CDK

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  1. JSH-150
    CAS: 2247481-21-4 Formula: C24H33ClN6O2S Molecular Weight: 505.08
    ● In Stock — US warehouse, ships to EU* Item #: J414178
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    IUPAC Name
    4-[[[4-[5-chloro-2-[[4-(2-methoxyethylamino)cyclohexyl]amino]pyridin-4-yl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrile
    SMILES
    COCCNC1CCC(CC1)NC2=NC=C(C(=C2)C3=CSC(=N3)NCC4(CCOCC4)C#N)Cl
    InChIKey
    XSDZPPRQLIZLDG-UHFFFAOYSA-N
    InChI
    1S/C24H33ClN6O2S/c1-32-11-8-27-17-2-4-18(5-3-17)30-22-12-19(20(25)13-28-22)21-14-34-23(31-21)29-16-24(15-26)6-9-33-10-7-24/h12-14,17-18,27H,2-11,16H2,show more
    Synonyms
    2H-​Pyran-​4-​carbonitrile,4-​[[[4-​[5-​chloro-​2-​[[trans-​4-​[(2-​methoxyethyl)​amino]​cyclohexyl]​amino]​-​4-​pyri...
  2. JSH-150
    CAS: 2247481-21-4 Formula: C24H33ClN6O2S Molecular Weight: 505.08
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: J422703
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    Technical Identifiers
    IUPAC Name
    4-[[[4-[5-chloro-2-[[4-(2-methoxyethylamino)cyclohexyl]amino]pyridin-4-yl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrile
    SMILES
    COCCNC1CCC(CC1)NC2=NC=C(C(=C2)C3=CSC(=N3)NCC4(CCOCC4)C#N)Cl
    InChIKey
    XSDZPPRQLIZLDG-UHFFFAOYSA-N
    InChI
    1S/C24H33ClN6O2S/c1-32-11-8-27-17-2-4-18(5-3-17)30-22-12-19(20(25)13-28-22)21-14-34-23(31-21)29-16-24(15-26)6-9-33-10-7-24/h12-14,17-18,27H,2-11,16H2,show more
    Synonyms
    2H-​Pyran-​4-​carbonitrile,4-​[[[4-​[5-​chloro-​2-​[[trans-​4-​[(2-​methoxyethyl)​amino]​cyclohexyl]​amino]​-​4-​pyri...
  3. Kenpaullone, Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5;Inhibitor of glycogen synthase kinase 3 beta
    CAS: 142273-20-9 EC Number: 634-310-8 Formula: C16H11BrN2O Molecular Weight: 327.18
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: K421568
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    IUPAC Name
    9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
    SMILES
    C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br
    InChIKey
    QQUXFYAWXPMDOE-UHFFFAOYSA-N
    InChI
    1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
    Synonyms
    kenpaullone|142273-20-9|9-Bromopaullone|NSC 664704|NSC-664704|9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-on...
  4. Kojic acid
    CAS: 501-30-4 EC Number: 207-922-4 Formula: C6H6O4 Molecular Weight: 142.11
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: K424322
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    IUPAC Name
    5-hydroxy-2-(hydroxymethyl)pyran-4-one
    SMILES
    C1=C(OC=C(C1=O)O)CO
    InChIKey
    BEJNERDRQOWKJM-UHFFFAOYSA-N
    InChI
    1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
    Synonyms
    AI3-02549 | HSDB 7664 | KOJIC ACID (MART.) | 2-HYDROXYMETHYL-5-HYDROXY-.GAMMA.-PYRONE | 5-Hydroxy-2-hydroxymethyl-4H-...
  5. LDC4297 (LDC044297)
    CAS: 1453834-21-3 Formula: C23H28N8O Molecular Weight: 432.52
    ● In Stock — US warehouse, ships to EU* Item #: L413901
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    Technical Identifiers
    IUPAC Name
    2-piperidin-3-yloxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine
    SMILES
    CC(C)C1=C2N=C(N=C(N2N=C1)NCC3=CC=CC=C3N4C=CC=N4)OC5CCCNC5
    InChIKey
    LSGRZENCFIIHNV-UHFFFAOYSA-N
    InChI
    1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,show more
    Synonyms
    Pyrazolo[1,​5-​a]​-​1,​3,​5-​triazin-​4-​amine,8-​(1-​methylethyl)​-​2-​(3-​piperidinyloxy)​-​N-​[[2-​(1H-​pyrazol-​1-�...
  6. LEE011-d6
    CAS: 1328934-40-2 Formula: C23H24D6N8O Molecular Weight: 440.57
    ◐ .Made to order · 8–12 wks Item #: L353979
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    IUPAC Name
    7-cyclopentyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]-N,N-bis(trideuteriomethyl)pyrrolo[2,3-d]pyrimidine-6-carboxamide
    SMILES
    CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
    InChIKey
    RHXHGRAEPCAFML-WFGJKAKNSA-N
    InChI
    1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3show more
    Synonyms
    7-Cyclopentyl-N,N-di(methyl-d3)-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide
  7. LDC 000067
    CAS: 1073485-20-7 EC Number: 860-308-3 Formula: C18H18N4O3S Molecular Weight: 370.43
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L420523
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    IUPAC Name
    [3-[[6-(2-methoxyphenyl)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
    SMILES
    COC1=CC=CC=C1C2=CC(=NC=N2)NC3=CC=CC(=C3)CS(=O)(=O)N
    InChIKey
    GGQCIOOSELPMBB-UHFFFAOYSA-N
    InChI
    1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)
    Synonyms
    BDBM50013510 | BCP10866 | 3-(2-(Dimethylamino)ethyl)-N-methylindole-5-methanesulfonamide | MFCD28137788 | 3-[[6-(2-Me...
