c-Kit

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  1. tafetinib, Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor;Inhibitor of platelet derived growth factor receptor beta;Inhibitor of ret proto-oncogene
    CAS: 1032265-57-8 PubChem CID: 56935577
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ◐ .Made to order · 8–12 wks Item #: T614304
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    IUPAC Name
    (7Z)-N-[2-(diethylamino)ethyl]-7-(5-fluoro-2-oxo-1H-indol-3-ylidene)-2-methyl-1,4,5,6-tetrahydroindole-3-carboxamide
    SMILES
    CCN(CCNC(=O)c1c(C)[nH]c2c1CCC/C/2=C\1/C(=O)Nc2c1cc(F)cc2)CC
    InChIKey
    KGSRYTUWXUESJK-FXBPSFAMSA-N
    InChI
    1S/C24H29FN4O2/c1-4-29(5-2)12-11-26-23(30)20-14(3)27-22-16(20)7-6-8-17(22)21-18-13-15(25)9-10-19(18)28-24(21)31/h9-10,13,27H,4-8,11-12H2,1-3H3,(H,26,3show more
    Synonyms
    SIM 010603 | Q27895956 | (z)-N-(2-(diethylamino)ethyl)-2-methyl-7-(1,2-dihydro-5-fluoro-2-oxo-3h-indol-3-ylidene)-4,5...
  2. Bezuclastinib, Inhibitor of KIT proto-oncogene; receptor tyrosine kinase
    CAS: 1616385-51-3 EC Number: 885-576-9 PubChem CID: 75593308 Formula: C19H17N5O Molecular Weight: 331.37
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: B608032
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    IUPAC Name
    4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide
    SMILES
    Cc1c([nH]nc1C(=O)Nc1cnc2c(c1)cc([nH]2)c1ccccc1)C
    InChIKey
    NVSHVYGIYPBTEZ-UHFFFAOYSA-N
    InChI
    1S/C19H17N5O/c1-11-12(2)23-24-17(11)19(25)21-15-8-14-9-16(22-18(14)20-10-15)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,20,22)(H,21,25)(H,23,24)
    Synonyms
    UNII-2ROQ545LAG | CGT9486 | CGT-9486 | PLX 9486 [WHO-DD] | 2ROQ545LAG | PLX9486 | PLX-9486 | ,5-dimethyl-N-(2-phenyl-...
  3. ibcasertib, Vascular endothelial growth factor receptor inhibitor
    CAS: 1256349-48-0 PubChem CID: 49779393 Formula: C27H21N3O3 Molecular Weight: 435.47
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: I610902
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    N-(2-aminophenyl)-6-(7-methoxyquinolin-4-yl)oxynaphthalene-1-carboxamide
    SMILES
    COC1=CC2=NC=CC(=C2C=C1)OC3=CC4=C(C=C3)C(=CC=C4)C(=O)NC5=CC=CC=C5N
    InChIKey
    BRKWREZNORONDU-UHFFFAOYSA-N
    InChI
    1S/C27H21N3O3/c1-32-18-9-12-22-25(16-18)29-14-13-26(22)33-19-10-11-20-17(15-19)5-4-6-21(20)27(31)30-24-8-3-2-7-23(24)28/h2-16H,28H2,1H3,(H,30,31)
    Synonyms
    EX-A6106 | F40IRN5981 | N-(2-aminophenyl)-6-(7-methoxyquinolin-4-yl)oxynaphthalene-1-carboxamide | ibcasertib | 12563...
  4. Vimseltinib, Inhibitor of colony stimulating factor 1 receptor;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase;Inhibitor of platelet derived growth factor receptor alpha
    CAS: 1628606-05-2 Formula: C23H25N7O2 Molecular Weight: 431.49
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: V614749
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    IUPAC Name
    3-methyl-5-[6-methyl-5-[2-(1-methylpyrazol-4-yl)pyridin-4-yl]oxypyridin-2-yl]-2-(propan-2-ylamino)pyrimidin-4-one
    SMILES
    CC1=C(C=CC(=N1)C2=CN=C(N(C2=O)C)NC(C)C)OC3=CC(=NC=C3)C4=CN(N=C4)C
    InChIKey
    TVGAHWWPABTBCX-UHFFFAOYSA-N
    InChI
    1S/C23H25N7O2/c1-14(2)27-23-25-12-18(22(31)30(23)5)19-6-7-21(15(3)28-19)32-17-8-9-24-20(10-17)16-11-26-29(4)13-16/h6-14H,1-5H3,(H,25,27)
    Synonyms
    Dolkwal tartrazine | AKOS040732693 | DCC3014 | DCC-3014 | HY-136256 | Vimseltinib [USAN:INN] | compound 20 [PMID: 359...
  5. AZD3229 Tosylate
    CAS: 2248003-71-4 PubChem CID: 135367697 Formula: C31H34FN7O6S Molecular Weight: 651.71
    ◐ .Made to order · 8–12 wks Item #: A647647
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    IUPAC Name
    N-[4-[[5-fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yltriazol-1-yl)acetamide;4-methylbenzenesulfonic acid
    SMILES
    CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)C1=CN(N=N1)CC(=O)NC2=CC=C(C=C2)NC3=NC=NC4=C3C(=CC(=C4)OCCOC)F
    InChIKey
    AWHHAHZPRULJMA-UHFFFAOYSA-N
    InChI
    1S/C24H26FN7O3.C7H8O3S/c1-15(2)21-12-32(31-30-21)13-22(33)28-16-4-6-17(7-5-16)29-24-23-19(25)10-18(35-9-8-34-3)11-20(23)26-14-27-24;1-6-2-4-7(5-3-6)11show more
    Synonyms
    YPD00371 | MS-30968 | A16867 | N-[4-[[5-fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yltriaz...
