Checkpoint Kinase (Chk)
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71 products
Popular Products
- Chk2 inhibitor II, Inhibitor of checkpoint kinase 2CAS: 516480-79-8 Formula: C20H14CIN3O2 Molecular Weight: 363.8Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: C275315View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide
- SMILES
- C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
- InChIKey
- UXGJAOIJSROTTN-UHFFFAOYSA-N
- InChI
- 1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
- Synonyms
- Regadenoson; CVT-3146 | Chk2 Inhibitor II | BML277 | BML-277 | HMS3745A07 | NCGC00165768-02 | NSC741899 | NSC-741899 ...
- Chk2 inhibitor II, Inhibitor of checkpoint kinase 2CAS: 516480-79-8 Formula: C20H14CIN3O2 Molecular Weight: 363.8Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: C424436View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide
- SMILES
- C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
- InChIKey
- UXGJAOIJSROTTN-UHFFFAOYSA-N
- InChI
- 1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
- Synonyms
- Regadenoson; CVT-3146 | Chk2 Inhibitor II | BML277 | BML-277 | HMS3745A07 | NCGC00165768-02 | NSC741899 | NSC-741899 ...
- GDC-0575 (ARRY-575)CAS: 1196541-47-5 Formula: C16H20BrN5O Molecular Weight: 378.27● In Stock — US warehouse, ships to EU* Item #: G414039View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[4-[(3R)-3-aminopiperidin-1-yl]-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl]cyclopropanecarboxamide
- SMILES
- C1CC(CN(C1)C2=C3C(=CNC3=NC=C2Br)NC(=O)C4CC4)N
- InChIKey
- BAZRWWGASYWYGB-SNVBAGLBSA-N
- InChI
- 1S/C16H20BrN5O/c17-11-6-19-15-13(14(11)22-5-1-2-10(18)8-22)12(7-20-15)21-16(23)9-3-4-9/h6-7,9-10H,1-5,8,18H2,(H,19,20)(H,21,23)/t10-/m1/s1
- M2I-1CAS: 312271-03-7 Formula: C19H24N4O4S Molecular Weight: 404.4810mM in DMSO● In Stock — US warehouse, ships to EU* Item #: M423212View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
- SMILES
- CC(C)CN(CC(C)C)C1=C(C=C(C=C1)C=C2C(=O)NC(=S)NC2=O)[N+](=O)[O-]
- InChIKey
- BWEKPQUKWLNUKX-UHFFFAOYSA-N
- InChI
- 1S/C19H24N4O4S/c1-11(2)9-22(10-12(3)4)15-6-5-13(8-16(15)23(26)27)7-14-17(24)20-19(28)21-18(14)25/h5-8,11-12H,9-10H2,1-4H3,(H2,20,21,24,25,28)
- Synonyms
- M2I-1|312271-03-7|MLS000572003|5-[4-(diisobutylamino)-3-nitrobenzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione|...
- M2I-1CAS: 312271-03-7 Formula: C19H24N4O4S Molecular Weight: 404.48● In Stock — US warehouse, ships to EU* Item #: M412228View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
- SMILES
- CC(C)CN(CC(C)C)C1=C(C=C(C=C1)C=C2C(=O)NC(=S)NC2=O)[N+](=O)[O-]
- InChIKey
- BWEKPQUKWLNUKX-UHFFFAOYSA-N
- InChI
- 1S/C19H24N4O4S/c1-11(2)9-22(10-12(3)4)15-6-5-13(8-16(15)23(26)27)7-14-17(24)20-19(28)21-18(14)25/h5-8,11-12H,9-10H2,1-4H3,(H2,20,21,24,25,28)
- Synonyms
- M2I-1|312271-03-7|MLS000572003|5-[4-(diisobutylamino)-3-nitrobenzylidene]-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione|...
- MK-8776 (SCH 900776), Serine/threonine-protein kinase Chk1 inhibitor● In Stock — US warehouse, ships to EU* Item #: S127483View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3R)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine
- SMILES
- CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)C4CCCNC4
- InChIKey
- GMIZZEXBPRLVIV-SECBINFHSA-N
- InChI
- 1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m1/s1
- Synonyms
- (R)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine | NSC800880 | NSC-800880 ...
