WAY-301385 - 10mM in DMSO , CAS No.17384-23-5

CAS: 17384-23-5 Cat. No.: W422130 Summenformel: C₁₂H₁₁NO₄S₂ Molekulargewicht: 297.35

QUALITÄT & REINHEIT 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

FFAR1 modulator; Pin1-modulating compounds; Pin1-modulating compounds;

Spezifikationen

Spezifikationen & Reinheit

10mM in DMSO

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Molekulargewicht

297.35

Application Protocols

No validated application protocols are provided for this item.

• Item-specific (from Product Data)

  • Tested applications and recommended dilutions: Not specified for this item.

• General small-molecule handling protocol (not product-specific)

  • Stock preparation: Bring vial to room temperature in a desiccator. Briefly spin down. Add anhydrous DMSO to achieve 10–50 mg/mL, mix by gentle vortex and short sonication if needed.
  • Aliquoting: Dispense single-use aliquots (e.g., 10–50 μL) into inert, low-bind tubes. Store at -80°C protected from light and moisture.
  • Working solutions: Dilute stock into assay buffer to the desired concentration, maintaining final DMSO at 0.1–1% v/v. Prepare fresh on the day of use unless stability is established.
  • Quality check: Verify clarity (no precipitate), and, if critical, confirm concentration by UV or LC–MS against a standard curve.
  • Controls: Include solvent-only and, if known, reference-compound controls for benchmarking.

Biological Roles

No target or pathway information is provided for this product.

• Item-specific (from Product Data)

  • Biological/biochemical role: Not specified for this item; refer to primary literature for CAS 17384-23-5.

• General considerations (not product-specific)

  • WAY-series compounds are often reported in literature as small-molecule modulators used to probe receptor signaling, enzyme activity, or transporter function. The exact target class and potency/selectivity profile for WAY-301385 are unknown here.
  • Prior to biological use, confirm identity, purity, and salt form; establish stock stability in the chosen vehicle over the assay time course.
  • Assess potential assay interference (fluorescence, absorbance, redox activity, aggregation) using orthogonal counter-screens.

• Documentation

  • Cite lot number and preparation details (solvent, concentration, final DMSO %) in all experimental records.

• Research Use Note

  • For research use only. Not for human or veterinary use.

Buffer Applications

This product is not a buffer component and does not constitute a buffering system.

• Applicability

  • Not typically used to set or maintain pH. No buffer recipes are associated with this item.

• Practical handling in buffered systems (general)

  • Prepare a concentrated stock (commonly in DMSO), then dilute into the working buffer to the desired final concentration while keeping DMSO ≤0.1–1% v/v.
  • Add stock last to avoid local precipitation; gentle mixing and temperature equilibration (room temperature or 37°C) can help maintain solubility.
  • Filter final working solutions if particulates are observed, using 0.22 μm PVDF/PTFE filters compatible with organic content.

Green Alternatives

Greenness considerations focus on solvent choice and workflow, as the compound itself is fixed.

• Applicability to this item

  • No synthetic use or solvent requirements are specified for this compound; greenness pertains mainly to dissolution, handling, and waste management in your workflow.

• Greener solvent choices (general guidance)

  • Prefer water where feasible by using solubilization aids (cyclodextrins) at low DMSO carryover.
  • Among organics, ethanol and isopropanol are generally considered more benign than DMF or dichloromethane; acetonitrile has favorable properties but is petro-derived.
  • Consider Cyrene or propylene carbonate as greener aprotic alternatives in certain analytics, noting viscosity and assay compatibility tradeoffs.

• Process tips

  • Minimize DMSO percentage in final assays (≤0.5% v/v typical) to reduce solvent burden and cell stress.
  • Use microscale formats to cut solvent use; consolidate waste streams for appropriate disposal.

• Comparison snapshot (general)

  • DMSO: excellent solvency, high boiling, good safety profile but can carry compounds through skin—use PPE.
  • Ethanol: renewable source potential, good miscibility; may perturb biological assays—validate.
  • DMF/DMAC: powerful solvents but reproductive toxins—avoid where not essential.

Pharmaceutical Uses

No pharmacopeial status, dosage-form role, or GMP-related information is provided for this item.

• Item-specific (from Product Data)

  • Pharmaceutical/excipient use: Not specified for this item; supplied strictly for research use only.

• General notes (not product-specific)

  • Research small molecules like WAY-301385 may be used in discovery-stage experiments (e.g., target validation, assay controls) but are not qualified as APIs, clinical candidates, or excipients.
  • If formulation studies are performed in preclinical research, document solvent systems, pH, and excipients rigorously, and confirm stability and compatibility. None of these parameters are specified for this item.

• Compliance reminder

  • Not intended for human or veterinary administration. Not produced under GMP. Consult your institutional guidelines for handling and disposal.

Physical Properties

Physicochemical properties guide handling, solubility screening, and formulation.

• Item-specific (from Product Data)

  • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
  • Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

• Measured specifications for this item

  • Melting point, boiling point, density, refractive index, water/peroxide content, UV cut-off: Not specified for this item; refer to CoA/Spec Sheet.

