By Signaling Pathways - JAK/STAT Signaling Supplier | High Purity

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Erlotinib-d6 HCl
CAS: 1189953-78-3 Formula: C₂₂H₁₈D₆ClN₃O₄ Molecular Weight: 399.48 + 36.46

≥98 atom% D

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IUPAC Name

N-(3-ethynylphenyl)-6,7-bis[2-(trideuteriomethoxy)ethoxy]quinazolin-4-amine;hydrochloride

SMILES

COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl

InChIKey
GTTBEUCJPZQMDZ-HVTBMTIBSA-N

InChI

1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H/show more

Synonyms
Tarceva-d3 | N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy-d3)-4-quinazolinamine Hydrochloride
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FLLL32
CAS: 1226895-15-3 Formula: C₂₈H₃₂O₆ Molecular Weight: 464.55

10mM in DMSO

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IUPAC Name

(E)-3-(3,4-dimethoxyphenyl)-1-[1-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]cyclohexyl]prop-2-en-1-one

SMILES

COC1=C(C=C(C=C1)C=CC(=O)C2(CCCCC2)C(=O)C=CC3=CC(=C(C=C3)OC)OC)OC

InChIKey
NQDROBVIYYEMDQ-WFYKWJGLSA-N

InChI

1S/C28H32O6/c1-31-22-12-8-20(18-24(22)33-3)10-14-26(29)28(16-6-5-7-17-28)27(30)15-11-21-9-13-23(32-2)25(19-21)34-4/h8-15,18-19H,5-7,16-17H2,1-4H3/b14-show more

Synonyms
(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)-2-propen-1-one
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FM-381
CAS: 2226521-65-7 Formula: C₂₄H₂₄N₆O₂ Molecular Weight: 428.49

≥98%

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IUPAC Name

(E)-2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide

SMILES

CN(C)C(=O)C(=CC1=CC=C(O1)C2=NC3=CN=C4C(=C3N2C5CCCCC5)C=CN4)C#N

InChIKey
GJMZWYLOARVASY-NTCAYCPXSA-N

InChI

1S/C24H24N6O2/c1-29(2)24(31)15(13-25)12-17-8-9-20(32-17)23-28-19-14-27-22-18(10-11-26-22)21(19)30(23)16-6-4-3-5-7-16/h8-12,14,16H,3-7H2,1-2H3,(H,26,27show more

Synonyms
(E)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
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FLLL32
CAS: 1226895-15-3 Formula: C₂₈H₃₂O₆ Molecular Weight: 464.55

≥98%

● In Stock — US warehouse, ships to EU* Item #: F413726
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IUPAC Name

(E)-3-(3,4-dimethoxyphenyl)-1-[1-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]cyclohexyl]prop-2-en-1-one

SMILES

COC1=C(C=C(C=C1)C=CC(=O)C2(CCCCC2)C(=O)C=CC3=CC(=C(C=C3)OC)OC)OC

InChIKey
NQDROBVIYYEMDQ-WFYKWJGLSA-N

InChI

1S/C28H32O6/c1-31-22-12-8-20(18-24(22)33-3)10-14-26(29)28(16-6-5-7-17-28)27(30)15-11-21-9-13-23(32-2)25(19-21)34-4/h8-15,18-19H,5-7,16-17H2,1-4H3/b14-show more

Synonyms
(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)-2-propen-1-one
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Filgotinib (GLPG0634), Tyrosine-protein kinase JAK1 inhibitor
CAS: 1206161-97-8 EC Number: 858-411-3 Formula: C₂₁H₂₃N₅O₃S Molecular Weight: 425.5

Moligand™ ? ≥98%

● In Stock — US warehouse, ships to EU* Item #: F413789
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IUPAC Name

N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

SMILES

C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5

InChIKey
RIJLVEAXPNLDTC-UHFFFAOYSA-N

InChI

1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)

Synonyms
AMY3802 | AS-16295 | BCP08496 | N-(5-{4-[(1,1-dioxo-1lambda6-thiomorpholin-4-yl)methyl]phenyl}-[1,2,4]triazolo[1,5-a]...
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Filgotinib (GLPG0634), Tyrosine-protein kinase JAK1 inhibitor
CAS: 1206161-97-8 EC Number: 858-411-3 Formula: C₂₁H₂₃N₅O₃S Molecular Weight: 425.5

Moligand™ ? 10mM in DMSO

● In Stock — US warehouse, ships to EU* Item #: F420902
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Technical Identifiers

IUPAC Name

N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

SMILES

C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5

InChIKey
RIJLVEAXPNLDTC-UHFFFAOYSA-N

InChI

1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)

