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JAK/STAT Signaling

Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.

Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.

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EGFR

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STAT

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Showing 469-480 of 1,726

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  1. WAY-311753-A
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    WAY-311753-A
    CAS: 345615-74-9 PubChem CID: 769491 Formula: C16H15N3OS Molecular Weight: 297.37
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: W418505
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    Technical Identifiers
    IUPAC Name
    4-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylamino)phenol
    SMILES
    C1CCC2=C(C1)C3=C(N=CN=C3S2)NC4=CC=C(C=C4)O
    InChIKey
    BTIBWAOCLJARHL-UHFFFAOYSA-N
    InChI
    1S/C16H15N3OS/c20-11-7-5-10(6-8-11)19-15-14-12-3-1-2-4-13(12)21-16(14)18-9-17-15/h5-9,20H,1-4H2,(H,17,18,19)
  2. WAY-311753-A
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    WAY-311753-A
    CAS: 345615-74-9 PubChem CID: 769491 Formula: C16H15N3OS Molecular Weight: 297.37
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: W423521
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    4-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylamino)phenol
    SMILES
    C1CCC2=C(C1)C3=C(N=CN=C3S2)NC4=CC=C(C=C4)O
    InChIKey
    BTIBWAOCLJARHL-UHFFFAOYSA-N
    InChI
    1S/C16H15N3OS/c20-11-7-5-10(6-8-11)19-15-14-12-3-1-2-4-13(12)21-16(14)18-9-17-15/h5-9,20H,1-4H2,(H,17,18,19)
  3. WAY-339696
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    WAY-339696
    CAS: 333419-97-9 Formula: C16H11BrN2O3 Molecular Weight: 359.17414
    10mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: W423431
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    Technical Identifiers
    SMILES
    OC1=C(C(=O)NC2=CC=CC(=C2)Br)C(=O)NC3=C1C=CC=C3
  4. WHI-P180, Hydrochloride
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    WHI-P180, Hydrochloride
    CAS: 211555-08-7 PubChem CID: 5687 Formula: C16H15N3O3 Molecular Weight: 297.31
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: W422568
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    Technical Identifiers
    IUPAC Name
    3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
    SMILES
    COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)O)OC
    InChIKey
    BNDYIYYKEIXHNK-UHFFFAOYSA-N
    InChI
    1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)
    Synonyms
    DB03365 | AKOS002350928 | BDBM4622 | WHI-P180(Janex 3) | DTXSID50943478 | s6520 | Phenol, 3-[(6,7-dimethoxy-4-quinazo...
  5. WHI-P97
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    WHI-P97
    CAS: 211555-05-4 PubChem CID: 3796 Formula: C16H13Br2N3O3 Molecular Weight: 455.11
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: W422567
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    Technical Identifiers
    IUPAC Name
    2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
    SMILES
    COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C(=C3)Br)O)Br)OC
    InChIKey
    YVCXQRVVNQMZEI-UHFFFAOYSA-N
    InChI
    1S/C16H13Br2N3O3/c1-23-13-5-9-12(6-14(13)24-2)19-7-20-16(9)21-8-3-10(17)15(22)11(18)4-8/h3-7,22H,1-2H3,(H,19,20,21)
    Synonyms
    HMS3265F24 | 2,6-Dibromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol | 2,6-Dibromo-4-(6,7-dimethoxy-quinazolin-4-yl...
  6. WS3
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    WS3
    CAS: 1421227-52-2 PubChem CID: 72551586 Formula: C28H30F3N7O3 Molecular Weight: 569.58
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: W421557
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    Technical Identifiers
    IUPAC Name
    N-[6-[4-[[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide
    SMILES
    CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F
    InChIKey
    KIKOYRNAERIVSJ-UHFFFAOYSA-N
    InChI
    1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29,30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9show more
    Synonyms
    N-[6-[4-[[[[4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-amino]carbonyl]amino]phenoxy]-4-pyrimidinyl...
  7. WS6
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    WS6
    CAS: 1421227-53-3 PubChem CID: 71566751 Formula: C29H31F3N6O3 Molecular Weight: 568.59
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: W413752
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    Technical Identifiers
    IUPAC Name
    N-[6-[4-[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide
    SMILES
    CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)CC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F
    InChIKey
