E1/E2/E3 Enzyme

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  1. C25-140
    CAS: 1358099-18-9 Formula: C26H31N7O Molecular Weight: 457.57
    ● In Stock — US warehouse, ships to EU* Item #: C413582
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    IUPAC Name
    1-(4-benzylpiperidin-1-yl)-3-[3,5-dimethyl-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)pyrazol-4-yl]propan-1-one
    SMILES
    CC1=C(C(=NN1C2=NN3C(=NN=C3C=C2)C)C)CCC(=O)N4CCC(CC4)CC5=CC=CC=C5
    InChIKey
    HFKVRXVHZGBRKF-UHFFFAOYSA-N
    InChI
    1S/C26H31N7O/c1-18-23(19(2)32(29-18)25-11-10-24-28-27-20(3)33(24)30-25)9-12-26(34)31-15-13-22(14-16-31)17-21-7-5-4-6-8-21/h4-8,10-11,22H,9,12-17H2,1-3show more
    Synonyms
    1-Propanone,3-[3,5-dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-p...
  2. CC-92480
    CAS: 2259648-80-9 Formula: C32H30FN5O4 Molecular Weight: 567.61
    ● In Stock — US warehouse, ships to EU* Item #: C414305
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    IUPAC Name
    4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile
    SMILES
    C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCN(CC5)C6=C(C=C(C=C6)C#N)F
    InChIKey
    YTINZZFBHWSAGL-NDEPHWFRSA-N
    InChI
    1S/C32H30FN5O4/c33-26-16-23(17-34)8-9-27(26)37-14-12-36(13-15-37)18-21-4-6-22(7-5-21)20-42-29-3-1-2-24-25(29)19-38(32(24)41)28-10-11-30(39)35-31(28)40show more
    Synonyms
    BENZONITRILE, 4-(4-((4-(((2-((3S)-2,6-DIOXO-3-PIPERIDINYL)-2,3-DIHYDRO-1-OXO-1H-ISOINDOL-4-YL)OXY)METHYL)PHENYL)METHY...
  3. CC-92480
    CAS: 2259648-80-9 Formula: C32H30FN5O4 Molecular Weight: 567.61
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C422712
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    Technical Identifiers
    IUPAC Name
    4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile
    SMILES
    C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCN(CC5)C6=C(C=C(C=C6)C#N)F
    InChIKey
    YTINZZFBHWSAGL-NDEPHWFRSA-N
    InChI
    1S/C32H30FN5O4/c33-26-16-23(17-34)8-9-27(26)37-14-12-36(13-15-37)18-21-4-6-22(7-5-21)20-42-29-3-1-2-24-25(29)19-38(32(24)41)28-10-11-30(39)35-31(28)40show more
    Synonyms
    BENZONITRILE, 4-(4-((4-(((2-((3S)-2,6-DIOXO-3-PIPERIDINYL)-2,3-DIHYDRO-1-OXO-1H-ISOINDOL-4-YL)OXY)METHYL)PHENYL)METHY...
