CRM1

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  1. Selinexor (KPT-330)
    CAS: 1421923-86-5 Formula: C17H11F6N7O Molecular Weight: 443.3
    ◐ .Made to order · 8–12 wks Item #: S734969
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    Technical Identifiers
    IUPAC Name
    (E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide
    SMILES
    C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
    InChIKey
    DEVSOMFAQLZNKR-DAFODLJHSA-N
    InChI
    1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1+
  2. Felezonexor
    CAS: 1076235-04-5 PubChem CID: 25103750
    ◐ .Made to order · 8–12 wks Item #: F1308944
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    Technical Identifiers
    IUPAC Name
    1-[[6-chloro-5-(trifluoromethyl)pyridin-2-yl]amino]-3-(3,3-dimethylbutoxymethyl)-4-methylpyrrole-2,5-dione
    SMILES
    CC1=C(C(=O)N(C1=O)NC2=NC(=C(C=C2)C(F)(F)F)Cl)COCCC(C)(C)C
    InChIKey
    CMASLSTVVOYJQY-UHFFFAOYSA-N
    InChI
    1S/C18H21ClF3N3O3/c1-10-11(9-28-8-7-17(2,3)4)16(27)25(15(10)26)24-13-6-5-12(14(19)23-13)18(20,21)22/h5-6H,7-9H2,1-4H3,(H,23,24)
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

How is the CRM1 listing put together?
It draws on reported CRM1 annotations within Membrane Transporter/Ion Channel and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a CRM1 modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the CRM1 entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for CRM1 compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For CRM1 work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the CRM1 compound I need is not listed?
Search by CAS number or SMILES first, since analogs of CRM1 compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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