- ML367CAS: 381168-77-0 Formula: C19H12F2N4 Molecular Weight: 334.32● In Stock — US warehouse, ships to EU* Item #: M412211View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- SMILES
- C1=CC=C2C(=C1)C(=NC(=N2)C3=CC=NC=C3)NC4=CC(=C(C=C4)F)F
- InChIKey
- LBPYNNJXARHGAG-UHFFFAOYSA-N
- InChI
- 1S/C19H12F2N4/c20-15-6-5-13(11-16(15)21)23-19-14-3-1-2-4-17(14)24-18(25-19)12-7-9-22-10-8-12/h1-11H,(H,23,24,25)
- ML367CAS: 381168-77-0 Formula: C19H12F2N4 Molecular Weight: 334.3210mM in DMSO● In Stock — US warehouse, ships to EU* Item #: M423760View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- SMILES
- C1=CC=C2C(=C1)C(=NC(=N2)C3=CC=NC=C3)NC4=CC(=C(C=C4)F)F
- InChIKey
- LBPYNNJXARHGAG-UHFFFAOYSA-N
- InChI
- 1S/C19H12F2N4/c20-15-6-5-13(11-16(15)21)23-19-14-3-1-2-4-17(14)24-18(25-19)12-7-9-22-10-8-12/h1-11H,(H,23,24,25)
- Prexasertib dihydrochloride● In Stock — US warehouse, ships to EU* Item #: P413719View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile;dihydrochloride
- SMILES
- COC1=C(C(=CC=C1)OCCCN)C2=CC(=NN2)NC3=NC=C(N=C3)C#N.Cl.Cl
- InChIKey
- KMEIPKXRCJTZBZ-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- LY2606368 diHCl | LY2606368 Prexasertib HCl | 9RFT476U2L | LY2606368 2HCl | EX-A758A | 2-Pyrazinecarbonitrile, 5-[[5-...
- SAR-02010610mM in DMSO● In Stock — US warehouse, ships to EU* Item #: S420813View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[(8-chloroisoquinolin-3-yl)amino]-3-[(2R)-1-(dimethylamino)propan-2-yl]oxypyrazine-2-carbonitrile
- SMILES
- CC(CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C3C(=C2)C=CC=C3Cl
- InChIKey
- SRBJWIBAMIKCMV-GFCCVEGCSA-N
- InChI
- 1S/C19H19ClN6O/c1-12(11-26(2)3)27-19-16(8-21)22-10-18(25-19)24-17-7-13-5-4-6-15(20)14(13)9-23-17/h4-7,9-10,12H,11H2,1-3H3,(H,23,24,25)/t12-/m1/s1
- Synonyms
- 5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
- SAR-020106● In Stock — US warehouse, ships to EU* Item #: S413824View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-[(8-chloroisoquinolin-3-yl)amino]-3-[(2R)-1-(dimethylamino)propan-2-yl]oxypyrazine-2-carbonitrile
- SMILES
- CC(CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C3C(=C2)C=CC=C3Cl
- InChIKey
- SRBJWIBAMIKCMV-GFCCVEGCSA-N
- InChI
- 1S/C19H19ClN6O/c1-12(11-26(2)3)27-19-16(8-21)22-10-18(25-19)24-17-7-13-5-4-6-15(20)14(13)9-23-17/h4-7,9-10,12H,11H2,1-3H3,(H,23,24,25)/t12-/m1/s1
- Synonyms
- 5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
- TCS 2312◐ .Made to order · 8–12 wks Item #: T286636View ProductPricing & Pack Sizes
Technical Identifiers
- SMILES
- OC1=CC(O)=CC=C1C2=CC=C(C3=CC(NC4=CC=C(CNC5CC5)C=C4)=NN3)C=C2
- InChIKey
- BYFCMDWKTJJQGR-UHFFFAOYSA-N
- Synonyms
- 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
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Frequently Asked Questions
Which compounds are listed for Checkpoint Kinase (Chk)?
Compounds associated with Checkpoint Kinase (Chk) are grouped here under the Cell Cycle/DNA Damage classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does Checkpoint Kinase (Chk) sit within Cell Cycle/DNA Damage?
Checkpoint Kinase (Chk) is one target listing within the Cell Cycle/DNA Damage classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from Checkpoint Kinase (Chk)?
For compounds listed under Checkpoint Kinase (Chk), check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for Checkpoint Kinase (Chk)?
Browse the parent Cell Cycle/DNA Damage listing to reach targets neighbouring Checkpoint Kinase (Chk), and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.