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JAK/STAT Signaling

Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.

Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.

1,726 products
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EGFR

852

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JAK

448

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Pim

83

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STAT

418

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Showing 457-468 of 1,726

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  1. Tucatinib (Irbinitinib, ONT-380), Receptor protein-tyrosine kinase erbB-2 inhibitor
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    Tucatinib (Irbinitinib, ONT-380), Receptor protein-tyrosine kinase erbB-2 inhibitor
    CAS: 937263-43-9 EC Number: 876-089-2 PubChem CID: 51039094 Formula: C26H24N8O2 Molecular Weight: 480.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: T413986
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    Technical Identifiers
    IUPAC Name
    6-N-(4,4-dimethyl-5H-1,3-oxazol-2-yl)-4-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine
    SMILES
    CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5
    InChIKey
    SDEAXTCZPQIFQM-UHFFFAOYSA-N
    InChI
    1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,show more
    Synonyms
    Irbinitinib | ONT-380 | Q25100690 | 6-N-(4,4-dimethyl-5H-1,3-oxazol-2-yl)-4-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyri...
  2. Tropisetron, Antagonist of 5-HT 3A;Antagonist of 5-HT 4 receptor;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Antagonist of glycine receptor β subunit
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    Tropisetron, Antagonist of 5-HT 3A;Antagonist of 5-HT 4 receptor;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Antagonist of glycine receptor β subunit
    CAS: 89565-68-4 PubChem CID: 656665 Formula: C17H20N2O2 Molecular Weight: 284.35
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US warehouse, ships to EU* Item #: T127885
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    Technical Identifiers
    IUPAC Name
    [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate
    SMILES
    CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43
    InChIKey
    ZNRGQMMCGHDTEI-FUNVUKJBSA-N
    InChI
    1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13?
    Synonyms
    [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate | TROPISETRON [WHO-DD] | Tropisteron | HY-B0...
  3. Tyrphostin AG 494
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    Tyrphostin AG 494
    CAS: 133550-35-3 EC Number: 810-936-9 PubChem CID: 5328771 Formula: C16H12N2O3 Molecular Weight: 280.28
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: T421272
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    Technical Identifiers
    IUPAC Name
    (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide
    SMILES
    C1=CC=C(C=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
    InChIKey
    HKHOVJYOELRGMV-XYOKQWHBSA-N
    InChI
    1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
    Synonyms
    MKXZASYAUGDDCJ-UHFFFAOYSA-N | DTXSID201018515 | HMS3414I07 | s6509 | AKOS024458583 | HMS2232N04 | NCGC00024687-02 | B...
  4. Tyrphostin AG 528
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    Tyrphostin AG 528
    CAS: 133550-49-9 EC Number: 834-693-3 PubChem CID: 1838043 Formula: C18H14N2O3 Molecular Weight: 306.32
    ◐ .Made to order · 8–12 wks Item #: T394670
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    Technical Identifiers
    IUPAC Name
    (E)-2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
    SMILES
    C1CN(C2=CC=CC=C21)C(=O)C(=CC3=CC(=C(C=C3)O)O)C#N
    InChIKey
    MYKCTDWWIWGLHW-NTEUORMPSA-N
    InChI
    1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+
    Synonyms
    AC-35701 | BCP24141 | AG 528 | BDBM4314 | EX-A2364 | SMR001230652 | (2E)-2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-3-(3,4...
  5. Tyrphostin AG 528
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    Tyrphostin AG 528
    CAS: 133550-49-9 EC Number: 834-693-3 PubChem CID: 1838043 Formula: C18H14N2O3 Molecular Weight: 306.32
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: T337635
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    Technical Identifiers
    IUPAC Name
    (E)-2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
    SMILES
    C1CN(C2=CC=CC=C21)C(=O)C(=CC3=CC(=C(C=C3)O)O)C#N
    InChIKey
    MYKCTDWWIWGLHW-NTEUORMPSA-N
    InChI
    1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+
    Synonyms
    AC-35701 | BCP24141 | AG 528 | BDBM4314 | EX-A2364 | SMR001230652 | (2E)-2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-3-(3,4...
  6. Tyrphostin AG 528
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    Tyrphostin AG 528
    CAS: 133550-49-9 EC Number: 834-693-3 PubChem CID: 1838043 Formula: C18H14N2O3 Molecular Weight: 306.32
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: T421273
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (E)-2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
    SMILES
    C1CN(C2=CC=CC=C21)C(=O)C(=CC3=CC(=C(C=C3)O)O)C#N
    InChIKey
    MYKCTDWWIWGLHW-NTEUORMPSA-N
    InChI
    1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+
