DNA Alkylator/Crosslinker

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  1. CB 1954
    CAS: 21919-05-1 Formula: C9H8N4O5 Molecular Weight: 252.18
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C422631
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    IUPAC Name
    5-(aziridin-1-yl)-2,4-dinitrobenzamide
    SMILES
    C1CN1C2=C(C=C(C(=C2)C(=O)N)[N+](=O)[O-])[N+](=O)[O-]
    InChIKey
    WOCXQMCIOTUMJV-UHFFFAOYSA-N
    InChI
    1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14)
    Synonyms
    EU-0100200 | HY-13543 | Lopac0_000200 | 2,4-Dinitro-5-ethyleneiminobenzamide | CB1954(Tretazicar) | LP00200 | BDBM500...
  2. CB1954
    CAS: 21919-05-1 Formula: C9H8N4O5 Molecular Weight: 252.18
    Solid ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C413845
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    IUPAC Name
    5-(aziridin-1-yl)-2,4-dinitrobenzamide
    SMILES
    C1CN1C2=C(C=C(C(=C2)C(=O)N)[N+](=O)[O-])[N+](=O)[O-]
    InChIKey
    WOCXQMCIOTUMJV-UHFFFAOYSA-N
    InChI
    1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14)
    Synonyms
    EU-0100200 | HY-13543 | Lopac0_000200 | 2,4-Dinitro-5-ethyleneiminobenzamide | CB1954(Tretazicar) | LP00200 | BDBM500...
  3. Carboplatin
    CAS: 41575-94-4 EC Number: 255-446-0 Formula: C6H12N2O4Pt Molecular Weight: 371.25
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in Water
    ● In Stock — US warehouse, ships to EU* Item #: C423884
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    IUPAC Name
    azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
    SMILES
    C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
    InChIKey
    VSRXQHXAPYXROS-UHFFFAOYSA-N
    InChI
    1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2
    Synonyms
    41575-94-4|Carboplatin|Paraplatin|Cbdca|Carboplatinum|MFCD00070464|NSC-241240|cis-(1,1-Cyclobutanedicarboxylato)diamm...
  4. Carboxyphosphamide
    CAS: 22788-18-7 Formula: C7H15Cl2N2O4P Molecular Weight: 293.08
    Solid ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: C333554
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    IUPAC Name
    3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid
    SMILES
    C(COP(=O)(N)N(CCCl)CCCl)C(=O)O
    InChIKey
    QLAKAJLYYGOZQL-UHFFFAOYSA-N
    InChI
    1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(10,14)15-6-1-7(12)13/h1-6H2,(H2,10,14)(H,12,13)
    Synonyms
    3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid | Carboxyphosphamide | Propanoic acid, 3-((amino(bis(2...
  5. Carmustine, RNA inhibitor
    CAS: 154-93-8 EC Number: 205-838-2 Formula: C5H9Cl2N3O2 Molecular Weight: 214.05
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C421842
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    IUPAC Name
    1,3-bis(2-chloroethyl)-1-nitrosourea
    SMILES
    C(CCl)NC(=O)N(CCCl)N=O
    InChIKey
    DLGOEMSEDOSKAD-UHFFFAOYSA-N
    InChI
    1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
    Synonyms
    carmustine|154-93-8|1,3-Bis(2-chloroethyl)-1-nitrosourea|BCNU|Carmubris|Carmustin|Gliadel|Nitrumon|BiCNU|Becenun|Bisc...
  6. Chlorambucil, DNA inhibitor
    CAS: 305-03-3 EC Number: 206-162-0 Formula: C14H19Cl2NO2 Molecular Weight: 304.21
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C423161
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    IUPAC Name
    4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
    SMILES
    C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
    InChIKey
    JCKYGMPEJWAADB-UHFFFAOYSA-N
    InChI
    1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
    Synonyms
    chlorambucil|305-03-3|Ambochlorin|Leukeran|Chloroambucil|Chloraminophen|Chlorbutin|Chloraminophene|Chlorobutine|Amboc...
  7. Cyclophosphamide monohydrate, DNA inhibitor
    CAS: 6055-19-2 EC Number: 640-398-9 PubChem CID: 22420 Formula: C7H15Cl2N2O2P·H2O Molecular Weight: 279.1
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C425018
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    IUPAC Name
    N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine;hydrate
    SMILES
    C1CNP(=O)(OC1)N(CCCl)CCCl.O
    InChIKey
    PWOQRKCAHTVFLB-UHFFFAOYSA-N
    InChI
    1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
    Synonyms
    2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate | CCG-40013 | Cyclophosphamide hydrate | Cyclophos...
