CDK

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  1. MeBIO
    CAS: 667463-95-8 Formula: C17H12BrN3O2 Molecular Weight: 370.2
    ● In Stock — US warehouse, ships to EU* Item #: M286848
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    IUPAC Name
    6-bromo-1-methyl-3-(3-nitroso-1H-indol-2-yl)indol-2-ol
    SMILES
    CN1C2=C(C=CC(=C2)Br)C(=C1O)C3=C(C4=CC=CC=C4N3)N=O
    InChIKey
    PIDGGJYETVQYET-UHFFFAOYSA-N
    InChI
    1S/C17H12BrN3O2/c1-21-13-8-9(18)6-7-11(13)14(17(21)22)16-15(20-23)10-4-2-3-5-12(10)19-16/h2-8,19,22H,1H3
    Synonyms
    AKOS024457840 | (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime | SMP2_000213 | MeBIO | SCHEMBL18837022 | MS-25947 | HMS...
  2. NG 52, Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta
    CAS: 212779-48-1 EC Number: 690-619-8 Formula: C16H19ClN6O Molecular Weight: 346.81
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: N413510
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    IUPAC Name
    2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
    SMILES
    CC(C)N1C=NC2=C(N=C(N=C21)NCCO)NC3=CC(=CC=C3)Cl
    InChIKey
    XZEFMZCNXDQXOZ-UHFFFAOYSA-N
    InChI
    1S/C16H19ClN6O/c1-10(2)23-9-19-13-14(20-12-5-3-4-11(17)8-12)21-16(18-6-7-24)22-15(13)23/h3-5,8-10,24H,6-7H2,1-2H3,(H2,18,20,21,22)
    Synonyms
    Ethanol,2-​[[6-​[(3-​chlorophenyl)​amino]​-​9-​(1-​methylethyl)​-​9H-​purin-​2-​yl]​amino]​-
  3. NG 52, Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta
    CAS: 212779-48-1 EC Number: 690-619-8 Formula: C16H19ClN6O Molecular Weight: 346.81
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: N422573
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    IUPAC Name
    2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
    SMILES
    CC(C)N1C=NC2=C(N=C(N=C21)NCCO)NC3=CC(=CC=C3)Cl
    InChIKey
    XZEFMZCNXDQXOZ-UHFFFAOYSA-N
    InChI
    1S/C16H19ClN6O/c1-10(2)23-9-19-13-14(20-12-5-3-4-11(17)8-12)21-16(18-6-7-24)22-15(13)23/h3-5,8-10,24H,6-7H2,1-2H3,(H2,18,20,21,22)
    Synonyms
    212779-48-1|NG 52|compound 52|NG-52|2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE|2-((6-((3-chlorophe...
  4. NVP 2, Inhibitor of cyclin dependent kinase 9
    CAS: 1263373-43-8 Formula: C27H37ClN6O2 Molecular Weight: 513.07
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: N421103
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    IUPAC Name
    4-[[[6-[5-chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]oxane-4-carbonitrile
    SMILES
    CC(COC)NC1CCC(CC1)NC2=NC=C(C(=C2)C3=NC(=CC=C3)NCC4(CCOCC4)C#N)Cl
    InChIKey
    XWQVQSXLXAXOPJ-QNGMFEMESA-N
    InChI
    1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6show more
    Synonyms
    4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]...
  5. NU 2058
    CAS: 161058-83-9 EC Number: 633-908-6 Formula: C12H17N5O Molecular Weight: 247.3
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: N421939
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    IUPAC Name
    6-(cyclohexylmethoxy)-7H-purin-2-amine
    SMILES
    C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)N
    InChIKey
    MWGXGTJJAOZBNW-UHFFFAOYSA-N
    InChI
    1S/C12H17N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H3,13,14,15,16,17)
    Synonyms
    CCG-222242 | O(6)-cyclohexylmethylguanine | O-Cyclohexylmethylguanine | Tox21_500938 | SMR000568417 | 6-Cyclohexylmet...
  6. NU6027
    CAS: 220036-08-8 Formula: C11H17N5O2 Molecular Weight: 251.28
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: N422642
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    IUPAC Name
    6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
    SMILES
    C1CCC(CC1)COC2=NC(=NC(=C2N=O)N)N
    InChIKey
    DGWXOLHKVGDQLN-UHFFFAOYSA-N
    InChI
    1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
    Synonyms
    6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine | A14136 | DGWXOLHKVGDQLN-UHFFFAOYSA-N | NCI60_038218 | pyrimid...
