WF-47-JS03 - ≥99% , CAS No.W658865

CAS: W658865 Cat. No.: W658865 Summenformel: C₃₀H₃₈N₆O₂ Molekulargewicht: 514.66

QUALITÄT & REINHEIT ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

WF-47-JS03 is a potent and selective RET kinase inhibitor with IC 50 s of 1.7 nM and 5.3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively. WF-47-JS03 demonstrates >500-fold selectivity against kina

Appearance:Solid

In Vitro:WF-47-JS03 inhibits Tel-KDR transfected Ba/F3 cells and Ba/F3 wild-type cell lines with IC 50 s of 0.99 and 1.5 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo:WF-47-JS03 significantly inhibits tumor growth in RIE KIF5B-RET xenograft mice and is well tolerated at 1, 3, and 10mg/kg in the 10 day study. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Mod

Biological Activity:WF-47-JS03 is a potent and selective RET kinase inhibitor with IC 50 s of 1.7 nM and 5.3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively. WF-47-JS03 demonstrates >500-fold selectivity against kina

Spezifikationen

Spezifikationen & Reinheit

≥99%

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Namen und Kennungen

Kanonisches Lächeln

NC(N1C(N=C2NC3CC(C)(C)N(C)C(C)(C)C3)=C(C4=CC(OC)=C(OC)C=C4)C=N1)=C2C5=CC=CC=C5

Molekulargewicht

514.66

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 62.5 mg/mL (121.44 mM; Need ultrasonic)