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JAK/STAT Signaling

Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.

Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.

1,726 products
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EGFR

852

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JAK

448

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Pim

83

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STAT

418

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Showing 577-588 of 1,726

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  1. Broussonin E
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    Broussonin E
    CAS: 90902-21-9 PubChem CID: 14213544 Formula: C17H20O4 Molecular Weight: 288.34
    ≥98%
    ◐ .Made to order · 8–12 wks Item #: B648106
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    Technical Identifiers
    IUPAC Name
    5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol
    SMILES
    COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)OC)O)O
    InChIKey
    GDCSYNUJDYRGRF-UHFFFAOYSA-N
    InChI
    1S/C17H20O4/c1-20-14-8-7-13(15(18)11-14)5-3-4-12-6-9-17(21-2)16(19)10-12/h6-11,18-19H,3-5H2,1-2H3
  3. Itacitinib adipate
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    Itacitinib adipate
    CAS: 1334302-63-4 PubChem CID: 67390313 Formula: C32H33F4N9O5 Molecular Weight: 699.66
    ◐ .Made to order · 8–12 wks Item #: I648392
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    IUPAC Name
    2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrileshow more
    SMILES
    C1CN(CCC1N2CC(C2)(CC#N)N3C=C(C=N3)C4=C5C=CNC5=NC=N4)C(=O)C6=C(C(=NC=C6)C(F)(F)F)F.C(CCC(=O)O)CC(=O)O
    InChIKey
    CEGWJIQFBNFMHQ-UHFFFAOYSA-N
    InChI
    1S/C26H23F4N9O.C6H10O4/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-show more
    Synonyms
    A903004 | 1334302-63-4 | UNII-XZG407XE0Y | 3-azetidineacetonitrile,1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]ca...
  4. Arnicolide D
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    Arnicolide D
    CAS: 34532-68-8 PubChem CID: 182199 Formula: C19H24O5 Molecular Weight: 332.39
    ≥99%
    ◐ .Made to order · 8–12 wks Item #: A648414
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    Technical Identifiers
    IUPAC Name
    [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] 2-methylprop-2-enoate
    SMILES
    CC1CC2C(C(C(=O)O2)C)C(C3(C1C=CC3=O)C)OC(=O)C(=C)C
    InChIKey
    NZESEVTYUVXOTC-APDQSUQKSA-N
    InChI
    1S/C19H24O5/c1-9(2)17(21)24-16-15-11(4)18(22)23-13(15)8-10(3)12-6-7-14(20)19(12,16)5/h6-7,10-13,15-16H,1,8H2,2-5H3/t10-,11+,12+,13-,15-,16+,19+/m1/s1
    Synonyms
    Arnicolide D | ArnicolideD | (3aR)-4,4a,7aalpha,8,9,9aalpha-Hexahydro-4alpha-(methacryloyloxy)-3beta,4abeta,8alpha-tr...
  5. PACAP-38 (31-38), human, mouse, rat
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    PACAP-38 (31-38), human, mouse, rat
    CAS: 138764-85-9 PubChem CID: 139270272 Formula: C47H83N17O11 Molecular Weight: 1062.27
    ◐ .Made to order · 8–12 wks Item #: P648462
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    Technical Identifiers
    IUPAC Name
    N-[1-[[1-[[6-amino-1-[[4-amino-1-[(1,6-diamino-1-oxohexan-2-yl)amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]aminoshow more
    SMILES
    CC(C)C(C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CCCCN)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC1=CC=C(C=C1)O)N
    InChIKey
    YJQRDMBVNVOBLN-UHFFFAOYSA-N
