UPF 1069 - 10mM in DMSO , CAS No.1048371-03-4

CAS: 1048371-03-4 Cat. No.: U408511 Summenformel: C₁₇H₁₃NO₃ Molekulargewicht: 279.29 EG-Nummer: 687-145-9 PubChem CID: 25015515

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

UPF 1069 is a selectivePARP2inhibitor withIC50of 0.3 μM. It is ~27-fold selective against PARP1.
In vitro

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM.

In vivo

In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Spezifikationen

Synonyme

1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Isomere SMILES

C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O

PubChem CID

25015515

Molekulargewicht

279.29

Zugehörige Ziele (menschlich)

PARP1 Tclin Poly [ADP-ribose] polymerase 1 (2 Activities)

Discover Target: PARP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP2 Tclin Poly [ADP-ribose] polymerase 2 (1 Activities)

Discover Target: PARP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 81 mg/mL (199.08 mM); Water: 81 mg/mL (199.08 mM); Ethanol: 81 mg/mL (199.08 mM)
• Brechungsindex: 1.62
• Siedepunkt (°C): ~570.3 °C at 760 mmHg
• Schmelzpunkt (°C): 166-168°C