Synonyms
AMY3802 | AS-16295 | BCP08496 | N-(5-{4-[(1,1-dioxo-1lambda6-thiomorpholin-4-yl)methyl]phenyl}-[1,2,4]triazolo[1,5-a]...
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Flubendazole
CAS: 31430-15-6 EC Number: 250-624-4 Formula: C₁₆H₁₂FN₃O₃ Molecular Weight: 313.28

2mM in DMSO

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IUPAC Name

methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate

SMILES

COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=C(C=C3)F

InChIKey
CPEUVMUXAHMANV-UHFFFAOYSA-N

InChI

1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

Synonyms
Flubendazole|31430-15-6|Flumoxane|Flubendazol|Fluvermal|Flubenol|Flubendazolum|Flumoxal|Methyl (5-(4-fluorobenzoyl)-1...
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Fraxinellone
CAS: 28808-62-0 Formula: C₁₄H₁₆O₃ Molecular Weight: 232.28

10mM in DMSO

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IUPAC Name

(3R,3aR)-3-(furan-3-yl)-3a,7-dimethyl-3,4,5,6-tetrahydro-2-benzofuran-1-one

SMILES

CC1=C2C(=O)OC(C2(CCC1)C)C3=COC=C3

InChIKey
XYYAFLHHHZVPRN-GXTWGEPZSA-N

InChI

1S/C14H16O3/c1-9-4-3-6-14(2)11(9)13(15)17-12(14)10-5-7-16-8-10/h5,7-8,12H,3-4,6H2,1-2H3/t12-,14+/m0/s1

Synonyms
(3R,3aR)-3-(uran-3-yl)-3a,7-dimethyl-3,4,5,6-tetrahydro-2-benzouran-1-one | F1187 | NCI60_012928 | 4-(m-chlorophenyl)...
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GDC046
CAS: 1258292-64-6 Formula: C₁₆H₁₃Cl₂N₃O₂ Molecular Weight: 350.2

10mM in DMSO

● In Stock — US warehouse, ships to EU* Item #: G421085
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IUPAC Name

2,6-dichloro-N-[2-(cyclopropanecarbonylamino)pyridin-4-yl]benzamide

SMILES

C1CC1C(=O)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl

InChIKey
IAFNAEGXTKTGHN-UHFFFAOYSA-N

InChI

1S/C16H13Cl2N3O2/c17-11-2-1-3-12(18)14(11)16(23)20-10-6-7-19-13(8-10)21-15(22)9-4-5-9/h1-3,6-9H,4-5H2,(H2,19,20,21,22,23)

Synonyms
Benzamide,2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-
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GDC046
CAS: 1258292-64-6 Formula: C₁₆H₁₃Cl₂N₃O₂ Molecular Weight: 350.2

≥99%

● In Stock — US warehouse, ships to EU* Item #: G412348
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IUPAC Name

2,6-dichloro-N-[2-(cyclopropanecarbonylamino)pyridin-4-yl]benzamide

SMILES

C1CC1C(=O)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl

InChIKey
IAFNAEGXTKTGHN-UHFFFAOYSA-N

InChI

1S/C16H13Cl2N3O2/c17-11-2-1-3-12(18)14(11)16(23)20-10-6-7-19-13(8-10)21-15(22)9-4-5-9/h1-3,6-9H,4-5H2,(H2,19,20,21,22,23)

Synonyms
Benzamide,2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-
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GMB-475
CAS: 2490599-18-1 Formula: Molecular Weight: 861.93

≥98%

● In Stock — US warehouse, ships to EU* Item #: G414246
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Synonyms
(2S)-1-((R)-3,3-dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)but...
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GLPG0634 analogue
CAS: 1206101-20-3 Formula: C₂₃H₁₈N₆O₂ Molecular Weight: 410.43

≥97%

● In Stock — US warehouse, ships to EU* Item #: G413713
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IUPAC Name

N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

SMILES

C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5

InChIKey
RIJLVEAXPNLDTC-UHFFFAOYSA-N

InChI

1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)

Synonyms
AMY3802 | AS-16295 | BCP08496 | N-(5-{4-[(1,1-dioxo-1lambda6-thiomorpholin-4-yl)methyl]phenyl}-[1,2,4]triazolo[1,5-a]...

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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?

Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.

Which JAK/STAT Signaling subcategory should I start with?

JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.

Which quality data should I check before ordering JAK/STAT Signaling?

Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.

Can I search JAK/STAT Signaling by structure or CAS number?

Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].

JAK/STAT signaling pages help researchers compare compounds relevant to cytokine signaling, transcriptional response, immune biology, and proliferative disease studies. Key evaluation points often include pathway node, isoform selectivity, upstream receptor context, cellular potency, biomarker response, and disease relevance. This category is useful when experiments need to connect receptor-level signaling with transcriptional outcomes across related pathway nodes. It supports both mechanism studies and discovery-stage compound selection.