DNA Alkylator/Crosslinker

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  1. PK11000
    CAS: 38275-34-2 PubChem CID: 1241459 Formula: C6H5ClN2O4S Molecular Weight: 236.63
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: P423775
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    IUPAC Name
    5-chloro-2-methylsulfonylpyrimidine-4-carboxylic acid
    SMILES
    CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl
    InChIKey
    WZUPWJVRWIVWEF-UHFFFAOYSA-N
    InChI
    1S/C6H5ClN2O4S/c1-14(12,13)6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
    Synonyms
    HY-U00447 | SY059860 | BCP30143 | CCG-266846 | EX-A3577 | AKOS000267675 | 5-chloro-2-(methylsulfonyl)-4-Pyrimidinecar...
  2. Palifosfamide, DNA cross-linking agent
    CAS: 31645-39-3 Formula: C4H11Cl2N2O2P Molecular Weight: 221.02
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: P423292
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    IUPAC Name
    bis(2-chloroethylamino)phosphinic acid
    SMILES
    C(CCl)NP(=O)(NCCCl)O
    InChIKey
    BKCJZNIZRWYHBN-UHFFFAOYSA-N
    InChI
    1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
    Synonyms
    DB05668 | IPAM | 6A4U6NN813 | Isophosphoramide mustard | Isophosphamide mustard | N,N'-Di-(2-chloroethyl)phosphorodia...
  3. Pipobroman, DNA inhibitor
    CAS: 54-91-1 EC Number: 620-535-9 PubChem CID: 4842 Formula: C10H16Br2N2O2 Molecular Weight: 356.05
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: P424683
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    IUPAC Name
    3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
    SMILES
    C1CN(CCN1C(=O)CCBr)C(=O)CCBr
    InChIKey
    NJBFOOCLYDNZJN-UHFFFAOYSA-N
    InChI
    1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2
    Synonyms
    pipobroman|54-91-1|Vercyte|Amedel|1,1'-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)|Pipobromanum|1,4-Bis(3-bromoprop...
  4. Procarbazine HCl, DNA inhibitor
    CAS: 366-70-1 EC Number: 206-678-6 Formula: C12H19N3O·HCl Molecular Weight: 257.76
    10mM in Water
    ● In Stock — US warehouse, ships to EU* Item #: P423643
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    IUPAC Name
    4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride
    SMILES
    CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
    InChIKey
    DERJYEZSLHIUKF-UHFFFAOYSA-N
    InChI
    1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
    Synonyms
    Procarbazine hydrochloride|366-70-1|PROCARBAZINE HCl|Matulane|Nathulane|Natunalar|MIH hydrochloride|PCB hydrochloride...
  5. Semustine
    CAS: 13909-09-6 EC Number: 634-275-9 PubChem CID: 5198 Formula: C10H18ClN3O2 Molecular Weight: 247.72
    ● In Stock — US warehouse, ships to EU* Item #: S340465
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    IUPAC Name
    1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
    SMILES
    CC1CCC(CC1)NC(=O)N(CCCl)N=O
    InChIKey
    FVLVBPDQNARYJU-UHFFFAOYSA-N
    InChI
    1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)
    Synonyms
    KBioSS_001815 | Lomustine, methyl | Methyl-CCNU [Chloroethyl nitrosoureas] | Q1230937 | NSC135091 | NSC-135091 | Semu...
  6. Treosulfan
    CAS: 299-75-2 EC Number: 206-081-0 PubChem CID: 9882105 Formula: C6H14O8S2 Molecular Weight: 278.30
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: T423077
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    IUPAC Name
    [(2S,3S)-2,3-dihydroxy-4-methylsulfonyloxybutyl] methanesulfonate
    SMILES
    CS(=O)(=O)OCC(C(COS(=O)(=O)C)O)O
    InChIKey
    YCPOZVAOBBQLRI-WDSKDSINSA-N
    InChI
    1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1
    Synonyms
    3-isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3S,4aR,6S,8aR)- | TREOSULFAN [INN] | TREOSULFAN [WHO-...
  7. Treosulfan
    CAS: 299-75-2 PubChem CID: 9882105 Formula: C6H14O8S2 Molecular Weight: 278.30
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: T413686
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    Technical Identifiers
    IUPAC Name
    [(2S,3S)-2,3-dihydroxy-4-methylsulfonyloxybutyl] methanesulfonate
    SMILES
    CS(=O)(=O)OCC(C(COS(=O)(=O)C)O)O
    InChIKey
    YCPOZVAOBBQLRI-WDSKDSINSA-N
    InChI
    1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1
    Synonyms
    3-isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3S,4aR,6S,8aR)- | TREOSULFAN [INN] | TREOSULFAN [WHO-...
