XMU-MP-9 - Moligand™, 10 mM in DMSO , CAS No.2251130-41-1

CAS: 2251130-41-1 Cat. No.: X1498520 Summenformel: C₁₉H₁₃ClFN₃OS Molekulargewicht: 385.84

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Protected from light,Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras . XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras , induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used in cancer research.

Specifications

Spezifikationen & Reinheit

Moligand™, 10 mM in DMSO

Storage

Protected from light,Argon charged,Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Namen und Kennungen

Molekulargewicht

385.84

Application Protocols

No tested application protocols or dilutions are specified in the Product Data for this item.

General workflow suggestions for small-molecule tool compounds (informational)

• Stock preparation: Prepare a concentrated solution in anhydrous DMSO (e.g., 10–50 mM). Vortex and, if needed, briefly sonicate. Filter sterilize if required by the assay and compatible with the solvent.
• Working concentrations: Define via preliminary titration (e.g., 8–12 point dose–response) tailored to your readout. Keep vehicle controls matching the highest DMSO percentage used.
• Assay controls: Include positive/negative pathway controls and at least one orthogonal assay (e.g., reporter assay plus endogenous marker measurement) to confirm on-target effects.
• Stability checks: For multi-hour or multi-day assays, confirm compound stability in plate media by LC or re-readouts at staged time points. Protect from light throughout handling.

Important

• These are general practices derived from common use of small-molecule tools. They are not item-specific instructions. Always adapt to your platform and consult the CoA/SDS.

Biological Roles

Biological/biochemical context (literature information; not item-specific)

• XMU-MP-9 is widely cited in the literature as a small-molecule tool used to interrogate the Hippo signaling pathway. It is commonly described as an inhibitor of MST1/2 kinases, leading to stabilization/activation of downstream YAP/TAZ transcriptional co-activators (literature). Users leverage this to study regulation of cell proliferation, mechanotransduction, and tissue growth signaling in cellular and biochemical models.

Important notes

• The above functional description is provided as general literature context only and does not constitute a specification or endorsement of performance for this particular SKU/lot. Activity can be assay- and context-dependent.
• For quantitative biochemical parameters (e.g., IC50, selectivity panels, cellular target engagement), consult peer-reviewed sources and verify under your laboratory conditions.

Practical guidance

• For pathway readouts, researchers frequently measure YAP/TAZ nuclear localization, TEAD-reporter activity, or expression of YAP/TAZ target genes as orthogonal confirmation of pathway modulation (literature practice).
• When translating between systems (biochemical to cellular), evaluate protein binding, permeability, and stability in the assay medium; confirm exposure via LC-MS/MS if possible.

Compliance

• Research use only. No claims are made regarding therapeutic, diagnostic, or clinical utility.

Buffer Applications

This product is not a buffering agent and is not used to establish or maintain pH in aqueous systems.

Practical note for assay buffers

• If using this compound in biochemical or cell-based assays, choose a buffer system compatible with your biological target (e.g., HEPES, PBS, Tris) and with the organic cosolvent level required for solubility (commonly ≤0.1–0.5% DMSO v/v, depending on assay tolerance).
• Confirm compound solubility upon dilution into buffer by visual inspection and analytical verification (e.g., HPLC).

Green Alternatives

Green chemistry substitution is generally discussed for solvents and bulk reagents. As XMU-MP-9 is a specialized small-molecule research tool, greener alternatives are not typically applicable in the same sense as solvent replacement.

Considerations for greener practice with small-molecule tool compounds

• Minimize mass and waste: Plan experiments to use the smallest feasible quantities and scale.
• Solution management: Prepare concentrated master stocks to reduce solvent volumes and packaging waste; aliquot to avoid repeated freeze–thaw and disposal of degraded material.
• Solvent choice: When possible, select assay vehicles with better environmental profiles (e.g., water-buffer systems with minimal DMSO), consistent with required solubility and biological compatibility.
• Waste handling: Segregate halogenated vs non-halogenated solvent waste; follow institutional guidance to reduce environmental impact.

If you are evaluating different bioactive tool compounds for the same biological question, consider availability, stability, and off-target liability rather than "green" metrics alone, as the primary environmental footprint stems from scale and solvent use in assays rather than the microgram-to-milligram quantities of the tool compound itself.

Pharmaceutical Uses

No pharmaceutical or clinical uses are claimed for this product. It is supplied strictly for research use only.

Context (general)

• In drug discovery workflows, small molecules such as XMU-MP-9 may be employed as tool compounds for target/pathway validation, assay development, and comparative benchmarking alongside proprietary leads. Such use is preclinical and non-clinical.
• Excipient or formulation roles are not applicable to this product.

Guidance

• If you intend to use this compound as an internal control in preclinical studies, confirm identity, purity, and stability via CoA and in-house analytics, and document storage/handling to ensure data integrity.
• No pharmacopeial monograph or GMP status is indicated in the Product Data.

