Verteporfin - Moligand™, ≥97% , CAS No.129497-78-5

CAS: 129497-78-5 Cat. No.: V129759 Molecular Weight: 718.79 EC Number: 893-418-5

GRADE & PURITY Moligand™, ≥97%

Synonyms

Visudyne | BPD-MA | CL 318952

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis[1]. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation.

Specifications

Synonyms

Visudyne | BPD-MA | CL 318952

Specifications & Purity

Moligand™, ≥97%

Biochemical and Physiological Mechanisms

Vitepofin is a photosensitizer for photodynamic therapy, which can be used to eliminate abnormal blood vessels in eyes related to macular degeneration and other diseases. Vitipofen can accumulate in abnormal blood vessels. When stimulated by non-thermal r

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488195426
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488195426
• Isomeric SMILES: CC1=C(C2=CC3=NC(=CC4=C(C(=C(N4)C=C5[C@@]6([C@@H](C(=CC=C6C(=N5)C=C1N2)C(=O)OC)C(=O)OC)C)C)CCC(=O)OC)C(=C3C)CCC(=O)O)C=C
• WGK Germany: 3
• Molecular Weight: 718.79
• Reaxy-Rn: 14615024
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14615024&ln=

Chemical and Physical Properties

• Solubility: DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• Sensitivity: Light sensitive
• Molecular Weight: 718.800 g/mol
• XLogP3: 4.900
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 12
• Exact Mass: 718.3 Da
• Monoisotopic Mass: 718.3 Da
• Topological Polar Surface Area: 174.000 Ų
• Heavy Atom Count: 53
• Formal Charge: 0
• Complexity: 1500.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Peng Wang, Zhangwen Peng, Liu Yu, Yiling Liu, Hanwen Wang, Ziheng Zhou, Hengdeng Liu, Sheng Hong, Yichu Nie, Yang Deng, Yang Liu, Julin Xie.  (2023)  Verteporfin-Loaded Bioadhesive Nanoparticles for the Prevention of Hypertrophic Scar.  Small Methods,      [PMID:38084464] [10.1002/smtd.202301295]

2. Ze Li, Jinjian Huang, Yungang Jiang, Ye Liu, Guiwen Qu, Kang Chen, Yun Zhao, Peige Wang, Xiuwen Wu, Jianan Ren.  (2022)  Novel Temperature-Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK-Mediated Mechanosensitivity.  Advanced Healthcare Materials,  11  (23): (2201878).  [PMID:36121733] [10.1002/adhm.202201878]

3. Liuyun Gong, Yujie Zhang, Jing Zhao, Yilei Zhang, Kangsheng Tu, Lianying Jiao, Qiuran Xu, Mingzhen Zhang, Suxia Han.  (2022)  All-In-One Biomimetic Nanoplatform Based on Hollow Polydopamine Nanoparticles for Synergistically Enhanced Radiotherapy of Colon Cancer.  Small,  18  (14): (2107656).  [PMID:35150039] [10.1002/smll.202107656]

4. Gao Feng, Shao Tianyi, Yu Yunpeng, Xiong Yujie, Yang Lihua.  (2021)  Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action.  Nature Communications,  12  (1): (1-18).  [PMID:33531505] [10.1038/s41467-021-20965-3]

5. Liu Tao, Chai Shuang, Li Mingyang, Chen Xu, Xie Yutao, Zhao Zehui, Xie Jingjing, Yu Yunpeng, Gao Feng, Zhu Feng, Yang Lihua.  (2024)  A nanoparticle-based sonodynamic therapy reduces Helicobacter pylori infection in mouse without disrupting gut microbiota.  Nature Communications,  15  (1): (1-19).  [PMID:38286999] [10.1038/s41467-024-45156-8]

6. Gao Dandan, Zou Bin, Zhu Kunyuan, Bi Shijun, Zhang Wenxu, Yang Xinyu, Lai Jieyu, Liang Guobiao, Pan Pengyu.  (2024)  Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage.  Journal of Neuroinflammation,  21  (1): (1-17).  [PMID:39428510] [10.1186/s12974-024-03252-y]

7. Ze Li, Jiayang Li, Kang Chen, Guiwen Qu, Shuanghong Yang, Sicheng Li, Ye Liu, Yitian Teng, Rui Ma, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu.  (2025)  Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP-Mediated Mechanosensitization of Intestinal Epithelial Cells.  Advanced Science,      [PMID:40788236] [10.1002/advs.202510717]

8. Shushu Jiang, Shichen Bu, Xiang Kang, Yin Dong, Long Chen, Lin Yuan, Menghao Shi, Meng Du, Minglu Liang, Kai Huang, Liu Yang.  (2025)  Tspan9 Exacerbates Cardiac Hypertrophy by Impairing Cardiac Autophagy.  FASEB JOURNAL,  39  (10): (e70670).  [PMID:40406987] [10.1096/fj.202500150R]

9. Yichen Cai, Yanxin Shao, Hui Yuan, Lina Feng, Jing Wang, Mingfeng Yang, Cong Li, Baoliang Sun, Leilei Mao.  (2025)  Meningeal lymphatic dysfunction drives cognitive impairment after experimental subarachnoid hemorrhage.  Neurotherapeutics,      [PMID:41390288] [10.1016/j.neurot.2025.e00819]

10. Chaorong Wei, Lingke Feng, Jing Liu, Mingxia Xu, Yongsheng Cui, Fengyi Lin, Honglian Yu, Zhanzhan Feng, Hong Zhang, Changyang Gong, Peng Mi.  (2025)  ROS-sensitive nanocarriers for synergistic X-PDT/chemo/immunotherapy of triple-negative breast cancer and metastasis.  Acta Biomaterialia,      [PMID:41412288] [10.1016/j.actbio.2025.12.035]

11. Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia.  (2026)  Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression.  Advanced Science,      [PMID:41538419] [10.1002/advs.202516988]

12. Zhang Jia, Liu Jin, Chen Yuqian, Chen Huan, Meng Yihan, Wang Yan, Qiu Yuanjie, Hu Huizhong, Shi Wenhua, Li Manxiang, Li Man-xiang.  (2026)  Activation of PBK by Gal-3 contributes to pulmonary artery hypertension by promoting PRC1 activation.  RESPIRATORY RESEARCH,      [PMID:41612370] [10.1186/s12931-026-03534-4]