  7. ON-123300, Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 6;Inhibitor of NUAK family kinase 1
    CAS: 1357470-29-1 Formula: C24H27N7O Molecular Weight: 429.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: O421359
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    IUPAC Name
    8-cyclopentyl-2-[4-(4-methylpiperazin-1-yl)anilino]-7-oxopyrido[2,3-d]pyrimidine-6-carbonitrile
    SMILES
    CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C=C(C(=O)N(C4=N3)C5CCCC5)C#N
    InChIKey
    VADOZMZXXRBXNY-UHFFFAOYSA-N
    InChI
    1S/C24H27N7O/c1-29-10-12-30(13-11-29)20-8-6-19(7-9-20)27-24-26-16-18-14-17(15-25)23(32)31(22(18)28-24)21-4-2-3-5-21/h6-9,14,16,21H,2-5,10-13H2,1H3,(H,show more
    Synonyms
    ON123300|1357470-29-1|ON-123300|narazaciclib|8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihy...
  8. OTS964
    CAS: 1338545-07-5 Formula: C23H24N2O2S.HCl Molecular Weight: 428.97
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: O421282
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    IUPAC Name
    9-[4-[(2R)-1-(dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one;hydrochloride
    SMILES
    CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)C(C)CN(C)C)O.Cl
    InChIKey
    YHPWOYBWUWSJDW-UQKRIMTDSA-N
    InChI
    1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17-9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-;show more
    Synonyms
    SCHEMBL15092325 | OTS964 hydrochloride | AKOS030526420 | C72349 | 9-[4-[(2R)-1-(dimethylamino)propan-2-yl]phenyl]-8-h...
  9. OTS964 hydrochloride
    CAS: 1338545-07-5 Formula: C23H24N2O2S.HCl Molecular Weight: 428.97
    ● In Stock — US warehouse, ships to EU* Item #: O413802
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    Technical Identifiers
    IUPAC Name
    9-[4-[(2R)-1-(dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one;hydrochloride
    SMILES
    CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)C(C)CN(C)C)O.Cl
    InChIKey
    YHPWOYBWUWSJDW-UQKRIMTDSA-N
    InChI
    1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17-9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-;show more
    Synonyms
    SCHEMBL15092325 | OTS964 hydrochloride | AKOS030526420 | C72349 | 9-[4-[(2R)-1-(dimethylamino)propan-2-yl]phenyl]-8-h...
  10. PD0332991 HCl
    CAS: 827022-32-2 Formula: C24H29N7O2·HCl Molecular Weight: 483.99
    10mM in Water
    ● In Stock — US warehouse, ships to EU* Item #: P426139
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    Technical Identifiers
    IUPAC Name
    6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;hydrochloride
    SMILES
    CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl
    InChIKey
    STEQOHNDWONVIF-UHFFFAOYSA-N
    InChI
    1S/C24H29N7O2.ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;/h7-8,13-14,17,25H,3-6,9-1show more
    Synonyms
    FT-0700370 | Palbociclib (hydrochloride) | PD-0332991 hydrochloride | AKOS000120736 | Pyrido(2,3-d)pyrimidin-7(8H)-on...
  11. Palbociclib isethionate
    CAS: 827022-33-3 EC Number: 804-556-2 Formula: C24H29N7O2·C2H6O4S Molecular Weight: 573.66
    10mM in Water
    ● In Stock — US warehouse, ships to EU* Item #: P426140
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    Technical Identifiers
    IUPAC Name
    6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;2-hydroxyethanesulfonic acid
    SMILES
    CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O
    InChIKey
    LYYVFHRFIJKPOV-UHFFFAOYSA-N
    InChI
    1S/C24H29N7O2.C2H6O4S/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;3-1-2-7(4,5)6/h7-8,13-show more
    Synonyms
    tert-butoxycarbonyl homopiperazine | 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[...
  12. Pemrametostat (GSK3326595), Protein arginine N-methyltransferase 5 inhibitor
    CAS: 1616392-22-3 Formula: C24H32N6O3 Molecular Weight: 452.55
    ● In Stock — US warehouse, ships to EU* Item #: P414102
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    IUPAC Name
    6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide
    SMILES
    CC(=O)N1CCC(CC1)NC2=NC=NC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)O
    InChIKey
    JLCCNYVTIWRPIZ-NRFANRHFSA-N
    InChI
    1S/C24H32N6O3/c1-17(31)30-10-7-20(8-11-30)28-23-12-22(26-16-27-23)24(33)25-13-21(32)15-29-9-6-18-4-2-3-5-19(18)14-29/h2-5,12,16,20-21,32H,6-11,13-15H2show more
    Synonyms
    4-pyrimidinecarboxamide, 6-((1-acetyl-4-piperidinyl)amino)-N-(3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl)- |...
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Frequently Asked Questions

What can I find under CDK?
This listing collects compounds associated with CDK within our Cell Cycle/DNA Damage area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for CDK?
Consider the reported potency of each CDK compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for CDK compounds?
Each CDK product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search CDK compounds by activity or structure?
Yes. Filter the CDK listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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