c-Met/HGFR

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  1. SGX-523, Hepatocyte growth factor receptor inhibitor
    CAS: 1022150-57-7 PubChem CID: 24779724 Formula: C18H13N7S Molecular Weight: 359.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 2mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S420375
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    IUPAC Name
    6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline
    SMILES
    CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2
    InChIKey
    BCZUAADEACICHN-UHFFFAOYSA-N
    InChI
    1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
    Synonyms
    6-((6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)quinoline | AKOS025117577 | NCGC00263163-0...
  2. SRI 31215 TFA
    CAS: 1832686-44-8 PubChem CID: 102004307 Formula: C27H34F3N5O3 Molecular Weight: 533.59
    ● In Stock — US warehouse, ships to EU* Item #: S412134
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    IUPAC Name
    3-[3-[(1-benzylpiperidin-4-yl)methyl]-5-methyl-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide;2,2,2-trifluoroacetic acid
    SMILES
    CC1CN(C(=O)N(C1)C2=CC=CC(=C2)C(=N)N)CC3CCN(CC3)CC4=CC=CC=C4.C(=O)(C(F)(F)F)O
    InChIKey
    QJFJKJLPPLYFJA-UHFFFAOYSA-N
    InChI
    1S/C25H33N5O.C2HF3O2/c1-19-15-29(25(31)30(16-19)23-9-5-8-22(14-23)24(26)27)18-21-10-12-28(13-11-21)17-20-6-3-2-4-7-20;3-2(4,5)1(6)7/h2-9,14,19,21H,10-show more
    Synonyms
    SRI 31215
  3. SU11274, Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    CAS: 658084-23-2 EC Number: 636-258-1 PubChem CID: 9549297 Formula: C28H30CIN5O4S Molecular Weight: 568.09
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: S126117
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    IUPAC Name
    (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide
    SMILES
    CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
    InChIKey
    FPYJSJDOHRDAMT-KQWNVCNZSA-N
    InChI
    1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-1show more
    Synonyms
    BDBM50341636 | (3Z)-N-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylide...
  4. Semaxanib (SU5416), Vascular endothelial growth factor receptor inhibitor
    CAS: 194413-58-6 PubChem CID: 5329098 Formula: C15H14N2O Molecular Weight: 238.28
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: S412802
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    IUPAC Name
    (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
    SMILES
    CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
    InChIKey
    WUWDLXZGHZSWQZ-WQLSENKSSA-N
    InChI
    1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
    Synonyms
    (Z)-Semaxinib | BRN 0844684 | CAS-204005-46-9 | NCGC00094381-01 | SCHEMBL194769 | SCHEMBL19571 | SU005416 | Lopac0_00...
  5. Tivantinib (ARQ 197), Hepatocyte growth factor receptor inhibitor
    CAS: 905854-02-6 EC Number: 805-160-2 PubChem CID: 11494412 Formula: C23H19N3O2 Molecular Weight: 369.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: T426852
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    IUPAC Name
    (3R,4R)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
    SMILES
    C1CC2=C3C(=CC=C2)C(=CN3C1)C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
    InChIKey
    UCEQXRCJXIVODC-PMACEKPBSA-N
    InChI
    1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,show more
    Synonyms
    (+/-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione | (+/-)-trans-3-...
  6. X-376, Inhibitor of ALK receptor tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    CAS: 1365267-27-1 PubChem CID: 56960447 Formula: C25H25Cl2FN6O3 Molecular Weight: 547.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: X413489
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    IUPAC Name
    6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide
    SMILES
    CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CC=C(C=C3)C(=O)N4CCN(CC4)C
    InChIKey
    ONPGOSVDVDPBCY-CQSZACIVSA-N
    InChI
    1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12Hshow more
    Synonyms
    7DR7JMB8BH | NSC800968 | NSC-800968 | s6505 | X-396 | MS-30029 | X-376; X-396 | DB13104 | AKOS030528612 | BDBM5043289...
  7. X-376, Inhibitor of ALK receptor tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine kinase
    CAS: 1365267-27-1 PubChem CID: 56960447 Formula: C25H25Cl2FN6O3 Molecular Weight: 547.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: X421388
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    Technical Identifiers
    IUPAC Name
    6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide
    SMILES
    CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CC=C(C=C3)C(=O)N4CCN(CC4)C
    InChIKey
    ONPGOSVDVDPBCY-CQSZACIVSA-N
    InChI
    1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12Hshow more
    Synonyms
    7DR7JMB8BH | NSC800968 | NSC-800968 | s6505 | X-396 | MS-30029 | X-376; X-396 | DB13104 | AKOS030528612 | BDBM5043289...
