c-Kit

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  1. CS-2660 (JNJ-38158471)
    CAS: 951151-97-6 Formula: C15H17ClN6O3 Molecular Weight: 364.79
    10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: C427060
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    IUPAC Name
    1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea
    SMILES
    CCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC(=C2C=NOC)N)Cl
    InChIKey
    BJHCYTJNPVGSBZ-QPSGOUHRSA-N
    InChI
    1S/C15H17ClN6O3/c1-3-18-15(23)22-12-5-4-9(6-11(12)16)25-14-10(7-21-24-2)13(17)19-8-20-14/h4-8H,3H2,1-2H3,(H2,17,19,20)(H2,18,22,23)/b21-7+
    Synonyms
    Urea,N-​[4-​[[6-​amino-​5-​[(methoxyimino)​methyl]​-​4-​pyrimidinyl]​oxy]​-​2-​chlorophenyl]​-​N'-​ethyl-
  2. Cabozantinib (XL184, BMS-907351), Inhibitor of kinase insert domain receptor;Inhibitor of MET proto-oncogene; receptor tyrosine kinase;Inhibitor of ret proto-oncogene
    CAS: 849217-68-1 EC Number: 692-846-8 Formula: C28H24FN3O5 Molecular Weight: 501.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C126195
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    IUPAC Name
    1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    SMILES
    COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
    InChIKey
    ONIQOQHATWINJY-UHFFFAOYSA-N
    InChI
    1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-1show more
    Synonyms
    BDBM50021574 | N-[4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]-N inverted exclamation mark -(4-fluorophenyl)cyclopropan...
  3. DCC-2618
    CAS: 1225278-16-9 Formula: C26H21F2N5O3 Molecular Weight: 489.47
    Liquid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: D420967
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    IUPAC Name
    1-N'-[2,5-difluoro-4-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxyphenyl]-1-N-phenylcyclopropane-1,1-dicarboxamide
    SMILES
    CN1C=C(C=N1)C2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=CC=C5)F
    InChIKey
    WWOXKWLDMLMYQY-UHFFFAOYSA-N
    InChI
    1S/C26H21F2N5O3/c1-33-15-16(14-30-33)21-11-18(7-10-29-21)36-23-13-19(27)22(12-20(23)28)32-25(35)26(8-9-26)24(34)31-17-5-3-2-4-6-17/h2-7,10-15H,8-9H2,1show more
    Synonyms
    N-(2,5-Difluoro-4-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-N′-phenylcyclopropane-1,1-dicarboxamide, DCC 2...
  4. Dovitinib (TKI258) Lactate
    CAS: 915769-50-5 Formula: C24H29FN6O5 Molecular Weight: 500.53
    ● In Stock — US warehouse, ships to EU* Item #: D413827
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    IUPAC Name
    4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one;2-hydroxypropanoic acid;hydrate
    SMILES
    CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N.O
    InChIKey
    QDPVYZNVVQQULH-UHFFFAOYSA-N
    InChI
    1S/C21H21FN6O.C3H6O3.H2O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6;/h2-6,11H,7-10H2,1Hshow more
    Synonyms
    InChI=1/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3 | BCP0726000101 | 4-Amino...
  5. Dovitinib (TKI258) Lactate
    CAS: 915769-50-5 Formula: C24H29FN6O5 Molecular Weight: 500.53
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: D426914
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    IUPAC Name
    4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one;2-hydroxypropanoic acid;hydrate
    SMILES
    CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N.O
    InChIKey
    QDPVYZNVVQQULH-UHFFFAOYSA-N
    InChI
    1S/C21H21FN6O.C3H6O3.H2O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6;/h2-6,11H,7-10H2,1Hshow more
    Synonyms
    InChI=1/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3 | BCP0726000101 | 4-Amino...
  6. ISCK03
    CAS: 945526-43-2 Formula: C19H21N3O2S Molecular Weight: 355.45
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: I427041
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    IUPAC Name
    4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
    SMILES
    CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
    InChIKey
    XQABBHBFHWHMKF-UHFFFAOYSA-N
    InChI
    1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
    Synonyms
    SCF/c-Kit Signaling Inhibitor | C77268 | HMS3229P07 | AC-35800 | t-Butylphenyl imidazolylphenyl sulfonamide | (4-t-bu...
