Tylosin solution - BioReagent, for cell culture, 0.1 μm filtered, 8 mg/mL in 0.9% NaCl , CAS No.74610-55-2

CAS: 74610-55-2 Cat. No.: T433510 Summenformel: 2(C₄₆H₇₇NO₁₇).C₄H₆O₆ EG-Nummer: 616-119-1

GRADE & PURITY BioReagent, for Cell culture, 0.1 μm filtered, 8 mg/mL in 0.9% NaCl

Synonyms

s3162 | TYLOSIN TARTRATE [USP MONOGRAPH] | Tylosin, (2R,3R)-2,3-dihydroxybutanedioate (1:1) | Tylosin tartrate (USP) | Tylosin (tartrate) | NSC 758961 | Tylan injectable | EINECS 215-781-5 | DTXSID3045938 | Tylosin tartrate, potency: >=800 units/mg tylosi

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Übersicht

General Description

Chemical structure: macrolide Tylosin is a macrolide antibiotic, which comprises of a 16-member lactone ring. This solution is recommended for use at 1 mL/L.

Application

Tylosin solution has been used as an antimicrobial agent in antibiotic susceptibility minimal inhibitory concentration(MIC) of E. coli and S. aureus isolates. It has also been used as a component of Dulbecco′s modified Eagle′s (DMEM) medium for self-inactivating lentivirus production and skin fibroblast cultivation.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Specifications

Synonyme

s3162 | TYLOSIN TARTRATE [USP MONOGRAPH] | Tylosin, (2R,3R)-2,3-dihydroxybutanedioate (1:1) | Tylosin tartrate (USP) | Tylosin (tartrate) | NSC 758961 | Tylan injectable | EINECS 215-781-5 | DTXSID3045938 | Tylosin tartrate, potency: >=800 units/mg tylosi

Spezifikationen & Reinheit

BioReagent, for cell culture, 0.1 μm filtered, 8 mg/mL in 0.9% NaCl

Biochemische und physiologische Mechanismen

Tylosin inhibits bacterial protein synthesis by binding to the large subunit 50S. It is effective against Gram-positive bacteria and mycoplasma and is used in veterinary medicine. It has been used to study implant site abscess prevention in cattle and M

Storage

Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

BioReagent, für die Zellkultur

Aktionsart

INHIBITOR

Namen und Kennungen

• Pubchem Sid: 528772914
• Kanonisches Lächeln: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC
• IUPAC Name: (2R,3R)-2,3-dihydroxybutanedioic acid;2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
• InChIKey: ICVKYYINQHWDLM-KBEWXLTPSA-N
• INCHI: 1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
• Isomere SMILES: CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Klasse Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Ebene5 Aminosaccharides
          • Ebene6 Aminoglycosides

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Klasse: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Aminosaccharides
• Direct Parent: Aminoglycosides
• Alternative Parents: Macrolides and analogues Disaccharides O-glycosyl compounds Short-chain hydroxy acids and derivatives Beta hydroxy acids and derivatives Sugar acids and derivatives Oxanes Alpha hydroxy acids and derivatives Fatty acids and conjugates Dicarboxylic acids and derivatives Alpha-hydrogen aldehydes Tertiary alcohols Secondary alcohols 1,2-aminoalcohols Cyclic ketones Trialkylamines Lactones Amino acids and derivatives Carboxylic acid esters Oxacyclic compounds Acetals Dialkyl ethers Carboxylic acids Hydrocarbon derivatives Organopnictogen compounds Organic oxides
• Molecular Framework: Not available
• Substituents: Aminoglycoside core - Macrolide - Disaccharide - Glycosyl compound - O-glycosyl compound - Beta-hydroxy acid - Short-chain hydroxy acid - Sugar acid - Alpha-hydroxy acid - Dicarboxylic acid or derivatives - Hydroxy acid - Fatty acid - Oxane - Tertiary alcohol - Alpha-hydrogen aldehyde - Secondary alcohol - Tertiary aliphatic amine - Tertiary amine - Cyclic ketone - Lactone - Ketone - 1,2-aminoalcohol - Amino acid or derivatives - Carboxylic acid ester - Oxacycle - Organoheterocyclic compound - Ether - Carboxylic acid derivative - Carboxylic acid - Dialkyl ether - Acetal - Organic nitrogen compound - Aldehyde - Amine - Organopnictogen compound - Carbonyl group - Organic oxide - Organonitrogen compound - Alcohol - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Molekulargewicht: 1066.200 g/mol
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 24
• Rotatable Bond Count: 16
• Exact Mass: 1065.54 Da
• Monoisotopic Mass: 1065.54 Da
• Topological Polar Surface Area: 354.000 Ų
• Heavy Atom Count: 74
• Formal Charge: 0
• Complexity: 1700.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 23
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 2

XLogP3

Referenzen

1. Bing Wang, Qingtong Cao, Ming Cheng, Guomin Li, Jian Zhang, Hong Jiang.  (2023)  Photocatalytic degradation of antibiotics in water by pollution-free photocatalytic films with a three-dimensional layered structure and the reaction mechanism study.  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2023.103550]