    FTODTDQFHDJWIQ-UHFFFAOYSA-N
    InChI
    1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3show more
    Synonyms
    CCG-270085 | AC-33128 | FT-0745267 | N-(6-(4-(2-((4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)...
  8. WS6
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    WS6
    CAS: 1421227-53-3 PubChem CID: 71566751 Formula: C29H31F3N6O3 Molecular Weight: 568.59
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: W421558
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    Technical Identifiers
    IUPAC Name
    N-[6-[4-[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide
    SMILES
    CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)CC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F
    InChIKey
    FTODTDQFHDJWIQ-UHFFFAOYSA-N
    InChI
    1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3show more
    Synonyms
    CCG-270085 | AC-33128 | FT-0745267 | N-(6-(4-(2-((4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)...
  9. XL019, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3
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    XL019, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3
    CAS: 945755-56-6 EC Number: 111-689-3 PubChem CID: 57990869 Formula: C25H28N6O2 Molecular Weight: 444.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: X427046
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    Technical Identifiers
    IUPAC Name
    (2S)-N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide
    SMILES
    C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
    InChIKey
    ISOCDPQFIXDIMS-QHCPKHFHSA-N
    InChI
    1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2show more
    Synonyms
    SCHEMBL4382715 | Lycoran-1.alpha., 3,3a-didehydro- | 4L1AM42NVA | MFCD24386874 | A859333 | SW219757-1 | 3,6,9,12,15,1...
  10. YMU1
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    YMU1
    CAS: 902589-96-2 PubChem CID: 49878590 Formula: C17H22N4O4S Molecular Weight: 378.45
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: Y412930
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    Technical Identifiers
    IUPAC Name
    ethyl 4-[2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetyl]piperazine-1-carboxylate
    SMILES
    CCOC(=O)N1CCN(CC1)C(=O)CN2C(=O)C3=C(S2)N=C(C=C3C)C
    InChIKey
    XXUFNNVFZFVKGP-UHFFFAOYSA-N
    InChI
    1S/C17H22N4O4S/c1-4-25-17(24)20-7-5-19(6-8-20)13(22)10-21-16(23)14-11(2)9-12(3)18-15(14)26-21/h9H,4-8,10H2,1-3H3
    Synonyms
    4-[2-(4,6-Dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-1-piperazinecarboxylic acid ethyl ester； Ethyl 4-(...
  11. ZD-4190
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    ZD-4190
    CAS: 413599-62-9 PubChem CID: 5329032 Formula: C19H16BrFN6O2 Molecular Weight: 459.27
    10mM in DMSO
    ● In Stock — US warehouse, ships to EU* Item #: Z423875
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    Technical Identifiers
    IUPAC Name
    N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine
    SMILES
    COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Br)F)OCCN4C=CN=N4
    InChIKey
    YBTGTVGEKMZEQX-UHFFFAOYSA-N
    InChI
    1S/C19H16BrFN6O2/c1-28-17-9-13-16(10-18(17)29-7-6-27-5-4-24-26-27)22-11-23-19(13)25-15-3-2-12(20)8-14(15)21/h2-5,8-11H,6-7H2,1H3,(H,22,23,25)
    Synonyms
    4-​Quinazolinamine,N-​(4-​bromo-​2-​fluorophenyl)​-​6-​methoxy-​7-​[2-​(1H-​1,​2,​3-​triazol-​1-​yl)​ethoxy]​-
  12. ZD-4190
    Wish List Compare
    ZD-4190
    CAS: 413599-62-9 PubChem CID: 5329032 Formula: C19H16BrFN6O2 Molecular Weight: 459.27
    ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: Z413512
    View Product
    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine
    SMILES
    COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Br)F)OCCN4C=CN=N4
    InChIKey
    YBTGTVGEKMZEQX-UHFFFAOYSA-N
    InChI
    1S/C19H16BrFN6O2/c1-28-17-9-13-16(10-18(17)29-7-6-27-5-4-24-26-27)22-11-23-19(13)25-15-3-2-12(20)8-14(15)21/h2-5,8-11H,6-7H2,1H3,(H,22,23,25)
    Synonyms
    4-​Quinazolinamine,N-​(4-​bromo-​2-​fluorophenyl)​-​6-​methoxy-​7-​[2-​(1H-​1,​2,​3-​triazol-​1-​yl)​ethoxy]​-
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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].
JAK/STAT signaling pages help researchers compare compounds relevant to cytokine signaling, transcriptional response, immune biology, and proliferative disease studies. Key evaluation points often include pathway node, isoform selectivity, upstream receptor context, cellular potency, biomarker response, and disease relevance. This category is useful when experiments need to connect receptor-level signaling with transcriptional outcomes across related pathway nodes. It supports both mechanism studies and discovery-stage compound selection.
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