Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.
JAK/STAT Signaling
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- Decernotinib (VX-509), Tyrosine-protein kinase JAK3 inhibitorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: D427037View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-(2,2,2-trifluoroethyl)butanamide
- SMILES
- CCC(C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3
- InChIKey
- ASUGUQWIHMTFJL-QGZVFWFLSA-N
- InChI
- show more
- Synonyms
- Butanamide, 2-methyl-2-((2-(1H-pyrrolo(2,3-b)pyridin-3-yl)-4-pyrimidinyl)amino)-N-(2,2,2-trifluoroethyl)-, (2R)- | F1...
- Deucravacitinib (BMS-986165), Tyrosine-protein kinase TYK2 negative allosteric modulatorMoligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: D414239View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide
- SMILES
- CNC(=O)C1=NN=C(C=C1NC2=CC=CC(=C2OC)C3=NN(C=N3)C)NC(=O)C4CC4
- InChIKey
- BZZKEPGENYLQSC-FIBGUPNXSA-N
- InChI
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- Synonyms
- Deucravacitinib | NSC825520 | compound 11 [PMID: 31318208} | EN300-22276121 | Deucravacitinib [USAN] | (BMS-986165) |...
- EAI045, Allosteric modulator of epidermal growth factor receptorCAS: 1942114-09-1 Formula: C19H14FN3O3S Molecular Weight: 383.4Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%● In Stock — US warehouse, ships to EU* Item #: E413951View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
- SMILES
- C1C2=CC=CC=C2C(=O)N1C(C3=C(C=CC(=C3)F)O)C(=O)NC4=NC=CS4
- InChIKey
- YTUFHOKUFOQRDF-UHFFFAOYSA-N
- InChI
- 1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)
- Synonyms
- 2H-Isoindole-2-acetamide,α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl- | (Z)-2-(5-flu...
- EGFR inhibitor, Inhibitor of epidermal growth factor receptorCAS: 879127-07-8 Formula: C21H18F3N5O Molecular Weight: 413.4Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: E337818View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide
- SMILES
- C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F
- InChIKey
- YOHYSYJDKVYCJI-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- K00598a | AKOS000120473 | EGFR inhibitor(YUN27078) | EGFR Inhibitor [879127-07-8] | EGFR Inhibitor - CAS 879127-07-8 ...
- EAI045, Allosteric modulator of epidermal growth factor receptorCAS: 1942114-09-1 Formula: C19H14FN3O3S Molecular Weight: 383.4Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: E422370View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide
- SMILES
- C1C2=CC=CC=C2C(=O)N1C(C3=C(C=CC(=C3)F)O)C(=O)NC4=NC=CS4
- InChIKey
- YTUFHOKUFOQRDF-UHFFFAOYSA-N
- InChI
- 1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)
- Synonyms
- 2H-Isoindole-2-acetamide,α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-
- EBE-A22CAS: 229476-53-3 Formula: C17H16BrN3O2 Molecular Weight: 374.2310mM in DMSO● In Stock — US warehouse, ships to EU* Item #: E422730View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine
- SMILES
- CN(C1=CC(=CC=C1)Br)C2=NC=NC3=CC(=C(C=C32)OC)OC
- InChIKey
- IPWGDOZPSOZFOD-UHFFFAOYSA-N
- InChI
- 1S/C17H16BrN3O2/c1-21(12-6-4-5-11(18)7-12)17-13-8-15(22-2)16(23-3)9-14(13)19-10-20-17/h4-10H,1-3H3
- Synonyms
- EBE-A 22;EBE A22; EBEA22 | MS-26039 | N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine | s6530 | AKOS030526...
- EGFR-IN-5CAS: 2225887-26-1 Formula: C31H38FN9O Molecular Weight: 571.69◐ .Made to order · 8–12 wks Item #: E413697View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- [1-[6-[[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]amino]-2-(4-fluoroanilino)pyrido[3,4-d]pyrimidin-4-yl]piperidin-4-yl]methanol
- SMILES
- CN(C)C1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C(=C3)C(=NC(=N4)NC5=CC=C(C=C5)F)N6CCC(CC6)CO
- InChIKey
- DXOUQSZKEPSXBC-UHFFFAOYSA-N
- InChI
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- EGFR-IN-7CAS: 2267329-76-8 Formula: C32H41BrN9O2P Molecular Weight: 694.60● In Stock — US warehouse, ships to EU* Item #: E401064View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 5-bromo-4-N-(5-dimethylphosphorylquinoxalin-6-yl)-2-N-[2-methoxy-5-methyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine
- SMILES
- CC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)C)OC)NC4=NC=C(C(=N4)NC5=C(C6=NC=CN=C6C=C5)P(=O)(C)C)Br
- InChIKey
- ZYSKXRAGBGLELB-UHFFFAOYSA-N
- InChI
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- Synonyms
- TQB3804
- EGFR/ErbB-2/ErbB-4 inhibitor-2 , Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2CAS: 179248-61-4 Formula: C23H21N3O3 Molecular Weight: 387.43Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: E337825View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine
- SMILES
- COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC
- InChIKey
- DNOKYISWMVFYFA-UHFFFAOYSA-N
- InChI
- 1S/C23H21N3O3/c1-27-21-12-19-20(13-22(21)28-2)24-15-25-23(19)26-17-8-10-18(11-9-17)29-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,24,25,26)
- Synonyms
- 4557W | 4-Quinazolinamine, 6,7-dimethoxy-N-[4-(phenylmethoxy)phenyl]- | EGFR/ErbB2 Inhibitor | EGFR/ErbB-2 Inhibitor ...
- EGFR inhibitor, Inhibitor of epidermal growth factor receptorCAS: 879127-07-8 Formula: C21H18F3N5O Molecular Weight: 413.4Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: E426643View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide
- SMILES
- C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F
- InChIKey
- YOHYSYJDKVYCJI-UHFFFAOYSA-N
- InChI
- show more
- Synonyms
- K00598a | AKOS000120473 | EGFR inhibitor(YUN27078) | EGFR Inhibitor [879127-07-8] | EGFR Inhibitor - CAS 879127-07-8 ...
- Epertinib hydrochloride◐ .Made to order · 8–12 wks Item #: E413670View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[(Z)-N-[[(3R)-morpholin-3-yl]methoxy]-C-prop-1-ynylcarbonimidoyl]quinazolin-4-amine;hydrochloride
- SMILES
- CC#CC(=NOCC1COCCN1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl
- InChIKey
- NVWJPQQXBPWOOA-PLXRJBJVSA-N
- InChI
- show more
- Synonyms
- Epertinib HCl | S-222611 hydrochloride | S-222611 HCl
- EquisetinCAS: 57749-43-6 Formula: C22H31NO4 Molecular Weight: 373.49◐ .Made to order · 8–12 wks Item #: E329522View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- show more
- SMILES
- CC=CC1C=CC2CC(CCC2C1(C)C(=C3C(=O)C(N(C3=O)C)CO)O)C
- InChIKey
- QNQBPPQLRODXET-AIMHRHHOSA-N
- InChI
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- Synonyms
- V56ZMM5VMZ | Equisetin | HY-N6711 | DTXSID001017630 | QNQBPPQLRODXET-AIMHRHHOSA-N | 2,4-Pyrrolidinedione, 5-(hydroxym...
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R&D Use Only Products supplied for research and development use
Frequently Asked Questions
What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].