    InChI
    1S/C47H83N17O11/c1-26(2)38(46(75)62-32(12-5-8-22-50)42(71)63-35(25-37(53)67)45(74)58-30(39(54)68)10-3-6-20-48)64-44(73)33(13-9-23-57-47(55)56)60-43(72show more
  6. (S)-Reticuline
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    (S)-Reticuline
    CAS: 485-19-8 EC Number: 207-611-3 Formula: C19H23NO4 Molecular Weight: 329.39
    Solid ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: R648486
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    Technical Identifiers
    IUPAC Name
    (1S)-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
    SMILES
    CN1CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)O)O)OC
    InChIKey
    BHLYRWXGMIUIHG-HNNXBMFYSA-N
    InChI
    1S/C19H23NO4/c1-20-7-6-13-10-19(24-3)17(22)11-14(13)15(20)8-12-4-5-18(23-2)16(21)9-12/h4-5,9-11,15,21-22H,6-8H2,1-3H3/t15-/m0/s1
    Synonyms
    BRN 4299976 | AKOS032948461 | CHEBI:16718 | Q6122828 | RETICULINE, (+)- | S-(+)-Reticuline | S-RETICULINE | (1S)-1-(3...
  7. EGFR-IN-8 - ≥98% CAS No(2407957-87-1) by Aladdin Scientific
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    EGFR-IN-8
    CAS: 2407957-87-1 PubChem CID: 139035057 Formula: C32H23ClF3N7O4 Molecular Weight: 662.02
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: E648596
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    Technical Identifiers
    IUPAC Name
    N-[3-chloro-4-[5-[3-[[4-(cyclopropanecarbonylamino)-3-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-1,2,4-oxadiazol-3-yl]phenyl]pyridine-3-carboxamidshow more
    SMILES
    C1CC1C(=O)NC2=C(C=C(C=C2)NC(=O)NC3=CC=CC(=C3)C4=NC(=NO4)C5=C(C=C(C=C5)NC(=O)C6=CN=CC=C6)Cl)C(F)(F)F
    InChIKey
    IIUNSVLRVWGJRM-UHFFFAOYSA-N
    InChI
    1S/C32H23ClF3N7O4/c33-25-15-22(38-29(45)19-4-2-12-37-16-19)8-10-23(25)27-42-30(47-43-27)18-3-1-5-20(13-18)39-31(46)40-21-9-11-26(24(14-21)32(34,35)36)show more
    Synonyms
    N-(3-Chloro-4-(5-(3-(3-(4-(cyclopropanecarboxamido)-3-(trifluoromethyl)phenyl)ureido)phenyl)-1,2,4-oxadiazol-3-yl)phe...
  8. Stafib-1
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    Stafib-1
    CAS: 1688703-26-5 PubChem CID: 122432036 Formula: C26H24N2O11P2 Molecular Weight: 602.42
    ≥95%
    ◐ .Made to order · 8–12 wks Item #: S648578
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    Technical Identifiers
    IUPAC Name
    [4-[[[2-[6-(phenylcarbamoyl)naphthalen-2-yl]oxyacetyl]amino]methyl]-2-phosphonooxyphenyl] dihydrogen phosphate
    SMILES
    C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=C2)C=C(C=C3)OCC(=O)NCC4=CC(=C(C=C4)OP(=O)(O)O)OP(=O)(O)O
    InChIKey
    SMUYYYBDKASIKY-UHFFFAOYSA-N
    InChI
    1S/C26H24N2O11P2/c29-25(27-15-17-6-11-23(38-40(31,32)33)24(12-17)39-41(34,35)36)16-37-22-10-9-18-13-20(8-7-19(18)14-22)26(30)28-21-4-2-1-3-5-21/h1-14Hshow more
  9. Tetramethylcurcumin
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    Tetramethylcurcumin
    CAS: 52328-97-9 PubChem CID: 11487078 Formula: C25H28O6 Molecular Weight: 424.49
    ≥99%
    ◐ .Made to order · 8–12 wks Item #: T648801
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    Technical Identifiers
    IUPAC Name
    (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione
    SMILES
    CC(C)(C(=O)C=CC1=CC(=C(C=C1)OC)OC)C(=O)C=CC2=CC(=C(C=C2)OC)OC
    InChIKey
    VMMZAMVBGQWOHT-UTLPMFLDSA-N
    InChI
    1S/C25H28O6/c1-25(2,23(26)13-9-17-7-11-19(28-3)21(15-17)30-5)24(27)14-10-18-8-12-20(29-4)22(16-18)31-6/h7-16H,1-6H3/b13-9+,14-10+
    Synonyms
