Vecuronium Bromide - 10mM in DMSO , CAS No.50700-72-6

CAS: 50700-72-6 Cat. No.: V408906 Summenformel: C₃₄H₅₇N₂O₄.Br Molekulargewicht: 637.73 Beilstein Registry Number: 4837308 EG-Nummer: 256-723-9 PubChem CID: 39764

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

ORG NC45 | Piperidinium, 1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.
In vitro

Vecuronium inhibits both forms of the muscle-type acetylcholine receptor with IC50 of 1-2 mM. Vecuronium combined with methylprednisolone shows additive effects on both receptor forms, which is best described by a two-site model, with each site independent. Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.

In vivo

Vecuronium (a monoquaternary ammonium compound) has a higher biliary clearance than pancuronium (a bisquaternary ammonium compound) in the rats.
Cell Data

cell lines：A549, H157, H460, H446, HCT116, HT29, SW480, DLD1, Caco2, LNCap, DU145, MDA468, MDA231, HEK293, and PC3-MM2

Concentrations：

Incubation Time：

Powder Purity:≥99%

Spezifikationen

Synonyme

ORG NC45 | Piperidinium, 1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (1:1)

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Isomere SMILES

CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1N4CCCCC4)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]

WGK Deutschland

3

RTECS

TN4875000

PubChem CID

39764

Molekulargewicht

637.73

Beilstein

4837308

Reaxy-Rn

4106207

Chemische und physikalische Eigenschaften

• Spezifische Drehung [α]: 32° (C=1,0.05mol/L HCl)
• Schmelzpunkt (°C): 235 °C(dec.)