E1/E2/E3 Enzyme

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  1. RO8994
    CAS: 1309684-94-3 PubChem CID: 53238217 Formula: C31H31Cl2FN4O4 Molecular Weight: 613.51
    ● In Stock — US warehouse, ships to EU* Item #: R412215
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    IUPAC Name
    (2'R,3R,3'S,5'S)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-show more
    SMILES
    CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
    InChIKey
    MURAVORBGFDSMA-ISKXDESKSA-N
    InChI
    1S/C31H31Cl2FN4O4/c1-30(2,3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4show more
  2. RO8994
    CAS: 1309684-94-3 PubChem CID: 53238217 Formula: C31H31Cl2FN4O4 Molecular Weight: 613.51
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: R421203
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    Technical Identifiers
    IUPAC Name
    (2'R,3R,3'S,5'S)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-show more
    SMILES
    CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
    InChIKey
    MURAVORBGFDSMA-ISKXDESKSA-N
    InChI
    1S/C31H31Cl2FN4O4/c1-30(2,3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4show more
  3. SKPin C1
    CAS: 432001-69-9 PubChem CID: 5733396 Formula: C18H13BrN2O4S2 Molecular Weight: 465.34
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S423949
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    IUPAC Name
    2-[4-bromo-2-[(Z)-[4-oxo-3-(pyridin-3-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]acetic acid
    SMILES
    C1=CC(=CN=C1)CN2C(=O)C(=CC3=C(C=CC(=C3)Br)OCC(=O)O)SC2=S
    InChIKey
    IYCJJVVXEHZJHE-CHHVJCJISA-N
    InChI
    1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-
    Synonyms
    2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
  4. SZL P1-41
    CAS: 222716-34-9 EC Number: 995-966-1 PubChem CID: 1286902 Formula: C24H24N2O3S Molecular Weight: 420.52
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: S422674
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    IUPAC Name
    3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-(piperidin-1-ylmethyl)chromen-4-one
    SMILES
    CCC1=CC2=C(C(=C1O)CN3CCCCC3)OC=C(C2=O)C4=NC5=CC=CC=C5S4
    InChIKey
    JKIXLEKBXHMXTN-UHFFFAOYSA-N
    InChI
    1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,show more
    Synonyms
    3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
  5. Subasumstat (TAK-981)
    CAS: 1858276-04-6 PubChem CID: 118628567 Formula: C25H28ClN5O5S2 Molecular Weight: 578.10
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: S414205
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    IUPAC Name
    [(1R,2S,4R)-4-[[5-[4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methylshow more
    SMILES
    CC1=C(C=C(S1)C(=O)C2=CN=CN=C2NC3CC(C(C3)O)COS(=O)(=O)N)C4C5=C(CCN4)C=CC(=C5)Cl
    InChIKey
    LXRZVMYMQHNYJB-UNXOBOICSA-N
    InChI
    1S/C25H28ClN5O5S2/c1-13-18(23-19-7-16(26)3-2-14(19)4-5-29-23)9-22(37-13)24(33)20-10-28-12-30-25(20)31-17-6-15(21(32)8-17)11-36-38(27,34)35/h2-3,7,9-10show more
    Synonyms
    [(1R,2S,4R)-4-{[5-({4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-2- thienyl}carbonyl)pyrimidin-4-yl]...
  6. TAK-243 (MLN7243)
    CAS: 1450833-55-2 PubChem CID: 71715374 Formula: C19H20F3N5O5S2 Molecular Weight: 519.52
    ● In Stock — US warehouse, ships to EU* Item #: T413978
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    IUPAC Name
    [(1R,2R,3S,4R)-2,3-dihydroxy-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate
    SMILES
    C1C(C(C(C1NC2=CC=NC3=CC(=NN23)C4=CC(=CC=C4)SC(F)(F)F)O)O)COS(=O)(=O)N
    InChIKey
    KJDAGXLMHXUAGV-DGWLBADLSA-N
    InChI
    1S/C19H20F3N5O5S2/c20-19(21,22)33-12-3-1-2-10(6-12)13-8-16-24-5-4-15(27(16)26-13)25-14-7-11(17(28)18(14)29)9-32-34(23,30)31/h1-6,8,11,14,17-18,25,28-2show more
    Synonyms
    BDBM329836 | Z2327515161 | AS-17418 | HY-100487 | TAK-243 (MLN7243) | SCHEMBL15191794 | A930232 | AKOS037648830 | MLN...
