≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Übersicht
Zelnecirnon (RPT193) is an orally active inhibitor of CCR4 , blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. Zelnecirnon can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research
In Vitro
Zelnecirnon (1 nM-10 μM) inhibits Th2 cells chemotaxis or migration with IC 50 s of ~370 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Zelnecirnon (100 mg/kg; p.o.; once daily; 2 d, 1 d before OVA-challenge) reduces skin inflammation in an acute ovalbumin (OVA)-induced atopic dermatitis model in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Acute ovalbumin (OVA)-induced atopic dermatitis model in mouseDosage: 100 mg/kg Administration: Oral gavage; once daily; for 2 days, started 1 day before OVA-challenge (in mouse ear) Result: Decreased the ear thickness significantly.
Form:Solid
IC50& Target:CCR4
Specifications
Spezifikationen & Reinheit
≥99%
Biochemische und physiologische Mechanismen
Zelnecirnon (RPT193) is an orally active inhibitor of CCR4 , blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. Zelnecirnon can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research.
Storage
Store at -20°C
Verschickt in
Ice chest + Ice pads
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