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JAK/STAT Signaling

Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.

Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.

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STAT

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  1. CP-724714
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    CP-724714
    CAS: 537705-08-1 PubChem CID: 57345837 Formula: C27H27N5O3 Molecular Weight: 469.53
    ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: C129397
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    Technical Identifiers
    Synonyms
    (E)-2-methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)acetamide | 2-Methoxy-N-...
  2. CP-724714 - Moligand™, ≥98% CAS No(383432-38-0) by Aladdin Scientific
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    CP-724714, Receptor protein-tyrosine kinase erbB-2 inhibitor
    CAS: 383432-38-0 Formula: C27H27N5O3 Molecular Weight: 469.54
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C125489
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    IUPAC Name
    2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide
    SMILES
    CC1=NC=C(C=C1)OC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)C=CCNC(=O)COC)C
    InChIKey
    LLVZBTWPGQVVLW-SNAWJCMRSA-N
    InChI
    1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3show more
    Synonyms
    2-methoxy-N-[(2E)-3-[4-({3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}amino)quinazolin-6-yl]prop-2-en-1-yl]acetamide ...
  3. CNX-2006
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    CNX-2006
    CAS: 1375465-09-0 Formula: C26H27F4N7O2 Molecular Weight: 545.53
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C421426
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    Technical Identifiers
    IUPAC Name
    N-[3-[[2-[4-[[1-(2-fluoroethyl)azetidin-3-yl]amino]-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
    SMILES
    COC1=C(C=CC(=C1)NC2CN(C2)CCF)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F
    InChIKey
    BFSRTTWIPACGMI-UHFFFAOYSA-N
    InChI
    1S/C26H27F4N7O2/c1-3-23(38)33-16-5-4-6-17(11-16)34-24-20(26(28,29)30)13-31-25(36-24)35-21-8-7-18(12-22(21)39-2)32-19-14-37(15-19)10-9-27/h3-8,11-13,19show more
    Synonyms
    2-Propenamide,N-[3-[[2-[[4-[[1-(2-fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrim...
  4. CNX-2006
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    CNX-2006
    CAS: 1375465-09-0 Formula: C26H27F4N7O2 Molecular Weight: 545.53
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C413721
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    Technical Identifiers
    IUPAC Name
    N-[3-[[2-[4-[[1-(2-fluoroethyl)azetidin-3-yl]amino]-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
    SMILES
    COC1=C(C=CC(=C1)NC2CN(C2)CCF)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F
    InChIKey
    BFSRTTWIPACGMI-UHFFFAOYSA-N
    InChI
    1S/C26H27F4N7O2/c1-3-23(38)33-16-5-4-6-17(11-16)34-24-20(26(28,29)30)13-31-25(36-24)35-21-8-7-18(12-22(21)39-2)32-19-14-37(15-19)10-9-27/h3-8,11-13,19show more
    Synonyms
    2-Propenamide,N-[3-[[2-[[4-[[1-(2-fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrim...
  5. CO-1686 (AVL-301), Epidermal growth factor receptor erbB1 inhibitor
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    CO-1686 (AVL-301), Epidermal growth factor receptor erbB1 inhibitor
    CAS: 1374640-70-6 EC Number: 811-332-8 Formula: C27H28F3N7O3 Molecular Weight: 555.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: C124905
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    Technical Identifiers
    IUPAC Name
    N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
    SMILES
    CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC
    InChIKey
    HUFOZJXAKZVRNJ-UHFFFAOYSA-N
    InChI
    1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16show more
    Synonyms
    NSC779405 | NSC-779405 | s7284 | NCGC00386293-08 | SB16488 | HUFOZJXAKZVRNJ-UHFFFAOYSA-N | CO1686 | CO-1686 | DB11907...
  6. CO-1686 (AVL-301), Epidermal growth factor receptor erbB1 inhibitor
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    CO-1686 (AVL-301), Epidermal growth factor receptor erbB1 inhibitor
    CAS: 1374640-70-6 EC Number: 811-332-8 Formula: C27H28F3N7O3 Molecular Weight: 555.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C421423
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    Technical Identifiers
    IUPAC Name
    N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
    SMILES
    CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC
    InChIKey
    HUFOZJXAKZVRNJ-UHFFFAOYSA-N
    InChI
    1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16show more
    Synonyms
    NSC779405 | NSC-779405 | s7284 | NCGC00386293-08 | SB16488 | HUFOZJXAKZVRNJ-UHFFFAOYSA-N | CO1686 | CO-1686 | DB11907...
  7. CX-6258, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinase
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    CX-6258, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-2 proto-oncogene; serine/threonine kinase;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinase
    CAS: 1202916-90-2 Formula: C26H24ClN3O3 Molecular Weight: 461.94
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C126466