  4. CC 0651
    CAS: 1319207-44-7 Formula: C20H21Cl2NO6 Molecular Weight: 442.29
    ● In Stock — US warehouse, ships to EU* Item #: C287811
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    IUPAC Name
    (2R,3S,4S)-5-[4-(3,5-dichlorophenyl)phenyl]-2,3-dihydroxy-4-[(2-methoxyacetyl)amino]pentanoic acid
    SMILES
    COCC(=O)NC(CC1=CC=C(C=C1)C2=CC(=CC(=C2)Cl)Cl)C(C(C(=O)O)O)O
    InChIKey
    NTCBTNCWNRCBGX-YTQUADARSA-N
    InChI
    1S/C20H21Cl2NO6/c1-29-10-17(24)23-16(18(25)19(26)20(27)28)6-11-2-4-12(5-3-11)13-7-14(21)9-15(22)8-13/h2-5,7-9,16,18-19,25-26H,6,10H2,1H3,(H,23,24)(H,2show more
    Synonyms
    (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
  5. COH000
    CAS: 1534358-79-6 Formula: C25H25NO5 Molecular Weight: 419.47
    ≥96% mixture of isomers
    ● In Stock — US warehouse, ships to EU* Item #: C412315
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    IUPAC Name
    dimethyl (1R,4S)-1-[(1R)-1-anilino-2-(4-methylphenyl)ethyl]-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate
    SMILES
    CC1=CC=C(C=C1)CC(C23C=CC(O2)C(=C3C(=O)OC)C(=O)OC)NC4=CC=CC=C4
    InChIKey
    UFPINDDCTUCUSA-DFIYOIEZSA-N
    InChI
    1S/C25H25NO5/c1-16-9-11-17(12-10-16)15-20(26-18-7-5-4-6-8-18)25-14-13-19(31-25)21(23(27)29-2)22(25)24(28)30-3/h4-14,19-20,26H,15H2,1-3H3/t19-,20+,25-/show more
    Synonyms
    7-​Oxabicyclo[2.2.1]​hepta-​2,​5-​diene-​2,​3-​dicarboxylic acid,1-​[(1R)​-​2-​(4-​methylphenyl)​-​1-​(phenylamino)​e...
  6. DKM 2-93
    CAS: 65836-72-8 Formula: C11H14ClNO3 Molecular Weight: 243.69
    ● In Stock — US warehouse, ships to EU* Item #: D413345
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    Technical Identifiers
    IUPAC Name
    2-chloro-N-[(3,4-dimethoxyphenyl)methyl]acetamide
    SMILES
    COC1=C(C=C(C=C1)CNC(=O)CCl)OC
    InChIKey
    CETPWRGZGWGPSV-UHFFFAOYSA-N
    InChI
    1S/C11H14ClNO3/c1-15-9-4-3-8(5-10(9)16-2)7-13-11(14)6-12/h3-5H,6-7H2,1-2H3,(H,13,14)
    Synonyms
    DTXSID40216022 | SCHEMBL20456221 | 2-chloro-N-(3,4-dimethoxybenzyl)acetamide | 2-Chloro-N-(3,4-dimethoxy-benzyl)-acet...
  7. DKM 2-93
    CAS: 65836-72-8 Formula: C11H14ClNO3 Molecular Weight: 243.69
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: D425322
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    Technical Identifiers
    IUPAC Name
    2-chloro-N-[(3,4-dimethoxyphenyl)methyl]acetamide
    SMILES
    COC1=C(C=C(C=C1)CNC(=O)CCl)OC
    InChIKey
    CETPWRGZGWGPSV-UHFFFAOYSA-N
    InChI
    1S/C11H14ClNO3/c1-15-9-4-3-8(5-10(9)16-2)7-13-11(14)6-12/h3-5H,6-7H2,1-2H3,(H,13,14)
    Synonyms
    DTXSID40216022 | SCHEMBL20456221 | 2-chloro-N-(3,4-dimethoxybenzyl)acetamide | 2-Chloro-N-(3,4-dimethoxy-benzyl)-acet...
  8. Siremadlin, Tumour suppressor p53/oncoprotein Mdm2 inhibitor
    CAS: 1448867-41-1 Formula: C26H24Cl2N6O4 Molecular Weight: 555.41
    ● In Stock — US warehouse, ships to EU* Item #: H414082
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    Technical Identifiers
    IUPAC Name
    (4S)-5-(5-chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one
    SMILES
    CC(C)N1C2=C(C(=O)N(C2C3=CC=C(C=C3)Cl)C4=CC(=CN(C4=O)C)Cl)N=C1C5=CN=C(N=C5OC)OC
    InChIKey
    AGBSXNCBIWWLHD-FQEVSTJZSA-N
    InChI
    1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18)35)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-show more
    Synonyms
    HY-18658 | WHO 10869 | (Benzyloxycarbonyl-methyl-amino)-acetic acid | (4~{S})-5-(5-chloranyl-1-methyl-2-oxidanylidene...