    Tetramethylcurcumin | DTXSID70467449 | (1E,6E)-1,7-BIS(3,4-DIMETHOXYPHENYL)-4,4-DIMETHYLHEPTA-1,6-DIENE-3,5-DIONE | C...
  10. Tarlox-TKI - ≥97% CAS No(2135696-72-7) by Aladdin Scientific
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    Tarlox-TKI
    CAS: 2135696-72-7 PubChem CID: 51037658 Formula: C19H18BrClN6O Molecular Weight: 461.74
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ◐ .Made to order · 8–12 wks Item #: T648908
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    Technical Identifiers
    IUPAC Name
    (E)-N-[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)but-2-enamide
    SMILES
    CN(C)CC=CC(=O)NC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)Cl)Br
    InChIKey
    QBACGOWRJDBXSG-ONEGZZNKSA-N
    InChI
    1S/C19H18BrClN6O/c1-27(2)7-3-4-18(28)26-17-9-13-16(10-22-17)23-11-24-19(13)25-12-5-6-15(21)14(20)8-12/h3-6,8-11H,7H2,1-2H3,(H,22,26,28)(H,23,24,25)/b4show more
    Synonyms
    SCHEMBL11903013 | EX-A3689 | GTPL9410 | Kinase inhibitor-1 | (2E)-N-{4-[(3-bromo-4-chlorophenyl)amino]pyrido[3,4-d]py...
  11. Ilginatinib
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    Ilginatinib
    CAS: 1239358-86-1 PubChem CID: 46866319 Formula: C21H20FN7 Molecular Weight: 389.43
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US warehouse, ships to EU* Item #: I646262
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    IUPAC Name
    6-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methylpyrazol-4-yl)-2-N-pyrazin-2-ylpyridine-2,6-diamine
    SMILES
    CC(C1=CC=C(C=C1)F)NC2=CC(=CC(=N2)NC3=NC=CN=C3)C4=CN(N=C4)C
    InChIKey
    UQTPDWDAYHAZNT-AWEZNQCLSA-N
    InChI
    1S/C21H20FN7/c1-14(15-3-5-18(22)6-4-15)26-19-9-16(17-11-25-29(2)13-17)10-20(27-19)28-21-12-23-7-8-24-21/h3-14H,1-2H3,(H2,24,26,27,28)/t14-/m0/s1
    Synonyms
    N2-[(1S)-1-(4-Fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-2-pyrazinyl-2,6-pyridinediamine | GS-3039 | -N-[(1S...
  12. JAK1-IN-8 - CAS No(1973485-18-5) by Aladdin Scientific
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    JAK1-IN-8
    CAS: 1973485-18-5 PubChem CID: 122462620 Formula: C22H23FN4O3S Molecular Weight: 442.51
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ◐ .Made to order · 8–12 wks Item #: J646171
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    Technical Identifiers
    IUPAC Name
    N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide
    SMILES
    C1CC1C(=O)NC2=CN3C(=N2)C=CC=C3C4=CC(=C(C=C4)CN5CCS(=O)(=O)CC5)F
    InChIKey
    QDYVZZJCRDVVQG-UHFFFAOYSA-N
    InChI
    1S/C22H23FN4O3S/c23-18-12-16(6-7-17(18)13-26-8-10-31(29,30)11-9-26)19-2-1-3-21-24-20(14-27(19)21)25-22(28)15-4-5-15/h1-3,6-7,12,14-15H,4-5,8-11,13H2,(show more
    Synonyms
    N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide | KD...
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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].
JAK/STAT signaling pages help researchers compare compounds relevant to cytokine signaling, transcriptional response, immune biology, and proliferative disease studies. Key evaluation points often include pathway node, isoform selectivity, upstream receptor context, cellular potency, biomarker response, and disease relevance. This category is useful when experiments need to connect receptor-level signaling with transcriptional outcomes across related pathway nodes. It supports both mechanism studies and discovery-stage compound selection.
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