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    Technical Identifiers
    IUPAC Name
    (3E)-5-chloro-3-[[5-[3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]furan-2-yl]methylidene]-1H-indol-2-one
    SMILES
    CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)C=C4C5=C(C=CC(=C5)Cl)NC4=O
    InChIKey
    KGBPLKOPSFDBOX-CJLVFECKSA-N
    InChI
    1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,show more
    Synonyms
    CX6258 | CX 6258 | (3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methyl...
  8. CX-6258 HCl
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    CX-6258 HCl
    CAS: 1353859-00-3 Formula: C26H24ClN3O3.HCl Molecular Weight: 498.4
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C421345
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    Technical Identifiers
    IUPAC Name
    (3E)-5-chloro-3-[[5-[3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]furan-2-yl]methylidene]-1H-indol-2-one;hydrochloride
    SMILES
    CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)C=C4C5=C(C=CC(=C5)Cl)NC4=O.Cl
    InChIKey
    YYIMMVXTWBIEAG-YHLMHSEJSA-N
    InChI
    1S/C26H24ClN3O3.ClH/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31;/h2,4-9,14-16H,3,10-13H2show more
    Synonyms
    (3E)-5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H...
  9. CX-6258 HCl
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    CX-6258 HCl
    CAS: 1353859-00-3 Formula: C26H24ClN3O3.HCl Molecular Weight: 498.4
    ≥97%
    ● In Stock — US warehouse, ships to EU* Item #: C413706
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    Technical Identifiers
    IUPAC Name
    (3E)-5-chloro-3-[[5-[3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]furan-2-yl]methylidene]-1H-indol-2-one;hydrochloride
    SMILES
    CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)C=C4C5=C(C=CC(=C5)Cl)NC4=O.Cl
    InChIKey
    YYIMMVXTWBIEAG-YHLMHSEJSA-N
    InChI
    1S/C26H24ClN3O3.ClH/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31;/h2,4-9,14-16H,3,10-13H2show more
    Synonyms
    Pim-Kinase Inhibitor X | CX-6258 hydrochloride
  10. CRT0066101 dihydrochloride
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    CRT0066101 dihydrochloride
    CAS: 1883545-60-5 PubChem CID: 136664697 Formula: C18H22N6O.2HCl Molecular Weight: 411.33
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C275429
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    Technical Identifiers
    IUPAC Name
    2-[4-[[(2R)-2-aminobutyl]amino]pyrimidin-2-yl]-4-(1-methylpyrazol-4-yl)phenol;dihydrochloride
    SMILES
    CCC(CNC1=NC(=NC=C1)C2=C(C=CC(=C2)C3=CN(N=C3)C)O)N.Cl.Cl
    InChIKey
    CXYCRYGNFKDPRH-FMOMHUKBSA-N
    InChI
    1S/C18H22N6O.2ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;;/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23);2*1H/t14-;show more
    Synonyms
    CRT0066101 2HCl | 2-[4-[[(2R)-2-Aminobutyl]amino]pyrimidin-2-yl]-4-(1-methyl-1H-pyrazol-4-yl)phenoldihydrochloride
  11. CRT0066101 - 10mM in DMSO CAS No(1883545-60-5) by Aladdin Scientific
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    CRT0066101
    CAS: 1883545-60-5 EC Number: 890-584-0 PubChem CID: 136664697 Formula: C18H22N6O.2HCl Molecular Weight: 411.33
    Liquid 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: C422303
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    Technical Identifiers
    IUPAC Name
    2-[4-[[(2R)-2-aminobutyl]amino]pyrimidin-2-yl]-4-(1-methylpyrazol-4-yl)phenol;dihydrochloride
    SMILES
    CCC(CNC1=NC(=NC=C1)C2=C(C=CC(=C2)C3=CN(N=C3)C)O)N.Cl.Cl
    InChIKey
    CXYCRYGNFKDPRH-FMOMHUKBSA-N
    InChI
    1S/C18H22N6O.2ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;;/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23);2*1H/t14-;show more
    Synonyms
    2-[4-[[(2R)-2-Aminobutyl]amino]pyrimidin-2-yl]-4-(1-methyl-1H-pyrazol-4-yl)phenoldihydrochloride
  12. CUDC-101, Histone deacetylase inhibitor
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    CUDC-101, Histone deacetylase inhibitor
    CAS: 1012054-59-9 Formula: C24H26N4O4 Molecular Weight: 434.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: C127191
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    Technical Identifiers
    IUPAC Name
    7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide
    SMILES
    COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
    InChIKey
    PLIVFNIUGLLCEK-UHFFFAOYSA-N
    InChI
    1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28show more
    Synonyms
    7-((4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide | AS-16955 | FT-0665231 | UNII-1A7Y9M...
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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].
JAK/STAT signaling pages help researchers compare compounds relevant to cytokine signaling, transcriptional response, immune biology, and proliferative disease studies. Key evaluation points often include pathway node, isoform selectivity, upstream receptor context, cellular potency, biomarker response, and disease relevance. This category is useful when experiments need to connect receptor-level signaling with transcriptional outcomes across related pathway nodes. It supports both mechanism studies and discovery-stage compound selection.
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