  7. WAY-226055
    CAS: 381717-91-5 PubChem CID: 6049382 Formula: C23H20ClN3O3 Molecular Weight: 421.88
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: W423766
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    IUPAC Name
    (4E)-5-(4-chlorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-imidazol-1-ylpropyl)pyrrolidine-2,3-dione
    SMILES
    C1=CC=C(C=C1)C(=C2C(N(C(=O)C2=O)CCCN3C=CN=C3)C4=CC=C(C=C4)Cl)O
    InChIKey
    JBSITHXZPKMWGY-XUTLUUPISA-N
    InChI
    1S/C23H20ClN3O3/c24-18-9-7-16(8-10-18)20-19(21(28)17-5-2-1-3-6-17)22(29)23(30)27(20)13-4-12-26-14-11-25-15-26/h1-3,5-11,14-15,20,28H,4,12-13H2/b21-19+
  8. WAY-300374
    CAS: 350678-63-6 PubChem CID: 5819340 Formula: C23H20FN3O3 Molecular Weight: 405.42
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: W423559
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    Technical Identifiers
    IUPAC Name
    (4E)-5-(4-fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-imidazol-1-ylpropyl)pyrrolidine-2,3-dione
    SMILES
    C1=CC=C(C=C1)C(=C2C(N(C(=O)C2=O)CCCN3C=CN=C3)C4=CC=C(C=C4)F)O
    InChIKey
    WZHIJKGQYGXRHB-XUTLUUPISA-N
    InChI
    1S/C23H20FN3O3/c24-18-9-7-16(8-10-18)20-19(21(28)17-5-2-1-3-6-17)22(29)23(30)27(20)13-4-12-26-14-11-25-15-26/h1-3,5-11,14-15,20,28H,4,12-13H2/b21-19+
  9. YH 239-EE
    CAS: 1364488-67-4 PubChem CID: 56943013 Formula: C25H27Cl2N3O4 Molecular Weight: 504.41
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: Y421383
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    IUPAC Name
    ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
    SMILES
    CCOC(=O)C1=C(C2=C(N1)C=C(C=C2)Cl)C(C(=O)NC(C)(C)C)N(CC3=CC=C(C=C3)Cl)C=O
    InChIKey
    OTUBDDRFPQLPKD-UHFFFAOYSA-N
    InChI
    1S/C25H27Cl2N3O4/c1-5-34-24(33)21-20(18-11-10-17(27)12-19(18)28-21)22(23(32)29-25(2,3)4)30(14-31)13-15-6-8-16(26)9-7-15/h6-12,14,22,28H,5,13H2,1-4H3,(show more
    Synonyms
    Ethyl 3-[2-(tert-butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
  10. 1-(3-(1H-Imidazol-1-yl)propyl)-5-(4-chlorophenyl)-4-(hydroxy(phenyl)methylene)pyrrolidine-2,3-dione
    CAS: 381717-91-5 PubChem CID: 6049382 Formula: C23H20ClN3O3 Molecular Weight: 421.88
    ● In Stock — US warehouse, ships to EU* Item #: W416745
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    Technical Identifiers
    IUPAC Name
    (4E)-5-(4-chlorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-imidazol-1-ylpropyl)pyrrolidine-2,3-dione
    SMILES
    C1=CC=C(C=C1)C(=C2C(N(C(=O)C2=O)CCCN3C=CN=C3)C4=CC=C(C=C4)Cl)O
    InChIKey
    JBSITHXZPKMWGY-XUTLUUPISA-N
    InChI
    1S/C23H20ClN3O3/c24-18-9-7-16(8-10-18)20-19(21(28)17-5-2-1-3-6-17)22(29)23(30)27(20)13-4-12-26-14-11-25-15-26/h1-3,5-11,14-15,20,28H,4,12-13H2/b21-19+
  11. WAY-300374
    CAS: 350678-63-6 PubChem CID: 5819340 Formula: C23H20FN3O3 Molecular Weight: 405.42
    ● In Stock — US warehouse, ships to EU* Item #: W416827
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    Technical Identifiers
    IUPAC Name
    (4E)-5-(4-fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-imidazol-1-ylpropyl)pyrrolidine-2,3-dione
    SMILES
    C1=CC=C(C=C1)C(=C2C(N(C(=O)C2=O)CCCN3C=CN=C3)C4=CC=C(C=C4)F)O
    InChIKey
    WZHIJKGQYGXRHB-XUTLUUPISA-N
    InChI
    1S/C23H20FN3O3/c24-18-9-7-16(8-10-18)20-19(21(28)17-5-2-1-3-6-17)22(29)23(30)27(20)13-4-12-26-14-11-25-15-26/h1-3,5-11,14-15,20,28H,4,12-13H2/b21-19+
    Synonyms
    1-(3-(1H-imidazol-1-yl)propyl)-4-benzoyl-5-(4-fluorophenyl)-3-hydroxy-1H-pyrrol-2(5H)-one
  12. EN450, ubiquitin conjugating enzyme E2 D1
    CAS: 793719-01-4 PubChem CID: 4877041 Formula: C11H13ClN2O3S Molecular Weight: 288.75
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: E610116
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    IUPAC Name
    N-[2-chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide
    SMILES
    CN(C)S(=O)(=O)C1=CC=C(Cl)C(NC(=O)C=C)=C1
    InChIKey
    OXFXDOLAQBMOPH-UHFFFAOYSA-N
    InChI
    1S/C11H13ClN2O3S/c1-4-11(15)13-10-7-8(5-6-9(10)12)18(16,17)14(2)3/h4-7H,1H2,2-3H3,(H,13,15)
    Synonyms
    N-(2-Chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide
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Frequently Asked Questions

What can I find under E1/E2/E3 Enzyme?
This listing collects compounds associated with E1/E2/E3 Enzyme within our Metabolic Enzyme/Protease area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for E1/E2/E3 Enzyme?
Consider the reported potency of each E1/E2/E3 Enzyme compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for E1/E2/E3 Enzyme compounds?
Each E1/E2/E3 Enzyme product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search E1/E2/E3 Enzyme compounds by activity or structure?
Yes. Filter the E1/E2/E3 Enzyme listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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