XPC-6444 - ≥99% , CAS No.2230144-21-3

CAS: 2230144-21-3 Cat. No.: X648985 Summenformel: C₂₂H₂₅F₃N₄O₂S₂ Molekulargewicht: 498.58

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant Na V 1.6 inhibitor ( IC 50 =41 nM for hNa V 1.6). XPC-6444 also displays potent block of Na V 1.2 (IC 50 =125 nM). XPC-6444 shows anticonvulsant activity

In Vitro

XPC-6444 shows high selectivity over Na V 1.1 and Na V 1.5. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 41 nM (hNa V 1.6), 125 nM (hNa V 1.2)

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant Na V 1.6 inhibitor ( IC 50 =41 nM for hNa V 1.6). XPC-6444 also displays potent block of Na V 1.2 (IC 50 =125 nM). XPC-6444 shows anticonvulsant activity.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Namen und Kennungen

• Molekulargewicht: 498.58

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 125 mg/mL (250.71 mM; Need ultrasonic)