Vofopitant dihydrochloride - 10mM in DMSO , CAS No.168266-51-1

CAS: 168266-51-1 Cat. No.: V656221 Molecular Weight: 505.36 EC Number: 800-326-0 PubChem CID: 6918330

GRADE & PURITY 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [ 3 H]SP binding to the NK1 receptor with pK i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent

IC50& Target:pKi: 9.5 (NK1, rat), 10.6 (NK1, human)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [ 3 H]SP binding to the NK1 receptor with pK i values of 9.5 and 10.6 in rat and human membranes respectively,

Storage

Argon charged, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: COC1=C(C=C(C=C1)N2C(=NN=N2)C(F)(F)F)CN[C@H]3CCCN[C@H]3C4=CC=CC=C4.Cl.Cl
• Alternate CAS: 168266-51-1
• PubChem CID: 6918330
• MeSH Entry Terms: GR205171A;substance P (6-11), Tyr(6)-D-Phe(7)-D-His(9)-;Tyr(6)-D-Phe(7)-D-His(9)-substance P (6-11)
• Molecular Weight: 505.36

Associated Targets(Human)

TACR1 Tclin Substance-P receptor (2 Activities)

Discover Target: TACR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)