• Literature/computed (general guidance; not product-specific)

  • For unknown small molecules, initial solubility screening commonly begins with anhydrous DMSO (10–50 mg/mL stock), followed by dilution into assay buffers to a final DMSO content of 0.1–1% v/v.
  • Alternative solvents for stock preparation may include DMF, ethanol, or acetonitrile, guided by polarity and stability. A quick screen at 25–40°C with brief sonication helps determine practical solubility limits.
  • For lipophilic compounds, co-solvent systems (e.g., DMSO→aqueous buffer with 0.01–0.1% Tween-80 or 0.5–2% cyclodextrin) can improve dispersion. Verify no assay interference from excipients.

• Notes on characterization (general)

  • DSC/TGA can establish thermal behavior; VT-NMR or HPLC stability studies help define storage and thaw stability.
  • pKa/logP/logD (if available from literature or prediction tools) are valuable for planning permeability and formulation; for this specific item, values are not provided and should be confirmed from CoA or supplier technical data.

Quality and Grades

Quality expectations for a research-use small molecule reference compound.

• Item-specific (from Product Data)

  • Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

• What grade typically implies (general, not product-specific)

  • Research-use material is commonly characterized by HPLC/UPLC purity and identity confirmation via NMR and MS. Typical library/HTS standards are supplied at ≥95% HPLC purity, but the exact threshold for this item is not specified—verify on the CoA.
  • Where applicable, residual solvent analysis (GC), water content (Karl Fischer), and inorganic content (ICP) may be provided; these values are not specified for this item.
  • If a stabilizer or counter-ion/salt form is present, it will be listed on the CoA. None are specified here.

• Documentation

  • For batch-specific data (purity, identity, salt form, residuals), consult the Certificate of Analysis (CoA) and Specification Sheet. These documents supersede general expectations.

• Fit for purpose

  • For screening/assay use, confirm purity and identity meet your internal thresholds before inclusion in SAR or PK/PD workflows. For analytical reference-standard use, confirm mass balance and known impurities.

• Lot-to-lot consistency

  • Retain aliquots and analytical traces (HPLC/LC–MS) for comparison when changing lots; align with your quality system.

Reaction and Applications

Use cases as a research compound; no specific target or reaction role is provided.

• Item-specific (from Product Data)

  • Manufacturer Applications: Not specified for this item.

• General research applications (not product-specific)

  • Reference tool in biochemical or cell-based assays: Often, WAY-series compounds are used as modulators in target validation, pathway interrogation, or as positive/negative controls in screening cascades. For WAY-301385 specifically, confirm the literature-defined use case via the CAS number and CoA before deployment.
  • Analytical standard: Can serve as a spike-in for LC–MS method development, retention time locking, or cross-lab proficiency testing once identity/purity are verified.
  • SAR enablement: If related analogs are procured, parallel testing under identical conditions enables comparative potency/selectivity assessment.

• Practical considerations

  • Prepare concentrated DMSO stocks and avoid freeze–thaw to maintain integrity (see Storage & Reconstitution).
  • Validate assay tolerance to the chosen vehicle and any solubilizers. Include appropriate solvent controls.
  • If the compound is light- or oxygen-sensitive (not specified), work under subdued light and inert atmosphere until stability is known.

• Documentation

  • Cite batch-specific identifiers (lot, purity, exact mass) in reports/manuscripts. Where applicable, archive raw spectra confirming identity.

Reaction Conditions

No reaction conditions can be recommended for transformations involving this compound without structural information.

• Item-specific (from Product Data)

  • Reaction role (substrate, catalyst, reagent): Not specified for this item.

• General guidance (not product-specific)

  • If employing the compound as a substrate or intermediate, select solvent/base/temperature according to its functional groups and stability profile from the CoA and any primary literature for CAS 17384-23-5.
  • Conduct small-scale scouting experiments to map solubility and stability; monitor by LC–MS or TLC with appropriate visualization.

• Expected yields and timelines

  • Not applicable—insufficient structural detail. Consult literature precedents once the chemotype is confirmed.

Safety and Handling

Handle as a laboratory research chemical with unknown hazards unless otherwise stated.

• Item-specific (from Product Data)

  • Storage Conditions: Store at -80°C.
  • Shipped In: Dry ice packs + Cold packs.
  • GHS Classification, Signal Word, Pictograms, H-Statements: Not specified for this item; refer to SDS.

• General safety guidance (defer to SDS for authoritative details)

  • PPE: Wear lab coat, disposable nitrile gloves, and chemical splash goggles. Handle in a certified chemical fume hood to avoid inhalation of dusts/aerosols.
  • Avoid contact with skin, eyes, and clothing. Prevent ingestion and inhalation. Wash thoroughly after handling.
  • Incompatibilities: Unknown for this item; avoid strong oxidizers and acids/bases until specific compatibility is known. Do not mix with reactive reducing/oxidizing agents without prior assessment.
  • First aid (general): If inhaled—move to fresh air; if on skin—wash with soap and water; if in eyes—rinse cautiously with water for several minutes; if swallowed—rinse mouth. Seek medical advice if symptoms persist. Provide SDS to healthcare personnel.
  • Special risks: Unknown sensitization or environmental hazards—minimize release to the environment and collect waste in labeled containers for disposal per institutional and local regulations.
  • Cryostorage note: Because this item is stored at -80°C, avoid repeated freeze–thaw cycles; thaw only what is required and keep the remainder frozen.