    Synonyms
    AC-35701 | BCP24141 | AG 528 | BDBM4314 | EX-A2364 | SMR001230652 | (2E)-2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-3-(3,4...
  7. Tyrphostin RG 14620
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    Tyrphostin RG 14620
    CAS: 136831-49-7 PubChem CID: 5353928 Formula: C14H8Cl2N2 Molecular Weight: 275.1
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: T421398
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    Technical Identifiers
    IUPAC Name
    (E)-3-(3,5-dichlorophenyl)-2-pyridin-3-ylprop-2-enenitrile
    SMILES
    C1=CC(=CN=C1)C(=CC2=CC(=CC(=C2)Cl)Cl)C#N
    InChIKey
    TYXIVBJQPBWBHO-QCDXTXTGSA-N
    InChI
    1S/C14H8Cl2N2/c15-13-5-10(6-14(16)7-13)4-12(8-17)11-2-1-3-18-9-11/h1-7,9H/b12-4-
    Synonyms
    (E)-3-(3,5-dichlorophenyl)-2-(pyridin-3-yl)acrylonitrile | MFCD00236445 | (E)-3-(3,5-dichlorophenyl)-2-pyridin-3-ylpr...
  8. UF010
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    UF010
    CAS: 537672-41-6 PubChem CID: 4596836 Formula: C11H15BrN2O Molecular Weight: 271.15
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: U424599
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    Technical Identifiers
    IUPAC Name
    4-bromo-N'-butylbenzohydrazide
    SMILES
    CCCCNNC(=O)C1=CC=C(C=C1)Br
    InChIKey
    BVQCFCYPFJOOAV-UHFFFAOYSA-N
    InChI
    1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
    Synonyms
    Benzoic acid,4-​bromo-​,2-​butylhydrazide | 4-Bromo-benzoic acid 2-butylhydrazide | 4-bromo-N'-butylbenzohydrazide
  9. UF010
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    UF010
    CAS: 537672-41-6 PubChem CID: 4596836 Formula: C11H15BrN2O Molecular Weight: 271.15
    ≥96%
    ● In Stock — US warehouse, ships to EU* Item #: U413338
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    Technical Identifiers
    IUPAC Name
    4-bromo-N'-butylbenzohydrazide
    SMILES
    CCCCNNC(=O)C1=CC=C(C=C1)Br
    InChIKey
    BVQCFCYPFJOOAV-UHFFFAOYSA-N
    InChI
    1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
    Synonyms
    Benzoic acid,4-​bromo-​,2-​butylhydrazide | 4-Bromo-benzoic acid 2-butylhydrazide | 4-bromo-N'-butylbenzohydrazide
  10. VEGFR Tyrosine Kinase Inhibitor II, Inhibitor of kinase insert domain receptor
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    VEGFR Tyrosine Kinase Inhibitor II, Inhibitor of kinase insert domain receptor
    CAS: 269390-69-4 PubChem CID: 9797919 Formula: C19H16ClN3O Molecular Weight: 337.80
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: V338291
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    Technical Identifiers
    IUPAC Name
    N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamide
    SMILES
    C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)Cl)NCC3=CC=NC=C3
    InChIKey
    GGPZCOONYBPZEW-UHFFFAOYSA-N
    InChI
    1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24)
    Synonyms
    GTPL6056 | AKOS030580576 | N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase I...
  11. Vitexicarpin - 10mM in DMSO, CAS No. 479-91-4 by
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    Vitexicarpin
    CAS: 479-91-4 Formula: C19H18O8 Molecular Weight: 374.34
    Liquid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: V424165
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    Technical Identifiers
    IUPAC Name
    5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one
    SMILES
    COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C(=C(C=C3O2)OC)OC)O)OC)O
    InChIKey
    PJQLSMYMOKWUJG-UHFFFAOYSA-N
    InChI
    1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
    Synonyms
    DB11953 | s9288 | Casticin, primary pharmaceutical reference standard | Casticin | CASTICIN [USP-RS] | Casticin, anal...
  12. Vitexicarpin - analytical standard, ≥98%(HPLC), CAS No. 479-91-4 by Aladdin Scientific
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    Vitexicarpin
    CAS: 479-91-4 Formula: C19H18O8 Molecular Weight: 374.34
    Solid Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● In Stock — US warehouse, ships to EU* Item #: V117963
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    Technical Identifiers
    IUPAC Name
    5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one
    SMILES
    COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C(=C(C=C3O2)OC)OC)O)OC)O
    InChIKey
    PJQLSMYMOKWUJG-UHFFFAOYSA-N
    InChI
    1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
    Synonyms
    DB11953 | s9288 | Casticin, primary pharmaceutical reference standard | Casticin | CASTICIN [USP-RS] | Casticin, anal...
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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].
JAK/STAT signaling pages help researchers compare compounds relevant to cytokine signaling, transcriptional response, immune biology, and proliferative disease studies. Key evaluation points often include pathway node, isoform selectivity, upstream receptor context, cellular potency, biomarker response, and disease relevance. This category is useful when experiments need to connect receptor-level signaling with transcriptional outcomes across related pathway nodes. It supports both mechanism studies and discovery-stage compound selection.
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