UAMC-3203 - 10mM in DMSO , CAS No.2271358-64-4

CAS: 2271358-64-4 Cat. No.: U408498 Summenformel: C₂₅H₃₇N₅O₂S Molekulargewicht: 471.66 PubChem CID: 137701965

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

Benzenesulfonamide, 4-​(cyclohexylamino)​-​3-​[(phenylmethyl)​amino]​-​N-​[2-​(1-​piperazinyl)​ethyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
In vitro

UAMC-3203 has an impressive t1/2 when incubated with both human and rat microsomes (t1/2 = 20.5 h and t1/2 = 16.5 h respectively) but is found to be relatively less stable when incubated with murine microsomes (t1/2 = 3.46 h).

In vivo

UAMC-3203 significantly lowers the plasma levels of lactate dehydrogenase (LDH) in mice. It is rapidly removed from the bloodstream and redistributed into various tissues, as can be expected for lipophilic basic compounds. Significant concentrations of UAMC-3203 are found in all analyzed tissues (liver, kidney, and lungs).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Spezifikationen

Synonyme

Benzenesulfonamide, 4-​(cyclohexylamino)​-​3-​[(phenylmethyl)​amino]​-​N-​[2-​(1-​piperazinyl)​ethyl]​-

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Produkteigenschaften

ALogP

3.36

HBD-Zahl

4

Rotationsfähige Bindung

10

Namen und Kennungen

Isomere SMILES

C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)NCCN3CCNCC3)NCC4=CC=CC=C4

PubChem CID

137701965

Molekulargewicht

471.66

Chemische und physikalische Eigenschaften

• DMSO (mg/ml) Maximale Löslichkeit: 94
• DMSO (mM) Maximale Löslichkeit: 199.296103125133
• Wasser (mg/ml) Maximale Löslichkeit: ＜1