VLX600 - 10mM in DMSO , CAS No.327031-55-0

CAS: 327031-55-0 Cat. No.: V423334 Summenformel: C₁₇H₁₅N₇ Molekulargewicht: 317.35 EG-Nummer: 816-332-1 PubChem CID: 6410104

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

AKOS000354357 | EN300-395210 | MFCD01305422 | Z2694498001 | AS-79800 | 6-methyl-3-{(2E)-2-[1-(pyridin-2-yl)ethylidene]hydrazinyl}-5H-[1,2,4]triazino[5,6-b]indole | SCHEMBL20518451 | Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino(5,6-b)indol-3-y

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

VLX600 VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS) , potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 induces autophagy and mitochondrial inhibition with antitumor activity.

Targets

OXPHOS

In vitro

VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. Mitochondrial inhibition with VLX600 has a direct antitumor effect in vitro while appearing to promote glycolysis through increased AKT signaling and glucose transporter expression. When combined with imatinib, VLX600 prevents imatinib-induced cell cycle escape and reduces p27 expression, leading to increased apoptosis when compared to imatinib alone.

In vivo

VLX600 induces the formation of autolysosomes in vivo. VLX600 displays tumour growth inhibition in vivo. When combined with imatinib, VLX600 reduces p27 expression and prevents imatinib-induced cell cycle escape, likely potentiating the antitumoral effects of Kit inhibition.

Cell Research(from reference)

Cell lines：human GIST-T1 cell line, human HG129 cell line, human GIST-882 cell line, 

Concentrations：2 μM, 6 μM, 12 μM 

Incubation Time：48–72h 

Spezifikationen

Synonyme

AKOS000354357 | EN300-395210 | MFCD01305422 | Z2694498001 | AS-79800 | 6-methyl-3-{(2E)-2-[1-(pyridin-2-yl)ethylidene]hydrazinyl}-5H-[1,2,4]triazino[5,6-b]indole | SCHEMBL20518451 | Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino(5,6-b)indol-3-y

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS), potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 indu

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Produkteigenschaften

ALogP

3.589

HBD-Zahl

2

Rotationsfähige Bindung

3

Namen und Kennungen

Pubchem Sid

528767644

Kanonisches Lächeln

CC1=C2C(=CC=C1)C3=C(N2)N=C(N=N3)NN=C(C)C4=CC=CC=N4

IUPAC Name

6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine

InChIKey

UQOSBPRTQFFUOA-SRZZPIQSSA-N

INCHI

1S/C17H15N7/c1-10-6-5-7-12-14(10)19-16-15(12)22-24-17(20-16)23-21-11(2)13-8-3-4-9-18-13/h3-9H,1-2H3,(H2,19,20,23,24)/b21-11+

Isomere SMILES

CC1=C2C(=CC=C1)C3=C(N2)N=C(N=N3)N/N=C(\C)/C4=CC=CC=N4

PubChem CID

6410104

Molekulargewicht

317.35

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Indoles and derivatives
      • Subclass Indoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Indoles and derivatives
• Subclass: Indoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Indoles
• Alternative Parents: Pyridines and derivatives Benzenoids 1,2,4-triazines Pyrroles Heteroaromatic compounds Hydrazones Azacyclic compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indole - 1,2,4-triazine - Benzenoid - Triazine - Pyridine - Heteroaromatic compound - Pyrrole - Azacycle - Hydrazone - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (nicht menschlich)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• DMSO (mg/ml) Maximale Löslichkeit: 13
• DMSO (mM) Maximale Löslichkeit: 40.9642350716874
• Wasser (mg/ml) Maximale Löslichkeit: ˂1
• Schmelzpunkt (°C): >264°C (dec.)
• Molekulargewicht: 317.300 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 317.139 Da
• Monoisotopic Mass: 317.139 Da
• Topological Polar Surface Area: 91.700 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 468.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1