Cathepsin

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  1. Leupeptin
    CAS: 103476-89-7 EC Number: 600-443-5 PubChem CID: 2733491 Formula: C20H38N6O4·1/2(H2SO4) Molecular Weight: 475.59
    Liquid EnzymoPure™ ? EnzymoPure™ — Aladdin's line of high-quality enzymatic solutions. Use when enzyme purity and defined activity drive assay or process performance. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L420424
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    IUPAC Name
    (2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide;sulfuric acid
    SMILES
    CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O
    InChIKey
    CIPMKIHUGVGQTG-VFFZMTJFSA-N
    InChI
    1S/2C20H38N6O4.H2O4S/c2*1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h2*11-13,15-17H,6-10H2,1-5H3,(H,24,show more
    Synonyms
    Leupeptin hemisulfate|103476-89-7|Leupeptin hemisulfate anhydrous|UNII-05V9Y5208M|05V9Y5208M|L-Leucinamide, N-acetyl-...
  2. N-Ethylmaleimide(NEM)
    CAS: 128-53-0 EC Number: 204-892-4 Formula: C6H7NO2 Molecular Weight: 125.13
    Liquid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: N421143
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    IUPAC Name
    1-ethylpyrrole-2,5-dione
    SMILES
    CCN1C(=O)C=CC1=O
    InChIKey
    HDFGOPSGAURCEO-UHFFFAOYSA-N
    InChI
    1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
    Synonyms
    NEM | maleic acid N-ethylimide | NSC92547 | NSC-92547 | USAF B-121 | ethylmaleimide | HSCI1_000382 | N-ethylmaleimide...
  3. Odanacatib (MK-0822), Inhibitor of cathepsin K;Inhibitor of cathepsin S;Inhibitor of cathepsin Z
    CAS: 603139-19-1 EC Number: 682-460-8 Formula: C25H27F4N3O3S Molecular Weight: 525.56
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: O127742
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    IUPAC Name
    (2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
    SMILES
    CC(C)(CC(C(=O)NC1(CC1)C#N)NC(C2=CC=C(C=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(F)(F)F)F
    InChIKey
    FWIVDMJALNEADT-SFTDATJTSA-N
    InChI
    1S/C25H27F4N3O3S/c1-23(2,26)14-20(22(33)32-24(15-30)12-13-24)31-21(25(27,28)29)18-6-4-16(5-7-18)17-8-10-19(11-9-17)36(3,34)35/h4-11,20-21,31H,12-14H2,show more
    Synonyms
    NSC-82320 | Odanacatib | (2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfony...
  4. Papain
    CAS: 9001-73-4 EC Number: 232-627-2 Formula:
    EnzymoPure™ ? EnzymoPure™ — Aladdin's line of high-quality enzymatic solutions. Use when enzyme purity and defined activity drive assay or process performance. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: P426757
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    Accession #
    P00784
    Synonyms
    9001-73-4|2-(3-azaniumylpropanoylamino)-3-(1H-imidazol-5-yl)propanoate
  5. MeOSuc-AAPV-CMK
    CAS: 65144-34-5 Formula: C22H35ClN4O7 Molecular Weight: 502.99
    ● In Stock — US warehouse, ships to EU* Item #: S274813
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    IUPAC Name
    methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]aminoshow more
    SMILES
    CC(C)C(C(=O)CCl)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(C)NC(=O)CCC(=O)OC
    InChIKey
    PJGDFLJMBAYGGC-XLPNERPQSA-N
    InChI
    1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,2show more
    Synonyms
    Elastase Inhibitor III | N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone | N-(Methoxysuccinyl)-L-alanyl-L-ala...
  6. Z-FA-FMK
    CAS: 197855-65-5 Formula: C21H23FN2O4 Molecular Weight: 386.42
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: Z422402
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    IUPAC Name
    benzyl N-[(2S)-1-[(4-fluoro-3-oxobutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamate
    SMILES
    CC(C(=O)CF)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2
    InChIKey
    ASXVEBPEZMSPHB-PKHIMPSTSA-N
    InChI
    1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15?,18-/show more
    Synonyms
    SW219108-1 | UNII-34O3P3306Z | DTXSID1063801 | C21H23FN2O4 | EX-A2188 | acs.jmedchem.1c00409_ST.646 | Z-FA-FMK | Zfa-...