  9. JNJ-26854165 (Serdemetan)
    CAS: 881202-45-5 PubChem CID: 11609586 Formula: C21H20N4 Molecular Weight: 328.42
    ● In Stock — US warehouse, ships to EU* Item #: S126246
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    IUPAC Name
    1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
    SMILES
    C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
    InChIKey
    CEGSUKYESLWKJP-UHFFFAOYSA-N
    InChI
    1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
    Synonyms
    CCG-264846 | AS-56263 | NCGC00263171-01 | 2-(Furan-2-yl)thiazolidine-4-carboxylicacid | JNJ-26854165 (Serdemetan) | F...
  10. MI-773 (SAR405838)
    CAS: 1303607-60-4 Formula: C29H34Cl2FN3O3 Molecular Weight: 562.5
    ◐ .Made to order · 8–12 wks Item #: M413803
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    Technical Identifiers
    IUPAC Name
    (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboshow more
    SMILES
    CC(C)(C)CC1C2(C(C(N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
    InChIKey
    IDKAKZRYYDCJDU-AEPXTFJPSA-N
    InChI
    1S/C29H34Cl2FN3O3/c1-28(2,3)14-22-29(19-12-7-15(30)13-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-16-8-10-17(36)11-9-16/h4-7,12-13,show more
    Synonyms
    (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-...
  11. MI-773 (SAR405838)
    CAS: 1303607-60-4 Formula: C29H34Cl2FN3O3 Molecular Weight: 562.5
    10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: M421181
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    Technical Identifiers
    IUPAC Name
    (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboshow more
    SMILES
    CC(C)(C)CC1C2(C(C(N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
    InChIKey
    IDKAKZRYYDCJDU-AEPXTFJPSA-N
    InChI
    1S/C29H34Cl2FN3O3/c1-28(2,3)14-22-29(19-12-7-15(30)13-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-16-8-10-17(36)11-9-16/h4-7,12-13,show more
    Synonyms
    SAR405838|1303607-60-4|MI-77301|SAR-405838|MI-773 (SAR405838)|8570LZ3RCA|CHEMBL2381408|(2'S,3R,4'S,5'R)-6-Chloro-4'-(...
  12. ML792
    CAS: 1644342-14-2 PubChem CID: 86566743 Formula: C21H23BrN6O5S Molecular Weight: 551.41
    ● In Stock — US warehouse, ships to EU* Item #: M414120
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    IUPAC Name
    [(1R,2S,4R)-4-[[5-[1-[(3-bromophenyl)methyl]pyrazole-3-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate
    SMILES
    C1C(CC(C1COS(=O)(=O)N)O)NC2=NC=NC=C2C(=O)C3=NN(C=C3)CC4=CC(=CC=C4)Br
    InChIKey
    PZCKLTWSXFDLLP-OGWOLHLISA-N
    InChI
    1S/C21H23BrN6O5S/c22-15-3-1-2-13(6-15)10-28-5-4-18(27-28)20(30)17-9-24-12-25-21(17)26-16-7-14(19(29)8-16)11-33-34(23,31)32/h1-6,9,12,14,16,19,29H,7-8,show more
    Synonyms
    Sulfamic acid,[(1R,​2S,​4R)​-​4-​[[5-​[[1-​[(3-​bromophenyl)​methyl]​-​1H-​pyrazol-​3-​yl]​carbonyl]​-​4-​pyrimidinyl]�...
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Frequently Asked Questions

What can I find under E1/E2/E3 Enzyme?
This listing collects compounds associated with E1/E2/E3 Enzyme within our Metabolic Enzyme/Protease area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for E1/E2/E3 Enzyme?
Consider the reported potency of each E1/E2/E3 Enzyme compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for E1/E2/E3 Enzyme compounds?
Each E1/E2/E3 Enzyme product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search E1/E2/E3 Enzyme compounds by activity or structure?
Yes. Filter the E1/E2/E3 Enzyme listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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