ZLY06 , CAS No.2834727-04-5
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Z1427357
ZLY06 is an orally active dual agonist of peroxisome proliferator-activated receptor ( PPAR ) δ and γ ( PPAR δ: EC 50 =341 nM; PPAR γ: EC 50 =237 nM). ZLY06 induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1 , mediating the upregulation of CD36. In addition, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, and alleviates fatty liver by promoting β-oxidation of fatty acids and inhibiting hepatic lipogenesis.
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| CAS | 2834727-04-5 |
|---|---|
| Storage | Store at -20°C |
| Verschickt in | Ice chest + Ice pads |
| Product Description | ZLY06 is an orally active dual agonist of peroxisome proliferator-activated receptor ( PPAR ) δ and γ ( PPAR δ: EC 50 =341 nM; PPAR γ: EC 50 =237 nM). ZLY06 induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1 , mediating the upregulation of CD36. In addition, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, and alleviates fatty liver by promoting β-oxidation of fatty acids and inhibiting hepatic lipogenesis. |
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