VU6000918 - 10mM in DMSO , CAS No.2101737-32-8

CAS: 2101737-32-8 Cat. No.: V654625 Summenformel: C₁₈H₁₇F₂N₅OS Molekulargewicht: 389.42

QUALITÄT & REINHEIT 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC 50 of 19 nM for hM4

In Vitro

VU6000918 demonstrates statistically significant AHL reversal (18%) from a low oral dose of 0.03 mg/kg and reaches maximal reversal (74%) from a 3 mg/kg dose, with a resulting in vivo plasma EC 50 of 74 nM (0.66 nM unbound) based on terminal concentrations measured in the study animals (1.5 hr post-administration of 17j). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:EC50: 19 nM (hM4)

Spezifikationen

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC 50 of 19 nM for hM4.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Molekulargewicht

389.42