  8. Iodoacetamide, Activator of TRPA1
    CAS: 144-48-9 EC Number: 205-630-1 Formula: C2H4INO Molecular Weight: 184.96
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: I421630
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    IUPAC Name
    2-iodoacetamide
    SMILES
    C(C(=O)N)I
    InChIKey
    PGLTVOMIXTUURA-UHFFFAOYSA-N
    InChI
    1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
    Synonyms
    A808220 | Iodoacetamide, >=98.0% (AT), purum | Iodoacetamide, Single use vial of 56 mg | SCHEMBL20371 | 1219802-64-8 ...
  9. Lurbinectedin (PM01183), DNA negative modulator
    CAS: 497871-47-3 PubChem CID: 57327016 Formula: C41H44N4O10S Molecular Weight: 784.87
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: L414424
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    IUPAC Name
    [(1R,2R,3R,11S,12S,14R,26R)-5,12-dihydroxy-6,6'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,show more
    SMILES
    CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)O)COC(=O)C8(CS5)C9=C(CCN8)C2=C(N9)C=CC(=C2)OC)OCO7)C)OC(=O)C)C(=C1OC)O
    InChIKey
    YDDMIZRDDREKEP-HWTBNCOESA-N
    InChI
    1S/C41H44N4O10S/c1-17-11-20-12-25-39(48)45-26-14-52-40(49)41(38-22(9-10-42-41)23-13-21(50-5)7-8-24(23)43-38)15-56-37(31(45)30(44(25)4)27(20)32(47)33(1show more
    Synonyms
    T0321 | DTXCID60120556 | s9603 | LURBINECTEDIN [MI] | Tryptamicidin | PM01183;PM-1183;LY-01017;ryptamicidin | s6294 |...
  10. Mitomycin C
    CAS: 50-07-7 EC Number: 200-008-6 Formula: C15H18N4O5 Molecular Weight: 334.33
    Solid ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: D419552
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    IUPAC Name
    [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
    SMILES
    CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
    InChIKey
    NWIBSHFKIJFRCO-WUDYKRTCSA-N
    InChI
    1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
    Synonyms
    mitomycin C|Mitomycin|50-07-7|Ametycine|Mutamycin|Mitomycin-C|Mitocin-C|Ametycin|Mytozytrex|Mitomycinum|Mytomycin|Mit...
  11. N-Butyl-N-(4-hydroxybutyl)nitrosamine
    CAS: 3817-11-6 EC Number: 625-015-5 Formula: C8H18N2O2 Molecular Weight: 174.24
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: N427234
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    IUPAC Name
    N-butyl-N-(4-hydroxybutyl)nitrous amide
    SMILES
    CCCCN(CCCCO)N=O
    InChIKey
    DIKPQFXYECAYPC-UHFFFAOYSA-N
    InChI
    1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3
    Synonyms
    N-Butyl-N-(4-hydroxybutyl)nitrosamine|3817-11-6|N-butyl-N-(4-hydroxybutyl)nitrous amide|1-Butanol, 4-(butylnitrosoami...
  12. Nimustine Hydrochloride
    CAS: 55661-38-6 EC Number: 678-313-2 Formula: C9H13ClN6O2·HCl Molecular Weight: 309.15
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: N424737
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    IUPAC Name
    3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea;hydrochloride
    SMILES
    CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O.Cl
    InChIKey
    KPMKNHGAPDCYLP-UHFFFAOYSA-N
    InChI
    1S/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10;/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);1H
    Synonyms
    BN164659 | Nidran (TN) | N'-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitrosourea HCl | Nidran hyd...
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Frequently Asked Questions

Which compounds are listed for DNA Alkylator/Crosslinker?
Compounds associated with DNA Alkylator/Crosslinker are grouped here under the Cell Cycle/DNA Damage classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does DNA Alkylator/Crosslinker sit within Cell Cycle/DNA Damage?
DNA Alkylator/Crosslinker is one target listing within the Cell Cycle/DNA Damage classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from DNA Alkylator/Crosslinker?
For compounds listed under DNA Alkylator/Crosslinker, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for DNA Alkylator/Crosslinker?
Browse the parent Cell Cycle/DNA Damage listing to reach targets neighbouring DNA Alkylator/Crosslinker, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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