Urofollitropin - Moligand™, ＞100 IU/mg , Agonist of FSH receptor, CAS No.97048-13-0, Agonist of FSH receptor

CAS: 97048-13-0 Cat. No.: U139597 Summenformel: C₄₂H₆₅N₁₁O₁₂S₂ Molekulargewicht: 980.16 EG-Nummer: 685-388-5 PubChem CID: 62819

GRADE & PURITY Moligand™, ＞100 IU/mg

Synonyms

Urofollitropin|97048-13-0|146479-72-3|Follicle-stimulating hormone|1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-ami

Storage

Lagerung bei 2-8°C

Shipped In

Nasses Eis

Übersicht

Urofollitropin ist ein Trockenpräparat mit menopausalem Gonadotropin, das aus dem Urin von Frauen nach der Menopause gewonnen wird. Es hat eine follikelstimulierende Aktivität und keine oder praktisch keine luteinisierende Aktivität. Die Potenz beträgt mindestens 90 Internationale Einheiten des follikelstimulierenden Hormons (hFSH) pro Milligramm. Das Verhältnis von Einheiten des luteinisierenden Hormons (interstitielles zellstimulierendes Hormon) [hLH(ICSH)] zu Einheiten des follikelstimulierenden Hormons beträgt nicht mehr als 1/60.

Specifications

Synonyme

Urofollitropin | 97048-13-0 | 146479-72-3 | Follicle-stimulating hormone | 1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-ami

Spezifikationen & Reinheit

Moligand™, ＞100 IU/mg

Storage

Lagerung bei 2-8°C

Verschickt in

Nasses Eis

Note

Moligand™

Aktionsart

AGONIST

Mechanismus der Wirkung

Agonist of FSH receptor

Namen und Kennungen

Pubchem Sid

528771511

Kanonisches Lächeln

CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C(C)O

IUPAC Name

1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

InChIKey

ZDRRIRUAESZNIH-UHFFFAOYSA-N

INCHI

1S/C42H65N11O12S2/c1-6-21(4)33-40(63)52-34(22(5)54)41(64)49-28(16-31(44)56)37(60)50-29(19-67-66-18-25(43)35(58)47-27(38(61)51-33)15-23-9-11-24(55)12-10-23)42(65)53-13-7-8-30(53)39(62)48-26(14-20(2)3)36(59)46-17-32(45)57/h9-12,20-22,25-30,33-34,54-55H,6-8,13-19,43H2,1-5H3,(H2,44,56)(H2,45,57)(H,46,59)(H,47,58)(H,48,62)(H,49,64)(H,50,60)(H,51,61)(H,52,63)

Isomere SMILES

CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C(C)O

Alternative CAS-Nummer

146479-72-3,97048-13-0

PubChem CID

62819

MeSH-Eintrag

Bravelle;Fertinex;Follicle Stimulating Hormone, Human Urine;Follicle-Stimulating Hormone, Human Urine;Follitrin;High Purity, Metrodin;Human FSH, Urinary;Metrodin;Metrodin High Purity;Metrodin HP;Neo Fertinorm;Urinary Human FSH;Urofollitropin

Molekulargewicht

980.16

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Klasse Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Ebene5 Peptides
          • Ebene6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Klasse: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Cyclic peptides Leucine and derivatives Proline and derivatives Macrolactams N-acyl-alpha amino acids and derivatives Alpha amino acid amides Pyrrolidinecarboxamides N-acylpyrrolidines 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives N-acyl amines Tertiary carboxylic acid amides Secondary carboxylic acid amides Primary carboxylic acid amides Lactams Secondary alcohols Organic disulfides Azacyclic compounds Monoalkylamines Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-oligopeptide - Cyclic alpha peptide - Leucine or derivatives - Macrolactam - Proline or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Fatty acyl - Benzenoid - Monocyclic benzene moiety - N-acyl-amine - Fatty amide - Pyrrolidine - Tertiary carboxylic acid amide - Secondary carboxylic acid amide - Secondary alcohol - Primary carboxylic acid amide - Amino acid or derivatives - Organic disulfide - Carboxamide group - Lactam - Organoheterocyclic compound - Azacycle - Primary amine - Organic oxide - Primary aliphatic amine - Organopnictogen compound - Hydrocarbon derivative - Carbonyl group - Organonitrogen compound - Organooxygen compound - Amine - Organic oxygen compound - Alcohol - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

FSHR Tclin Follicle-stimulating hormone receptor (0 Activities)

Discover Target: FSHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Light Sensitive
• Molekulargewicht: 980.200 g/mol
• XLogP3: -1.500
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 15
• Exact Mass: 979.426 Da
• Monoisotopic Mass: 979.426 Da
• Topological Polar Surface Area: 427.000 Ų
• Heavy Atom Count: 67
• Formal Charge: 0
• Complexity: 1790.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 10
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1