  7. Ki20227, Inhibitor of colony stimulating factor 1 receptor;Inhibitor of kinase insert domain receptor;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase;Inhibitor of platelet derived growth factor receptor beta
    CAS: 623142-96-1 Formula: C24H24N4O5S Molecular Weight: 480.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: K425158
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    IUPAC Name
    1-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-methoxyphenyl]-3-[1-(1,3-thiazol-2-yl)ethyl]urea
    SMILES
    CC(C1=NC=CS1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)OC
    InChIKey
    SHPFDGWALWEPGS-UHFFFAOYSA-N
    InChI
    1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29)
    Synonyms
    1-(4-(6,7-Dimethoxyquinolin-4-yl)oxy-2-methoxyphenyl)-3-(1-(1,3-thiazol-2-yl)ethyl)urea | AKOS015904288 | Urea, N-(4-...
  8. MDK74978 (Multi-kinase inhibitor I)
    CAS: 778274-97-8 Formula: C20H17F3N4O3 Molecular Weight: 418.38
    ● In Stock — US warehouse, ships to EU* Item #: M412245
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    IUPAC Name
    N-(2-hydroxyethyl)-4-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
    SMILES
    C1=CC(=CC=C1C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F)C(=O)NCCO
    InChIKey
    DEGDCVFNFAOIPU-UHFFFAOYSA-N
    InChI
    1S/C20H17F3N4O3/c21-20(22,23)30-16-7-5-15(6-8-16)27-18-11-17(25-12-26-18)13-1-3-14(4-2-13)19(29)24-9-10-28/h1-8,11-12,28H,9-10H2,(H,24,29)(H,25,26,27)
    Synonyms
    Multi-kinase inhibitor 1
  9. Motesanib, Platelet-derived growth factor receptor inhibitor
    CAS: 453562-69-1 EC Number: 113-839-3 Formula: C22H23N5O Molecular Weight: 373.46
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: M424063
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    IUPAC Name
    N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
    SMILES
    CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
    InChIKey
    RAHBGWKEPAQNFF-UHFFFAOYSA-N
    InChI
    1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
    Synonyms
    N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide | NSC800801 | NSC-800801 | H...
  10. PDGFRα kinase inhibitor 2
    CAS: 404844-11-7 Formula: C24H20ClN5O Molecular Weight: 429.90
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: N335699
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    IUPAC Name
    4-(chloromethyl)-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
    SMILES
    CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CCl)NC3=NC=CC(=N3)C4=CN=CC=C4
    InChIKey
    WUGWDFMSJPJUEZ-UHFFFAOYSA-N
    InChI
    1S/C24H20ClN5O/c1-16-4-9-20(28-23(31)18-7-5-17(14-25)6-8-18)13-22(16)30-24-27-12-10-21(29-24)19-3-2-11-26-15-19/h2-13,15H,14H2,1H3,(H,28,31)(H,27,29,3show more
    Synonyms
    PD119309 | 4-(chloromethyl)-N-{4-methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}benzamide | n-(5-(4-chloromethy...
  11. Pazopanib, Inhibitor of colony stimulating factor 1 receptor;Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor;Inhibitor
    CAS: 444731-52-6 EC Number: 963-764-2 Formula: C21H23N7O2S Molecular Weight: 437.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: P424022
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    IUPAC Name
    5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
    SMILES
    CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
    InChIKey
    CUIHSIWYWATEQL-UHFFFAOYSA-N
    InChI
    1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
    Synonyms
    5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide | 5-[[4-[(2,3-d...
  12. Regorafenib (BAY-734506) Monohydrate
    CAS: 1019206-88-2 EC Number: 851-928-5 PubChem CID: 24768591 Formula: C21H15ClF4N4O3.H2O Molecular Weight: 500.83
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: R420361
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    IUPAC Name
    4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;hydrate
    SMILES
    CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O
    InChIKey
    ZOPOQLDXFHBOIH-UHFFFAOYSA-N
    InChI
    1S/C21H15ClF4N4O3.H2O/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26;/h2-10H,1H3,(H,27,31)(H2,29,show more
    Synonyms
    D10137 | AC-25914 | MFCD17170366 | 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy...
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Frequently Asked Questions

Which compounds are listed for c-Kit?
Compounds associated with c-Kit are grouped here under the Protein Tyrosine Kinase/RTK classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does c-Kit sit within Protein Tyrosine Kinase/RTK?
c-Kit is one target listing within the Protein Tyrosine Kinase/RTK classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from c-Kit?
For compounds listed under c-Kit, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for c-Kit?
Browse the parent Protein Tyrosine Kinase/RTK listing to reach targets neighbouring c-Kit, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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