Eigenschaften

• Molekulargewicht: 334.900 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 334.011 Da
• Monoisotopic Mass: 334.011 Da
• Topological Polar Surface Area: 111.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 356.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2459963-17-6, the molecular formula is C14H11ClN4S2, and the molecular weight is 334.9 g/mol. InChIKey DBKPLYNIVZJPCU-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.