Checkpoint Kinase (Chk)

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  1. VRX-0466617
    CAS: 926906-64-1 PubChem CID: 25166905 Formula: C19H20BrN5O2S Molecular Weight: 462.4
    ◐ .Made to order · 8–12 wks Item #: V669798
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    Technical Identifiers
    IUPAC Name
    5-[4-(4-bromoanilino)anilino]-N'-(1-hydroxypropan-2-yl)-3-oxo-1,2-thiazole-4-carboximidamide
    SMILES
    CC(CO)NC(=N)C1=C(NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)SN=C1O
    InChIKey
    YFQDMCVTQPZMAQ-UHFFFAOYSA-N
    InChI
    1S/C19H20BrN5O2S/c1-11(10-26)22-17(21)16-18(27)25-28-19(16)24-15-8-6-14(7-9-15)23-13-4-2-12(20)3-5-13/h2-9,11,23-24,26H,10H2,1H3,(H2,21,22)(H,25,27)
  2. Ly-2880070
    CAS: 1375637-35-6 Formula: C19H23N7O2 Molecular Weight: 381.4
    ◐ .Made to order · 8–12 wks Item #: L1275888
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    IUPAC Name
    N-[5-(2-methoxy-6-methylpyridin-3-yl)-1H-pyrazol-3-yl]-6-[(3R)-piperidin-3-yl]oxypyrazin-2-amine
    SMILES
    CC1=NC(=C(C=C1)C2=CC(=NN2)NC3=CN=CC(=N3)O[C@@H]4CCCNC4)OC
    InChIKey
    LAEFIEWPUJMANC-CYBMUJFWSA-N
    InChI
    1S/C19H23N7O2/c1-12-5-6-14(19(22-12)27-2)15-8-16(26-25-15)23-17-10-21-11-18(24-17)28-13-4-3-7-20-9-13/h5-6,8,10-11,13,20H,3-4,7,9H2,1-2H3,(H2,23,24,25show more
  3. Chk1-IN-5
    CAS: 2120398-39-0 PubChem CID: 156595099
    ◐ .Made to order · 8–12 wks Item #: C1426888
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    Technical Identifiers
    IUPAC Name
    5-[[5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]pyrazolidin-3-yl]amino]pyrazine-2-carbonitrile
    SMILES
    COC1=C(C(=CC(=C1)F)OCCCN)C2CC(NN2)NC3=NC=C(N=C3)C#N
    InChIKey
    OECWXHGRBWTUAM-UHFFFAOYSA-N
    InChI
    1S/C18H22FN7O2/c1-27-14-5-11(19)6-15(28-4-2-3-20)18(14)13-7-16(26-25-13)24-17-10-22-12(8-21)9-23-17/h5-6,9-10,13,16,25-26H,2-4,7,20H2,1H3,(H,23,24)
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

Which compounds are listed for Checkpoint Kinase (Chk)?
Compounds associated with Checkpoint Kinase (Chk) are grouped here under the Cell Cycle/DNA Damage classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does Checkpoint Kinase (Chk) sit within Cell Cycle/DNA Damage?
Checkpoint Kinase (Chk) is one target listing within the Cell Cycle/DNA Damage classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from Checkpoint Kinase (Chk)?
For compounds listed under Checkpoint Kinase (Chk), check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for Checkpoint Kinase (Chk)?
Browse the parent Cell Cycle/DNA Damage listing to reach targets neighbouring Checkpoint Kinase (Chk), and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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