2. Zhiyan Huang, Tenglu Wang, Minxian Shen, Zhujian Huang, Yunxiao Chong, Lihua Cui.  (2019)  Coagulation treatment of swine wastewater by the method of in-situ forming layered double hydroxides and sludge recycling for preparation of biochar composite catalyst.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2019.03.136]

3. Chan-Yuan YAO, Jin-Yi YANG, Zhen-Lin XU, Hong WANG, Hong-Tao LEI, Yuan-Ming SUN, Yuan-Xin TIAN, Yu-Dong SHEN.  (2018)  Indirect Competitive Enzyme-Linked Immunosorbent Assay for Detection of Tylosin in Milk and Water Samples.  CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,      [PMID:] [10.1016/S1872-2040(18)61106-5]

4. Yuehong Song, Shanshan Song, Liqiang Liu, Hua Kuang, Lingling Guo, Chuanlai Xu.  (2015)  Simultaneous detection of tylosin and tilmicosin in honey using a novel immunoassay and immunochromatographic strip based on an innovative hapten.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2015.1089843]

5. Liubing Fan, Shiqiang Hao, Shihui He, Xusheng Zhang, Mingyang Li, Christopher Wolverton, Jing Zhao, Quanlin Liu.  (2023)  Luminescent hybrid halides with various centering metal cations (Zn, Cd and Pb) and diverse structures.  DALTON TRANSACTIONS,  52  (16): (5119-5126).  [PMID:36961101] [10.1039/D2DT04067K]

6. Tian-Yu Qiu, Ying-Nan Zhao, Wen-Si Tang, Hua-Qiao Tan, Hui-Ying Sun, Zhen-Hui Kang, Xia Zhao, Yang-Guang Li.  (2022)  Smart Covalent Organic Framework with Proton-Initiated Switchable Photocatalytic Aerobic Oxidation.  ACS Catalysis,      [PMID:] [10.1021/acscatal.2c03796]

7. Wang-Xi Fan, Zefang Li, Zhou Yang, Jun-Fei Ou, Meng Xiang, Zhong-Li Qin.  (2022)  Improving the curing and flame retardancy of epoxy resin composites by multifunctional Si-containing cyclophosphazene derivatives.  RSC Advances,  12  (22): (13756-13764).  [PMID:35530380] [10.1039/D1RA08843B]

8. Xin Chen, Duanxiu Li, Yanwen Duan, Yong Huang.  (2022)  Characterization of co-amorphous sinomenine-tranilast systems with strong intermolecular interactions and sustained release profiles.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2022.103296]

9. Haiyun Li, Yizhi Qiu, Tuo Yao, Yachun Ma, Huirong Zhang, Xiaolei Yang, Changning Li.  (2019)  Evaluation of seven chemical pesticides by mixed microbial culture (PCS-1): Degradation ability, microbial community, and Medicago sativa phytotoxicity.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:31843407] [10.1016/j.jhazmat.2019.121834]

10. Xiangqian Li, Jiapei Gu, Zhan Zhou, Wanqiang Liu, Jinwei Gao, Qianming Wang.  (2019)  Precise control for the aggregation and deaggregation with the aid of a tetraphenylethylene derivative: Luminescence modulation and sensing performance.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2019.107844]

11. Tianlu Xu, Chunling Zhang, Peihong Li, Xueyan Dai, Lijie Qu, Yanlong Sui, Jinjia Gu, Yanli Dou.  (2018)  Preparation of dual-functionalized graphene oxide for the improvement of the thermal stability and flame-retardant properties of polysiloxane foam.  NEW JOURNAL OF CHEMISTRY,  42  (16): (13873-13883).  [PMID:] [10.1039/C8NJ02361A]

12. Dong Zhou, Ruliang Liu, Yan-Bing He, Fengyun Li, Ming Liu, Baohua Li, Quan-Hong Yang, Qiang Cai, Feiyu Kang.  (2016)  SiO2 Hollow Nanosphere-Based Composite Solid Electrolyte for Lithium Metal Batteries to Suppress Lithium Dendrite Growth and Enhance Cycle Life.  Advanced Energy Materials,  6  (7): (1502214).  [PMID:] [10.1002/aenm.201502214]

13. Yuzhen Xu, Liyan Qiu.  (2015)  Nonspecifically enhanced therapeutic effects of vincristine on multidrug-resistant cancers when coencapsulated with quinine in liposomes.  International Journal of Nanomedicine,      [PMID:26170660] [10.2147/IJN.S84555]

14. Yvhao Xie, Xinxin Li, Qingshi Meng, Jinjun Li, Xin Wang, Liying Zhu, Weiwei Wang, Xiaoqiong Li.  (2024)  Interplay between gut microbiota and tryptophan metabolism in type 2 diabetic mice treated with metformin.  Microbiology Spectrum,      [PMID:39162538] [10.1128/spectrum.00291-24]