• SDS: Always consult the product-specific SDS for detailed hazard, exposure control, and spill/fire-fighting measures.

Solvent Selection

Choosing a solvent system for stock solutions and assay dilutions when structure-specific solubility is unknown.

• Item-specific (from Product Data)

  • No solvent recommendations are specified for this item; refer to CoA/Spec Sheet.

• General solvent strategy for small-molecule tools (literature/practice)

  • Primary stock solvent: DMSO (anhydrous) at 10–50 mg/mL; brief warming (25–40°C) and sonication can assist dissolution.
  • Secondary options: DMF, acetonitrile, ethanol or isopropanol if DMSO is unsuitable for the assay readout.
  • Aqueous compatibility: Titrate DMSO stocks into buffer to a final 0.1–1% v/v DMSO. Use surfactants (0.01–0.1% polysorbate 80) or cyclodextrins as needed, verifying no assay interference.

• Polarity and miscibility (general properties)

  • DMSO: highly polar aprotic, miscible with water and organics—broad solubilization capability for diverse chemotypes.
  • ACN/EtOH: lower viscosity; may improve pipetting accuracy at high throughput but can impact enzyme/cell assays—validate tolerance.

• Practical tips

  • Filter stocks through 0.22 μm PTFE or PVDF if particulates persist. Avoid cellulose filters with strong organic solvents.
  • Record exact solvent composition in ELN/LIMS; maintain consistent vehicle controls across experiments.
  • If the compound proves unstable in protic solvents, prepare single-use aliquots in dry aprotic solvents under inert atmosphere.

Storage and Reconstitution

Best practices to preserve integrity and ensure consistent performance.

• Item-specific (from Product Data)

  • Storage Conditions: Store at -80°C.
  • Shipped In: Dry ice packs + Cold packs.

• Reconstitution (general guidance; not product-specific)

  • Thaw the container in a desiccated environment to avoid condensation ingress. Open only after reaching room temperature.
  • Prepare a concentrated stock in an appropriate dry solvent (commonly anhydrous DMSO). If insoluble, consider DMF, acetonitrile, or ethanol, verifying assay compatibility.
  • Filter if necessary using a solvent-compatible 0.22 μm membrane (PTFE/PVDF).

• Aliquoting and stability

  • Create multiple single-use aliquots to avoid repeated freeze–thaw cycles. Store aliquots tightly sealed at -80°C, preferably under inert gas if oxygen sensitivity is suspected (not specified).
  • Protect from light and moisture as a precaution unless stability data indicate otherwise.

• Working solution handling

  • Use freshly prepared dilutions; discard remaining working solutions after use unless supported by stability data.

• Specifications not provided for this item

  • Solubility in common solvents, pKa/logP, hygroscopicity, and light sensitivity: Not specified for this item; refer to CoA/Spec Sheet.

• Research Use Note

  • For research use only.

Structure and Identity

Concise overview of the research compound identified by its WAY-code.

• Item-specific (from Product Data)

  • SKU: W422130
  • Product Name: WAY-301385
  • CAS: 17384-23-5
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
  • InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.

• Structural features (general note)

  • Structural class/functional groups, ring systems, and stereochemistry: Not specified for this item; refer to CoA/Spec Sheet.
  • WAY-series identifiers are commonly used for small-molecule research tools; the exact chemotype for WAY-301385 should be verified from the certificate of analysis (CoA) or primary literature tied to CAS 17384-23-5.

• 2D structure (descriptive)

  • Without a provided structure, functional groups and substitution pattern cannot be described. Please consult the product CoA/Spec Sheet for the definitive 2D representation and identifiers (SMILES/InChI).

Synthetic Utility

Synthetic applications cannot be detailed without a known structure.

• Item-specific (from Product Data)

  • Structural class and reactive handles: Not specified for this item; refer to CoA/Spec Sheet.

• General considerations (not product-specific)

  • If derivatization or bioconjugation is intended, first confirm the presence of suitable functional handles (e.g., amines, phenols, carboxyls, halides) from the structural data.
  • For analytical method development, the compound can function as a reference material to calibrate retention and response factors in LC–MS/UV workflows once identity/purity are verified.

• Retrosynthetic planning

  • Without functional group information, named-reaction guidance (e.g., Suzuki, Buchwald–Hartwig, amide coupling) cannot be provided. Please consult the structure tied to CAS 17384-23-5 for route evaluation.

Target Specificity

Target information is not provided for this product.

• Item-specific (from Product Data)

  • Intended biological target(s), mode of action, selectivity: Not specified for this item.

• Guidance

  • If WAY-301385 has a defined target in the literature, confirm activity, selectivity, and off-target profile under your assay conditions before using it as a reference control. Document batch identity and purity to ensure reproducibility.