  8. c-Met/RON Dual Kinase Inhibitor inhibitor
    CAS: 913376-84-8 Formula: C31H29FN4O5 Molecular Weight: 556.59
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C426891
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    IUPAC Name
    N-[3-fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide
    SMILES
    CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC)F
    InChIKey
    UYMSIPINLJNNOU-UHFFFAOYSA-N
    InChI
    1S/C31H29FN4O5/c1-19-28(30(38)36(21-8-6-5-7-9-21)35(19)18-31(2,3)39)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(40-4)11-12-23(25)26/h5-17show more
    Synonyms
    BDBM24465 | N-(3-Fluoro-4-((7-methoxyquinolin-4-yl)oxy)phenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2...
  9. 5-Chloro-3-(thiophen-2-ylmethylene)indolin-2-one
    CAS: 186611-58-5 Formula: C13H8ClNOS Molecular Weight: 261.73
    ● In Stock — US warehouse, ships to EU* Item #: W417649
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    IUPAC Name
    (3Z)-5-chloro-3-(thiophen-2-ylmethylidene)-1H-indol-2-one
    SMILES
    C1=CSC(=C1)C=C2C3=C(C=CC(=C3)Cl)NC2=O
    InChIKey
    ZYHHCVFJHNWKDY-XFFZJAGNSA-N
    InChI
    1S/C13H8ClNOS/c14-8-3-4-12-10(6-8)11(13(16)15-12)7-9-2-1-5-17-9/h1-7H,(H,15,16)/b11-7-
    Synonyms
    5-Chloro-3-(thiophen-2-ylmethylene)indolin-2-one
  10. N'-(5-fluoro-2-oxoindolin-3-ylidene)-4-hydroxybenzohydrazide
    CAS: 330572-32-2 PubChem CID: 837637 Formula: C15H10FN3O3 Molecular Weight: 299.2566032
    ● In Stock — US warehouse, ships to EU* Item #: W418155
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    IUPAC Name
    N-[(5-fluoro-2-hydroxy-1H-indol-3-yl)imino]-4-hydroxybenzamide
    SMILES
    C1=CC(=CC=C1C(=O)N=NC2=C(NC3=C2C=C(C=C3)F)O)O
    InChIKey
    NBNLEALJOLHMEO-UHFFFAOYSA-N
    InChI
    1S/C15H10FN3O3/c16-9-3-6-12-11(7-9)13(15(22)17-12)18-19-14(21)8-1-4-10(20)5-2-8/h1-7,17,20,22H
  11. Ficlatuzumab (anti-HGF), INHIBITOR of Hepatocyte growth factor inhibitor
    CAS: 1174900-84-5
    Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● In Stock — US warehouse, ships to EU* Item #: Ab170563
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    Technical Identifiers
    Associated targets
    HGF
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Reactive species
    Cynomolgus monkey, Human
    Isotype
    Human IgG1
    Host species
    Human
    Conjugation
    Unconjugated
    Synonyms
    Hepatopoietin-A | Scatter factor | SF
  12. Onartuzumab (anti-MET), Antibody of MET proto-oncogene; receptor tyrosine kinase
    CAS: 1133766-06-9
    Liquid Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● In Stock — US warehouse, ships to EU* Item #: Ab170687
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    Technical Identifiers
    Associated targets
    MET
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Reactive species
    Cynomolgus monkey, Human, Mouse
    Isotype
    Human IgG1
    Host species
    Human
    Conjugation
    Unconjugated
    Synonyms
    Onartuzumab | MetMAb | Anti-HGFR / c-Met Reference Antibody (onartuzumab) | AUTS9 antibody | c met antibody | D249 an...
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Frequently Asked Questions

What can I find under c-Met/HGFR?
This listing collects compounds associated with c-Met/HGFR within our Protein Tyrosine Kinase/RTK area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for c-Met/HGFR?
Consider the reported potency of each c-Met/HGFR compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for c-Met/HGFR compounds?
Each c-Met/HGFR product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search c-Met/HGFR compounds by activity or structure?
Yes. Filter the c-Met/HGFR listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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