Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.
JAK/STAT Signaling
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- Fedratinib (SAR302503, TG101348), Tyrosine-protein kinase JAK2 inhibitorCAS: 936091-26-8 EC Number: 829-304-9 PubChem CID: 16722836 Formula: C27H36N6O3S Molecular Weight: 524.68Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: T126330View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
- SMILES
- CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4
- InChIKey
- JOOXLOJCABQBSG-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- 7.ALPHA.-METHYLNORETHINDRONE | FEDRATINIB [WHO-DD] | NSC800099 | NSC-800099 | N-Tert-butyl-3-(5-methyl-2-(4-(2-pyrrol...
- PIM-1 Inhibitor 2Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: P275472View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidin-2-amine
- SMILES
- C1=CC(=CC=C1C2=C3C=C(C=CC3=NO2)C4=NC(=NC=C4)N)Cl
- InChIKey
- AQVFETGXIRKVAQ-UHFFFAOYSA-N
- InChI
- 1S/C17H11ClN4O/c18-12-4-1-10(2-5-12)16-13-9-11(3-6-15(13)22-23-16)14-7-8-20-17(19)21-14/h1-9H,(H2,19,20,21)
- Synonyms
- HMS3414A13 | AKOS005074822 | benzisoxazole-pyrimidine, 2 | HY-108605 | CUA84512 | PIM 1 Inhibitor 2 | UNII-QJ8ZMA6BSL...
- Tofacitinib(CP-690550), Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of protein kinase N1;Inhibitor of tyrosine kinase 2CAS: 477600-75-2 EC Number: 689-145-4 PubChem CID: 9926791 Formula: C16H20N6O Molecular Weight: 312.37Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)● In Stock — US warehouse, ships to EU* Item #: T122330View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile
- SMILES
- CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N
- InChIKey
- UJLAWZDWDVHWOW-YPMHNXCESA-N
- InChI
- 1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
- Synonyms
- 1-PIPERIDINEPROPANENITRILE, 4-METHYL-3-(METHYL-7H-PYRROLO(2,3-D)PYRIMIDIN-4-YLAMINO)-.BETA.-OXO-, (3R,4R)- | NSC78235...
- WZ3146● In Stock — US warehouse, ships to EU* Item #: W127717View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
- SMILES
- CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl
- InChIKey
- APHGZZPEOCCYNO-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- A891789 | n',n'-diisopropyl-ethane-1,2-diamine | AS-55862 | N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrim...
- Triacetyl resveratrolCAS: 42206-94-0 EC Number: 695-560-1 PubChem CID: 5962587 Formula: C20H18O6 Molecular Weight: 354.35● In Stock — US warehouse, ships to EU* Item #: T133704View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- [4-[(E)-2-(3,5-diacetyloxyphenyl)ethenyl]phenyl] acetate
- SMILES
- CC(=O)OC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC(=O)C)OC(=O)C
- InChIKey
- PDAYUJSOJIMKIS-SNAWJCMRSA-N
- InChI
- 1S/C20H18O6/c1-13(21)24-18-8-6-16(7-9-18)4-5-17-10-19(25-14(2)22)12-20(11-17)26-15(3)23/h4-12H,1-3H3/b5-4+
- Synonyms
- 3,4',5-Triacetoxy-trans-stilbene | AC-34935 | NCGC00095675-02 | NSC793317 | NSC-793317 | [4-[(E)-2-(3,5-diacetyloxyph...
- WZ4002, Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 4;Inhibitor of IL2 inducible T cell kinase;Inhibitor of NUAK familyMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: W127713View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
- SMILES
- CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC
- InChIKey
- ITTRLTNMFYIYPA-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- NCGC00263144-02 | CCG-264847 | s1173 | WZ 4002 | N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimi...
- PD168393CAS: 194423-15-9 Formula: C17H13BrN4O Molecular Weight: 369.22● In Stock — US warehouse, ships to EU* Item #: P129447View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide
- SMILES
- C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br
- InChIKey
- HTUBKQUPEREOGA-UHFFFAOYSA-N
- InChI
- 1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
- Synonyms
- 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline | F13662 | BDBM4567 | NCGC00386260-02 | 3R996Y9T0I | AS-67687 | n-{4...
- LY 456236 hydrochloride● In Stock — US warehouse, ships to EU* Item #: L274794View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6-methoxy-N-(4-methoxyphenyl)quinazolin-4-amine;hydrochloride
- SMILES
- COC1=CC=C(C=C1)NC2=NC=NC3=C2C=C(C=C3)OC.Cl
- InChIKey
- AVKFOWUSTVWZQN-UHFFFAOYSA-N
- InChI
- 1S/C16H15N3O2.ClH/c1-20-12-5-3-11(4-6-12)19-16-14-9-13(21-2)7-8-15(14)17-10-18-16;/h3-10H,1-2H3,(H,17,18,19);1H
- Synonyms
- Avasimibe (USAN/INN) | LY456236 | LY-456236 | 6-methoxy-N-(4-methoxyphenyl)quinazolin-4-amine hydrochloride. | A92450...
- NiclosamideSolid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — Germany Item #: N130841View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
- SMILES
- C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
- InChIKey
- RJMUSRYZPJIFPJ-UHFFFAOYSA-N
- InChI
- 1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
- Synonyms
- NCGC00015735-07 | SCHEMBL67182 | Spectrum5_001083 | 2',5-Dichloro-4'-nitrosalicylanilide | CHEBI:7553 | BAY-2353 | Ni...
- S-Ruxolitinib (INCB018424), Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: S129613View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
- SMILES
- C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
- InChIKey
- HFNKQEVNSGCOJV-HNNXBMFYSA-N
- InChI
- 1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m0/s1
- Synonyms
- AC-30902 | F85017 | HY-50856A | Ruxolitinib S enantiomer | EX-A4005 | 1H-Pyrazole-1-propanenitrile, beta-cyclopentyl-...
- SB1317, Tyrosine-protein kinase JAK2 inhibitorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: S127924View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (16E)-14-methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene
- SMILES
- CN1CC=CCCOC2=CC=CC(=C2)C3=NC(=NC=C3)NC4=CC=CC(=C4)C1
- InChIKey
- VXBAJLGYBMTJCY-NSCUHMNNSA-N
- InChI
- show more
- Synonyms
- NSC762673 | NSC-762673 | EX-A7310 | 20-Oxa-5,7,14,27-tetraazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8...
- GenisteinMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%● In Stock — US warehouse, ships to EU* Item #: G106673View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
- SMILES
- C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O
- InChIKey
- TZBJGXHYKVUXJN-UHFFFAOYSA-N
- InChI
- 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
- Synonyms
- cid_5280961 | GTPL2826 | BRN 0263823 | DH2M523P0H | MolMap_000022 | GENISTEIN (USP-RS) | Differenol A | GENISTEIN [MI...
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R&D Use Only Products supplied for research and development use
Frequently Asked Questions
What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].