  8. LDC4297 (LDC044297)
    CAS: 1453834-21-3 Formula: C23H28N8O Molecular Weight: 432.52
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L421672
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    Technical Identifiers
    IUPAC Name
    2-piperidin-3-yloxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine
    SMILES
    CC(C)C1=C2N=C(N=C(N2N=C1)NCC3=CC=CC=C3N4C=CC=N4)OC5CCCNC5
    InChIKey
    LSGRZENCFIIHNV-UHFFFAOYSA-N
    InChI
    1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,show more
    Synonyms
    Pyrazolo[1,​5-​a]​-​1,​3,​5-​triazin-​4-​amine,8-​(1-​methylethyl)​-​2-​(3-​piperidinyloxy)​-​N-​[[2-​(1H-​pyrazol-​1-�...
  9. LEE011 succinate, Cyclin-dependent kinase 6 inhibitor
    CAS: 1374639-75-4 EC Number: 801-486-4 Formula: C27H36N8O5 Molecular Weight: 552.63
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L421422
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    IUPAC Name
    butanedioic acid;7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
    SMILES
    CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5.C(CC(=O)O)C(=O)O
    InChIKey
    NHANOMFABJQAAH-UHFFFAOYSA-N
    InChI
    1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,show more
    Synonyms
    D10979 | Q27274660 | SB18482 | 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]...
  10. LY2857785
    CAS: 1619903-54-6 Formula: C26H36N6O Molecular Weight: 448.6
    ● In Stock — US warehouse, ships to EU* Item #: L413766
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    IUPAC Name
    4-N-[4-(2-methyl-3-propan-2-ylindazol-5-yl)pyrimidin-2-yl]-1-N-(oxan-4-yl)cyclohexane-1,4-diamine
    SMILES
    CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5
    InChIKey
    LHIUZPIDLZYPRL-UHFFFAOYSA-N
    InChI
    1S/C26H36N6O/c1-17(2)25-22-16-18(4-9-24(22)31-32(25)3)23-10-13-27-26(30-23)29-20-7-5-19(6-8-20)28-21-11-14-33-15-12-21/h4,9-10,13,16-17,19-21,28H,5-8,show more
    Synonyms
    (1r,4r)-N1-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine
  11. LY2857785
    CAS: 1619903-54-6 Formula: C26H36N6O Molecular Weight: 448.6
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: L421959
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    Technical Identifiers
    IUPAC Name
    4-N-[4-(2-methyl-3-propan-2-ylindazol-5-yl)pyrimidin-2-yl]-1-N-(oxan-4-yl)cyclohexane-1,4-diamine
    SMILES
    CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5
    InChIKey
    LHIUZPIDLZYPRL-UHFFFAOYSA-N
    InChI
    1S/C26H36N6O/c1-17(2)25-22-16-18(4-9-24(22)31-32(25)3)23-10-13-27-26(30-23)29-20-7-5-19(6-8-20)28-21-11-14-33-15-12-21/h4,9-10,13,16-17,19-21,28H,5-8,show more
    Synonyms
    1,​4-​Cyclohexanediamine,N1-​[4-​[2-​methyl-​3-​(1-​methylethyl)​-​2H-​indazol-​5-​yl]​-​2-​pyrimidinyl]​-​N4-​(tetra...
  12. LY3405105
    CAS: 2326428-25-3 Formula: C26H39N7O3 Molecular Weight: 497.63
    ● In Stock — US warehouse, ships to EU* Item #: L413667
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    Technical Identifiers
    IUPAC Name
    [1-[(E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl] 4-[(5-methyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-7-yl)amino]piperidine-1-carboxylate
    SMILES
    CC1=NC2=C(C=NN2C(=C1)NC3CCN(CC3)C(=O)OC4CCN(C4)C(=O)C=CCN(C)C)C(C)C
    InChIKey
    GRDAHPJRLCTJNA-VOTSOKGWSA-N
    InChI
    1S/C26H39N7O3/c1-18(2)22-16-27-33-23(15-19(3)28-25(22)33)29-20-8-12-31(13-9-20)26(35)36-21-10-14-32(17-21)24(34)7-6-11-30(4)5/h6-7,15-16,18,20-21,29H,show more
    Synonyms
    1-​Piperidinecarboxylic acid,4-​[[5-​methyl-​3-​(1-​methylethyl)​pyrazolo[1,​5-​a]​pyrimidin-​7-​yl]​amino]​-​,1-​[(2E)...
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Frequently Asked Questions

What can I find under CDK?
This listing collects compounds associated with CDK within our Cell Cycle/DNA Damage area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for CDK?
Consider the reported potency of each CDK compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for CDK compounds?
Each CDK product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search CDK compounds by activity or structure?
Yes. Filter the CDK listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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