  8. Tri(1-aziridinyl)phosphine sulfide, DNA inhibitor
    CAS: 52-24-4 EC Number: 200-135-7 PubChem CID: 5453 Formula: C6H12N3PS Molecular Weight: 189.22
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: T424475
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    IUPAC Name
    tris(aziridin-1-yl)-sulfanylidene-λ5-phosphane
    SMILES
    C1CN1P(=S)(N2CC2)N3CC3
    InChIKey
    FOCVUCIESVLUNU-UHFFFAOYSA-N
    InChI
    1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
    Synonyms
    thiotepa|THIO-TEPA|52-24-4|Triethylenethiophosphoramide|Thioplex|Thiophosphamide|Tiofosfamid|Tiofosyl|Thiofozil|Tespa...
  9. VH 032 amide-PEG1-acid
    CAS: 2172820-07-2 PubChem CID: 134184040 Formula: C28H38N4O7S Molecular Weight: 574.69
    ◐ .Made to order · 8–12 wks Item #: V287984
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    IUPAC Name
    3-[3-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxoproshow more
    SMILES
    CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCC(=O)O)O
    InChIKey
    HVPZHRHEHKZOOJ-TYBLODHISA-N
    InChI
    1S/C28H38N4O7S/c1-17-24(40-16-30-17)19-7-5-18(6-8-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)9-11-39-12-10-23(35)36/h5-8,16,20-21,show more
    Synonyms
    3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan...
  10. Mitomycin C
    CAS: 50-07-7 EC Number: 200-008-6 Formula: C15H18N4O5 Molecular Weight: 334.33
    Solid ≥98% from Streptomyces caespitosus
    ● In Stock — US warehouse, ships to EU* Item #: M476633
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    IUPAC Name
    [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
    SMILES
    CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
    InChIKey
    NWIBSHFKIJFRCO-WUDYKRTCSA-N
    InChI
    1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
    Synonyms
    KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-metho...
  11. Nitrilotri(methylphosphonic acid)
    CAS: 6419-19-8 EC Number: 229-146-5 Formula: C3H12NO9P3 Molecular Weight: 299.05
    ● In Stock — Germany Item #: N433216
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    IUPAC Name
    [bis(phosphonomethyl)amino]methylphosphonic acid
    SMILES
    C(N(CP(=O)(O)O)CP(=O)(O)O)P(=O)(O)O
    InChIKey
    YDONNITUKPKTIG-UHFFFAOYSA-N
    InChI
    1S/C3H12NO9P3/c5-14(6,7)1-4(2-15(8,9)10)3-16(11,12)13/h1-3H2,(H2,5,6,7)(H2,8,9,10)(H2,11,12,13)
    Synonyms
    Tris(phosphonomethyl)amine | ATMP
  12. Busulfan
    CAS: 55-98-1 EC Number: 200-250-2 Formula: C6H14O6S2 Molecular Weight: 246.3
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In Stock — US warehouse, ships to EU* Item #: B573218
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    Technical Identifiers
    IUPAC Name
    4-methylsulfonyloxybutyl methanesulfonate
    SMILES
    CS(=O)(=O)OCCCCOS(=O)(=O)C
    InChIKey
    COVZYZSDYWQREU-UHFFFAOYSA-N
    InChI
    1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
    Synonyms
    DTXSID3020910 | 2041 C. B. | BUSULFAN [VANDF] | Mielosan | Tetramethylene {bis[methanesulfonate]} | TETRAMETHYLENE DI...
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Frequently Asked Questions

Which compounds are listed for DNA Alkylator/Crosslinker?
Compounds associated with DNA Alkylator/Crosslinker are grouped here under the Cell Cycle/DNA Damage classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does DNA Alkylator/Crosslinker sit within Cell Cycle/DNA Damage?
DNA Alkylator/Crosslinker is one target listing within the Cell Cycle/DNA Damage classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from DNA Alkylator/Crosslinker?
For compounds listed under DNA Alkylator/Crosslinker, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for DNA Alkylator/Crosslinker?
Browse the parent Cell Cycle/DNA Damage listing to reach targets neighbouring DNA Alkylator/Crosslinker, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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