Zaltoprofen - 10mM in DMSO , CAS No.74711-43-6

CAS: 74711-43-6 Cat. No.: Z407872 Summenformel: C₁₇H₁₄O₃S Molekulargewicht: 298.36 EG-Nummer: 277-973-5 PubChem CID: 5720

GRADE & PURITY 10mM in DMSO

Synonyms

10,​11-​dihydro-​α-​methyl-​10-​oxo-dibenzo[b,​f]​thiepin-​2-​acetic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Zaltoprofen is an inhibitor ofCOX-1andCOX-2for treatment of arthritis.
In vitro

Zaltoprofen binds to specific sites on the protein of the bradykinin B2 receptor, hence we have examined the effect of zaltoprofen on bradykinin-induced responses of adult DRG neurons to investigate possible interaction sites. Zaltoprofen most potently inhibits bradykinin-enhancement of capsaicin-induced Ca²⁺ uptake into DRG neurons. Zaltoprofen also significantly inhibits bradykinin-induced 12-lipoxygenase (12-LOX) activity and the slow bradykinin-induced onset of substance P release from DRG neurons. Zaltoprofen produces an analgesic action on bradykinin-induced nociceptive responses by blocking the B(2) receptor-mediated pathway in the primary sensory neurons. Zaltoprofen completely inhibits the bradykinin-induced increase of [Ca(2+)](i), which is inhibited by B(2) antagonist D-Arg-[Hyp(3), Thi(5,8), D-Phe(7)]-bradykinin, but not by B(1) antagonist. Zaltoprofen at 1nmol shows strong analgesic action on BK (i.pl.)-induced nociceptive flexor responses, whereas loxoprofen or its active metabolite loxoprofen-SRS does not. Zaltoprofen also inhibits the nociception induced by [Tyr8]-BK, a specific agonist of B2-type BK receptor, but does not affect the nociception by [Lys-des-Arg9]-BK, a specific agonist of B1-type BK receptor. Zaltoprofen is a non-steroidal anti-inflammatory drug (NSAID) causes potent inhibition of cyclooxygenase-2 with fewer side effects on the gastrointestinal tract.

In vivo

Zaltoprofen improves the loss in body weight in both Con A-treated mice and carbon tetrachloride-treated rats. Zaltoprofen (10 mg/kg) administrated at 8 h after Con A treatment is found to inhibit the Con A-induced reduction in body weight. Zaltoprofen (10 mg/kg) combined with Con A results in four times greater food intake than that in mice treated with only Con A.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

10,​11-​dihydro-​α-​methyl-​10-​oxo-dibenzo[b,​f]​thiepin-​2-​acetic acid

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Zaltoprofen is an inhibitor of COX-1 and COX-2 for treatment of arthritis.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

• Isomere SMILES: CC(C1=CC2=C(C=C1)SC3=CC=CC=C3C(=O)C2)C(=O)O
• RTECS: HQ2526700
• Alternative CAS-Nummer: 74711-43-6
• PubChem CID: 5720
• Molekulargewicht: 298.36
• Reaxy-Rn: 6770548

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 0.01 mg/mL (0.04 mM); Water: Insoluble; Ethanol: Insoluble
• Schmelzpunkt (°C): 137 °C

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 74711-43-6, the molecular formula is C17H14O3S, and the molecular weight is 298.36 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.