  7. Z-Phe-Phe-FMK
    CAS: 108005-94-3 PubChem CID: 16760359 Formula: C27H27FN2O4 Molecular Weight: 462.5
    ◐ .Made to order · 8–12 wks Item #: P275793
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    IUPAC Name
    benzyl N-[1-[(4-fluoro-3-oxo-1-phenylbutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamate
    SMILES
    C1=CC=C(C=C1)CC(C(=O)CF)NC(=O)C(CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3
    InChIKey
    CAILNONEKASNSH-UHFFFAOYSA-N
    InChI
    1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(Hshow more
  8. ONO-5334
    CAS: 868273-90-9 PubChem CID: 11582982 Formula: C21H34N4O4S Molecular Weight: 438.58
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: O612515
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    IUPAC Name
    N-[(1S)-3-[(2Z)-2-[(4R)-3,4-dimethyl-1,3-thiazolidin-2-ylidene]hydrazinyl]-1-(oxan-4-yl)-2,3-dioxopropyl]cycloheptanecarboxamide
    SMILES
    CC1CSC(=NNC(=O)C(=O)C(C2CCOCC2)NC(=O)C3CCCCCC3)N1C
    InChIKey
    BTZCSXIUAFVRTE-CHGLIHOBSA-N
    InChI
    1S/C21H34N4O4S/c1-14-13-30-21(25(14)2)24-23-20(28)18(26)17(15-9-11-29-12-10-15)22-19(27)16-7-5-3-4-6-8-16/h14-17H,3-13H2,1-2H3,(H,22,27)(H,23,28)/b24-show more
    Synonyms
    N-[(1S)-3-[(2Z)-2-[(4R)-3,4-Dimethyl-1,3-thiazolidin-2-ylidene]hydrazinyl]-1-(oxan-4-yl)-2,3-dioxopropyl]cycloheptane...
  9. VBY-825, Inhibitor of cathepsin B;Inhibitor of cathepsin F;Inhibitor of cathepsin L;Inhibitor of cathepsin S;Inhibitor of cathepsin V
    CAS: 1310340-58-9 Formula: C23H29F4N3O5S Molecular Weight: 535.55
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: V614715
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    IUPAC Name
    (3S)-N-cyclopropyl-3-[[(2R)-3-(cyclopropylmethylsulfonyl)-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propanoyl]amino]-2-oxopentanamide
    SMILES
    CCC(C(=O)C(=O)NC1CC1)NC(=O)C(CS(=O)(=O)CC2CC2)NC(C3=CC=C(C=C3)F)C(F)(F)F
    InChIKey
    PPUXXDKQNAHHON-BJLQDIEVSA-N
    InChI
    1S/C23H29F4N3O5S/c1-2-17(19(31)22(33)28-16-9-10-16)30-21(32)18(12-36(34,35)11-13-3-4-13)29-20(23(25,26)27)14-5-7-15(24)8-6-14/h5-8,13,16-18,20,29H,2-4show more
    Synonyms
    (3S)-N-cyclopropyl-3-[[(2R)-3-(cyclopropylmethylsulfonyl)-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]prop...
  10. relacatib, Inhibitor of cathepsin K
    CAS: 362505-84-8 EC Number: 838-013-6 PubChem CID: 6918602
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: R613122
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    IUPAC Name
    N-[(2S)-4-methyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopentan-2-yl]-1-benzofuran-2-carboxamide
    SMILES
    CC1CCC(C(=O)CN1S(=O)(=O)C2=CC=CC=N2)NC(=O)C(CC(C)C)NC(=O)C3=CC4=CC=CC=C4O3
    InChIKey
    BWYBBMQLUKXECQ-GIVPXCGWSA-N
    InChI
    1S/C27H32N4O6S/c1-17(2)14-21(30-27(34)24-15-19-8-4-5-9-23(19)37-24)26(33)29-20-12-11-18(3)31(16-22(20)32)38(35,36)25-10-6-7-13-28-25/h4-10,13,15,17-18show more
    Synonyms
    BDBM19778 | BL51M8CB8R | GSK-462795 | Benzofuran-2-carboxylic acid {(S)-3-methyl-1-[(4S,7R)-7-methyl-3-oxo-1-(pyridin...
  11. cathepsin G
    CAS: 107200-92-0
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .US Made to order · 2–4 wks Item #: rp173626
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  12. KGP94, Inhibitor of cathepsin L
    CAS: 1131456-28-4 PubChem CID: 52944285
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: K611333
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    Technical Identifiers
    IUPAC Name
    [(E)-[(3-bromophenyl)(3-hydroxyphenyl)methylidene]amino]thiourea
    SMILES
    NC(=S)N/N=C(/c1cccc(c1)Br)\c1cccc(c1)O
    InChIKey
    ZDBKSZKTCPOBFR-LGMDPLHJSA-N
    InChI
    1S/C14H12BrN3OS/c15-11-5-1-3-9(7-11)13(17-18-14(16)20)10-4-2-6-12(19)8-10/h1-8,19H,(H3,16,18,20)/b17-13-
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Frequently Asked Questions

What can I find under Cathepsin?
This listing collects compounds associated with Cathepsin within our Metabolic Enzyme/Protease area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for Cathepsin?
Consider the reported potency of each Cathepsin compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for Cathepsin compounds?
Each Cathepsin product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search Cathepsin compounds by activity or structure?
Yes. Filter the Cathepsin listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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