CRM1

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  1. Leptomycin A
    CAS: 87081-36-5 PubChem CID: 5384875 Formula: C32H46O6 Molecular Weight: 526.7
    ◐ .Made to order · 8–12 wks Item #: L1420277
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    Technical Identifiers
    IUPAC Name
    (2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
    SMILES
    CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C
    InChIKey
    QECBVZBMGUAZDL-DLWOFZAMSA-N
    InChI
    1S/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,1show more
  2. KPT-251
    CAS: 1388841-50-6 PubChem CID: 57519758 Formula: C14H7F6N5O Molecular Weight: 375.23
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: K1495108
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

How is the CRM1 listing put together?
It draws on reported CRM1 annotations within Membrane Transporter/Ion Channel and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a CRM1 modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the CRM1 entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for CRM1 compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For CRM1 work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the CRM1 compound I need is not listed?
Search by CAS number or SMILES first, since analogs of CRM1 compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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