Physical Properties

The Product Data for this item does not list explicit physical constants.

Item-specific data

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point, boiling point, density, refractive index, pKa, logP/logD, UV-Vis cutoff: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet.

General handling considerations for small-molecule screening compounds (informational)

• Stock solutions are commonly prepared in anhydrous DMSO at 10–50 mM (literature/general practice), followed by dilution into assay media. Actual solubility must be verified experimentally for this lot.
• Light sensitivity: The storage guidance (“Protected from light”) indicates potential photolability; minimize exposure to ambient/UV light during weighing and solution prep.
• Thermal sensitivity: Storage at −80 °C suggests improved long-term stability at cryogenic temperature; avoid prolonged bench-time of solid or solutions.

Recommendations

• Prior to assay deployment, confirm solubility and stability in your target vehicle by a small-scale test (visual inspection, HPLC/UPLC check for degradation, and concentration verification).
• If UV-based quantification is planned, determine the compound’s extinction coefficient and practical detection wavelength from your own spectra or literature before relying on absorbance calibration.
• Always defer to the current CoA and SDS for authoritative, item-specific physical data.

Quality and Grades

Grade/Purity listing: Moligand™.

About Moligand™ (general description)

• Moligand™ designates Aladdin’s small-molecule screening/library line intended for research discovery workflows (e.g., target validation, pathway interrogation, chemogenomic studies). Compounds are supplied for research use only.

What this means for users

• Screening utility: Materials are prepared and packaged to support HTS and medicinal chemistry workflows (e.g., inert gas headspace, light protection when appropriate) as indicated by the storage directions.
• Documentation: For any lot-specific specifications—purity method/basis (HPLC/LC-MS/NMR), residual solvents, water content, salt form, and counterions—refer to the current CoA/Spec Sheet. If your application requires specific analytical criteria (e.g., low UV background for biochemical assays), please verify with QC data before use.
• Stabilization: The listing notes “Protected from light, Argon charged,” indicating attention to oxidative and photolytic stability. No additional stabilizers are claimed in the Product Data.

Best practices

• Upon receipt, inspect packaging integrity, verify the SKU/lot, and archive the CoA. If you aliquot solids or DMSO stocks, label with concentration, date, and lot to preserve traceability across experiments.
• For analytical reference or registration-grade work, consider in-house orthogonal confirmation (e.g., LC-MS, 1H/13C NMR) against the CoA.

Note

• Specific numerical specifications (purity %, water ppm, metal limits, UV cutoff) are not provided here; consult the CoA/Spec Sheet.

Reaction and Applications

This product is supplied as a bioactive small-molecule research reagent and is not typically used as a synthetic reagent or solvent.

• Synthetic reaction applications (e.g., as a coupling partner, catalyst, or solvent) are not generally applicable for this item.
• For users employing this compound as a biological tool (e.g., pathway interrogation, phenotypic screening), please see the Biological Roles, Application Protocols, and Storage & Reconstitution sections for practical guidance.

If your project involves derivatization or probe synthesis using this scaffold, consult the CoA/Spec Sheet to confirm the exact structure and functional handles before planning synthetic steps.

Reaction Conditions

Not typically applicable. This product is not offered as a reagent or catalyst for chemical synthesis, and the Product Data does not include reaction condition guidance.

If you intend to use the compound as a substrate for derivatization

• Confirm structure and functional handles from the CoA before planning transformations.
• Establish small-scale test reactions to probe stability toward acids/bases, oxidants/reductants, and heating, using analytical follow-up (LC-MS, HPLC).

For biological assays

• See Solvent Selection and Storage & Reconstitution for practical guidance on solution preparation, dilution, and handling.

Safety and Handling

Hazard classification for this specific SKU is not listed in the Product Data; consult the SDS for definitive information.

Item-specific hazard data

• Signal word: Not specified for this item; refer to SDS.
• H-statements: Not specified for this item; refer to SDS.
• GHS classification and pictograms: Not specified for this item; refer to SDS.

General laboratory precautions (informational; not a substitute for SDS)

• PPE: Use lab coat, safety glasses, and appropriate chemically resistant gloves. Work in a fume hood to minimize inhalation exposure from powders or solvent vapors.
• Avoid ingestion, inhalation of dust/aerosols, and skin/eye contact. Wash thoroughly after handling.
• Incompatibilities: Without a defined functional group set, treat as an organic compound of unknown hazard. Keep away from strong oxidizers and sources of ignition. Follow inert-atmosphere handling consistent with the storage directive (argon charged).
• Photolability: Protect from light during weighing, transfer, and storage.
• First aid (overview): In case of skin/eye contact, rinse with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air; if ingested, do not induce vomiting—seek medical attention. Bring SDS to the provider.

Waste and spill response

• Collect spills with inert absorbent; place waste in a sealed, compatible container for disposal according to institutional and local regulations.