  6. PLX647
    CAS: 873786-09-5 EC Number: 809-725-4 PubChem CID: 11545419 Formula: C21H17F3N4 Molecular Weight: 382.38
    ◐ .Made to order · 8–12 wks Item #: P648105
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    IUPAC Name
    5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]pyridin-2-amine
    SMILES
    C1=CC2=C(NC=C2CC3=CN=C(C=C3)NCC4=CC=C(C=C4)C(F)(F)F)N=C1
    InChIKey
    NODCQQSEMCESEC-UHFFFAOYSA-N
    InChI
    1S/C21H17F3N4/c22-21(23,24)17-6-3-14(4-7-17)11-26-19-8-5-15(12-27-19)10-16-13-28-20-18(16)2-1-9-25-20/h1-9,12-13H,10-11H2,(H,25,28)(H,26,27)
    Synonyms
    PLX647 | PLX-647 | 4hvs | AC-35285 | 5-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-(4-(trifluoromethyl)benzyl)pyridin-2...
  7. Flumatinib mesylate
    CAS: 895519-91-2 PubChem CID: 46910592 Formula: C30H33F3N8O4S Molecular Weight: 658.7
    ◐ .Made to order · 8–12 wks Item #: F648447
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    IUPAC Name
    methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide
    SMILES
    CC1=C(C=C(C=N1)NC(=O)C2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
    InChIKey
    ZSASDYCFROUKTJ-UHFFFAOYSA-N
    InChI
    1S/C29H29F3N8O.CH4O3S/c1-19-26(38-28-34-9-7-25(37-28)21-4-3-8-33-16-21)15-23(17-35-19)36-27(41)20-5-6-22(24(14-20)29(30,31)32)18-40-12-10-39(2)11-13-4show more
    Synonyms
    MFCD28053502 | DTXSID9026184 | SCHEMBL4889246 | EX-A2059 | N-(6-methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyrid...
  8. Telatinib mesylate
    CAS: 332013-26-0 Formula: C21H20ClN5O6S Molecular Weight: 505.93
    ◐ .Made to order · 8–12 wks Item #: T648659
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    Technical Identifiers
    SMILES
    O=C(C1=NC=CC(COC2=NN=C(NC3=CC=C(Cl)C=C3)C4=C2OC=C4)=C1)NC.OS(=O)(C)=O
  9. Masitinib mesylate
    CAS: 1048007-93-7 EC Number: 690-068-3 PubChem CID: 25024769 Formula: C29H34N6O4S2 Molecular Weight: 594.8
    ◐ .Made to order · 8–12 wks Item #: M649213
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    IUPAC Name
    methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
    SMILES
    CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5.CS(=O)(=O)O
    InChIKey
    TXCWBWKVIZGWEQ-UHFFFAOYSA-N
    InChI
    1S/C28H30N6OS.CH4O3S/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34;1-5(2,3)4/h3-1show more
    Synonyms
    A927557 | Masitinib Mesylate Salt; Masitinib mesilate;AB 1010 Mesylate pound>>AB1010 Mesylate pound>>AB-1010 Mesylate...
  10. Pexidartinib hydrochloride, Stem cell growth factor receptor inhibitor
    CAS: 2040295-03-0 PubChem CID: 73053710 Formula: C20H16Cl2F3N5 Molecular Weight: 454.3
    ◐ .Made to order · 8–12 wks Item #: P650884
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    IUPAC Name
    5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine;hydrochloride
    SMILES
    C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F.Cl
    InChIKey
    CJLUYLRKLUYCEK-UHFFFAOYSA-N
    InChI
    1S/C20H15ClF3N5.ClH/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24;/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,2show more
    Synonyms
    AZASETRON HYDROCHLORIDE [MART.] | Pexidartinib HCl | 5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(triflu...
  11. Tandutinib hydrochloride
    CAS: 2438900-70-8 Formula: C31H43ClN6O4 Molecular Weight: 599.16
    ◐ .Made to order · 8–12 wks Item #: T648483
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    Technical Identifiers
    SMILES
    O=C(N1CCN(C2=C(C(C=C3OCCCN4CCCCC4)=NC=N2)C=C3OC)CC1)NC5=CC=C(OC(C)C)C=C5.Cl
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Frequently Asked Questions

Which compounds are listed for c-Kit?
Compounds associated with c-Kit are grouped here under the Protein Tyrosine Kinase/RTK classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does c-Kit sit within Protein Tyrosine Kinase/RTK?
c-Kit is one target listing within the Protein Tyrosine Kinase/RTK classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from c-Kit?
For compounds listed under c-Kit, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for c-Kit?
Browse the parent Protein Tyrosine Kinase/RTK listing to reach targets neighbouring c-Kit, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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