U-73343 - ≥98% , CAS No.142878-12-4

CAS: 142878-12-4 Cat. No.: U276451 Summenformel: C₂₉H₄₂N₂O₃ Molekulargewicht: 466.7 EG-Nummer: 634-320-2 PubChem CID: 114825

GRADE & PURITY ≥98%

Synonyms

2,5-PYRROLIDINEDIONE, 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)- | 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-2,5-PYRROLIDINEDIONE | DTXSID2036740 | S2C4J8704C | SCHEMBL2678917 | 1-(6-((17BETA-3-METHOXYES

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Übersicht

Product description：

U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 µM for PLC。

Application：

U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells.

U-73343 has been used in measuring the fluorescence of intracellular Ca2+.

Specifications

Synonyme

2,5-PYRROLIDINEDIONE, 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)- | 1-(6-(((17.BETA.)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-2,5-PYRROLIDINEDIONE | DTXSID2036740 | S2C4J8704C | SCHEMBL2678917 | 1-(6-((17BETA-3-METHOXYES

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Negative control for phospholipase C (PLC) inhibitor U73122 .

Storage

Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 504756725
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756725
• Kanonisches Lächeln: CC12CCC3C(C1CCC2NCCCCCCN4C(=O)CCC4=O)CCC5=C3C=CC(=C5)OC
• IUPAC Name: 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrolidine-2,5-dione
• InChIKey: CJHWFIUASFBCKN-ZRJUGLEFSA-N
• INCHI: 1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
• Isomere SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)CCC4=O)CCC5=C3C=CC(=C5)OC
• PubChem CID: 114825
• Molekulargewicht: 466.7

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Klasse Steroids and steroid derivatives
      • Subclass Azasteroids and derivatives

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Klasse: Steroids and steroid derivatives
• Subclass: Azasteroids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Azasteroids and derivatives
• Alternative Parents: Estrane steroids Phenanthrenes and derivatives Tetralins Anisoles Alkyl aryl ethers Aralkylamines Pyrrolidine-2-ones N-substituted carboxylic acid imides N-alkylpyrrolidines Dicarboximides Amino acids and derivatives Lactams Dialkylamines Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 20-azasteroid - Estrane-skeleton - Azasteroid - Phenanthrene - Tetralin - Anisole - Alkyl aryl ether - Aralkylamine - Carboxylic acid imide, n-substituted - Pyrrolidone - 2-pyrrolidone - N-alkylpyrrolidine - Benzenoid - Carboxylic acid imide - Dicarboximide - Pyrrolidine - Amino acid or derivatives - Lactam - Carboxylic acid derivative - Azacycle - Secondary aliphatic amine - Organoheterocyclic compound - Secondary amine - Ether - Amine - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxygen compound - Organopnictogen compound - Organic oxide - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as azasteroids and derivatives. These are steroid derivatives in which one carbon atom in the steroidal skeleton has been substituted with a nitrogen atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

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MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

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SH-SY5Y (11521 Activities)

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HEK293 (82097 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

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Zugehörige Ziele (nicht menschlich)

Saccharomyces cerevisiae (19171 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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hsp60 Chaperonin GroEL (Thermosome, HSP60 family) (16 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO (Slightly, Heated, Sonicated), Ethanol (Slightly, Heated), Methanol (Slightly)
• Schmelzpunkt (°C): 139- 141° C
• Molekulargewicht: 466.700 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 466.32 Da
• Monoisotopic Mass: 466.32 Da
• Topological Polar Surface Area: 58.600 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 725.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 142878-12-4, the molecular formula is C29H42N2O3, and the molecular weight is 466.7 g/mol. InChIKey CJHWFIUASFBCKN-ZRJUGLEFSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.