Authoritative source

• Always defer to the current SDS and institutional EHS guidelines for risk assessment and handling procedures.

Solvent Selection

Item-specific solvent compatibility is not provided in the Product Data. The storage conditions (argon charged, protected from light, −80 °C) suggest formulating under low-oxygen, low-light conditions.

General guidance for small-molecule tool compounds (informational)

• Primary vehicle: Anhydrous DMSO is commonly used for initial stock solutions due to broad solvency and assay compatibility at ≤0.5% v/v in many biological assays. Verify solubility empirically.
• Secondary vehicles: If DMSO is suboptimal, consider DMF or ethanol for intermediate concentrates, followed by dilution into aqueous buffer containing a small percentage of co-solvent or surfactant (e.g., 0.01–0.1% non-ionic surfactant) as allowed by your assay.
• Aqueous buffers: Direct dissolution into water or PBS may result in precipitation for hydrophobic compounds—titrate solvent percentage carefully and confirm by visual inspection and LC.

Comparison considerations (general)

• DMSO vs DMF: DMSO typically offers better biocompatibility in cell-based assays; DMF can improve solubility for some chemotypes but is less favored biologically.
• Ethanol: Useful for rapid screening but has stronger effects on membrane integrity above ~0.5–1% v/v.

Practical tips

• Filter sterilize solutions if required by the assay, using solvent-compatible membranes.
• Minimize freeze–thaw cycles by aliquoting stocks.
• Perform light-protected handling (amber vials, foil wrap) per the item’s storage guidance.

Storage and Reconstitution

Item-specific storage and shipping conditions

• Storage Conditions: Protected from light, Argon charged, Store at −80 °C.
• Shipped In: Dry ice packs + Cold packs.

Practical guidance

• Upon receipt: Keep the product cold and protected from light. Allow containers to equilibrate to room temperature in a desiccated, light-protected environment before opening to prevent moisture condensation.
• Inert atmosphere: The “Argon charged” note indicates oxygen/moisture sensitivity. When feasible, open and aliquot under inert gas (Ar/N2) using dry tools and vials.
• Reconstitution: If a solution is required, prepare a concentrated stock in anhydrous, oxygen-free solvent (commonly DMSO for bioassays). Record concentration, solvent, and date on each aliquot.
• Aliquoting: Divide into single-use volumes to avoid repeated freeze–thaw cycles. Store aliquots at −80 °C in amber vials or wrapped in foil to minimize photodegradation.
• Freeze–thaw: Minimize cycles. Thaw on ice or at room temperature quickly, use promptly, and refreeze unused aliquots only once if absolutely necessary.
• Stability: No item-specific stability data are provided. Verify stability of your stock solutions periodically by LC/HPLC.

Documentation

• Retain the CoA/Spec Sheet and SDS with your records. For long-term projects, document lot numbers and storage history to ensure reproducibility.

Research Use Note

• For research use only.

Structure and Identity

XMU-MP-9 is a cataloged small-molecule research reagent supplied under Aladdin’s Moligand™ line. Item-specific structural identifiers are not provided in the Product Data for this SKU.

• Name: XMU-MP-9 (catalog/inventory name)
• CAS: 2251130-41-1
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Structural features

• Item-specific structural description is not provided. For definitive structural attributes (ring systems, functional groups, stereochemistry), consult the Certificate of Analysis (CoA), Spec Sheet, or primary literature associated with the CAS.

Notes on identity sources

• If your work requires unambiguous structure confirmation (e.g., for screening library registration or analytical reference), request the current CoA/Spec Sheet and verify against your internal database before use.
• This product is intended for research use only; no pharmacopoeial identity standards are claimed.

Synthetic Utility

This catalog item is provided as a bioactive small-molecule tool and is not intended as a general synthetic reagent.

• Without item-specific structural information in the Product Data, synthetic transformations, functional group compatibility, or derivatization strategies cannot be reliably outlined.
• If you plan scaffold modifications (e.g., SAR exploration or probe derivatization), obtain the CoA/Spec Sheet to confirm the exact structure and any salt/counterion. Perform standard compatibility assessments (e.g., sensitivity to base/acid, redox conditions) on small scale before committing to route design.

For synthetic chemists

• Consider establishing an analytical baseline (1H/13C NMR, HRMS, LC-MS, HPLC purity) for the received lot. This ensures traceability if you subsequently use the material as a starting point for analog synthesis.

Target Specificity

Item-specific target specificity data are not provided in the Product Data for this SKU.

• No antigen/epitope, clone, or isotype information applies (this is not an antibody).
• For users referencing the literature: any mention of molecular targets or selectivity (e.g., kinases within the Hippo pathway) should be treated as general background. Verify activity and selectivity under your assay conditions with appropriate controls and orthogonal readouts.

Häufig gestellte Fragen

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C, protected from light, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2251130-41-1, the molecular formula is C19H13ClFN3OS, and the molecular weight is 385.84 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.