JAK/STAT Signaling

Explore compounds mapped to JAK/STAT signaling for cytokine biology, immune response research, and target validation. This category helps organize pathway modulators used in signaling studies, assay development, and translational discovery.

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  1. JAK2 JH2 Tracer
    CAS: 2101955-00-2 PubChem CID: 131704489 Formula: C38H27F2N7O6S Molecular Weight: 747.73
    ◐ .Made to order · 8–12 wks Item #: J648322
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    IUPAC Name
    1-[[4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]phenyl]methyl]-3-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)-1-methshow more
    SMILES
    CN(CC1=CC=C(C=C1)NC2=NN(C(=N2)N)C(=O)C3=C(C=CC=C3F)F)C(=S)NC4=CC5=C(C=C4)C6(C7=C(C=C(C=C7)O)OC8=C6C=CC(=C8)O)OC5=O
    InChIKey
    OAJQEPALUDJGLJ-UHFFFAOYSA-N
    InChI
    1S/C38H27F2N7O6S/c1-46(18-19-5-7-20(8-6-19)42-36-44-35(41)47(45-36)33(50)32-28(39)3-2-4-29(32)40)37(54)43-21-9-12-25-24(15-21)34(51)53-38(25)26-13-10-show more
  2. Stafib-2
    CAS: 2097938-74-2 PubChem CID: 129896883 Formula: C28H26N2O12P2 Molecular Weight: 644.46
    ◐ .Made to order · 8–12 wks Item #: S648231
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    IUPAC Name
    [4-[[[2-[4-[(4-phenoxyphenyl)carbamoyl]phenoxy]acetyl]amino]methyl]-2-phosphonooxyphenyl] dihydrogen phosphate
    SMILES
    C1=CC=C(C=C1)OC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)OCC(=O)NCC4=CC(=C(C=C4)OP(=O)(O)O)OP(=O)(O)O
    InChIKey
    LJGIDZSIOSYQMR-UHFFFAOYSA-N
    InChI
    1S/C28H26N2O12P2/c31-27(29-17-19-6-15-25(41-43(33,34)35)26(16-19)42-44(36,37)38)18-39-22-11-7-20(8-12-22)28(32)30-21-9-13-24(14-10-21)40-23-4-2-1-3-5-show more
    Synonyms
    4-((2-(4-((4-Phenoxyphenyl)carbamoyl)phenoxy)acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate) | HY-112648 | ...
  3. Rociletinib hydrobromide
    CAS: 1446700-26-0 PubChem CID: 71725151 Formula: C27H29BrF3N7O3 Molecular Weight: 636.46
    ◐ .Made to order · 8–12 wks Item #: R648478
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    SMILES
    CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC.Br
  4. RO8191
    CAS: 691868-88-9 EC Number: 809-506-3 PubChem CID: 2768133 Formula: C14H5F6N5O Molecular Weight: 373.21
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: R648334
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    IUPAC Name
    2-[2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridin-8-yl]-1,3,4-oxadiazole
    SMILES
    C1=CC2=NC(=CN2C3=C1C(=CC(=N3)C(F)(F)F)C(F)(F)F)C4=NN=CO4
    InChIKey
    GRHYZVJEXKTJOS-UHFFFAOYSA-N
    InChI
    1S/C14H5F6N5O/c15-13(16,17)7-3-9(14(18,19)20)23-11-6(7)1-2-10-22-8(4-25(10)11)12-24-21-5-26-12/h1-5H
    Synonyms
    F77218 | NCGC00408901-01 | AKOS005079117 | MixCom2_000289 | 2-(2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridi...
  5. Stafia-1-dipivaloyloxymethyl ester
    CAS: 2582755-72-2 PubChem CID: 146681210 Formula: C37H48FO13P Molecular Weight: 750.74
    ◐ .Made to order · 8–12 wks Item #: S648373
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    IUPAC Name
    [[[3,5-bis(3,4,5-trimethoxyphenyl)phenyl]-fluoromethyl]-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
    SMILES
    CC(C)(C)C(=O)OCOP(=O)(C(C1=CC(=CC(=C1)C2=CC(=C(C(=C2)OC)OC)OC)C3=CC(=C(C(=C3)OC)OC)OC)F)OCOC(=O)C(C)(C)C
    InChIKey
    WWHLAYKEMWWVIA-UHFFFAOYSA-N
    InChI
    1S/C37H48FO13P/c1-36(2,3)34(39)48-20-50-52(41,51-21-49-35(40)37(4,5)6)33(38)26-14-22(24-16-27(42-7)31(46-11)28(17-24)43-8)13-23(15-26)25-18-29(44-9)32show more
  6. Corylifol A
    CAS: 775351-88-7 PubChem CID: 25056407 Formula: C25H26O4 Molecular Weight: 390.47
    ◐ .Made to order · 8–12 wks Item #: C648628
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    IUPAC Name
    3-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-4-hydroxyphenyl]-7-hydroxychromen-4-one
    SMILES
    CC(=CCCC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C)C
    InChIKey
    ZBHUUXLHDOUMKM-REZTVBANSA-N
    InChI
    1S/C25H26O4/c1-16(2)5-4-6-17(3)7-8-19-13-18(9-12-23(19)27)22-15-29-24-14-20(26)10-11-21(24)25(22)28/h5,7,9-15,26-27H,4,6,8H2,1-3H3/b17-7+
    Synonyms
    AKOS032948982 | MS-26509 | 3-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-4-hydroxyphenyl]-7-hydroxychromen-4-one | Corylini...
  7. Ilginatinib hydrochloride
    CAS: 1239358-85-0 PubChem CID: 89571724 Formula: C21H21ClFN7 Molecular Weight: 425.89
    ◐ .Made to order · 8–12 wks Item #: I649125
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    IUPAC Name
    6-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methylpyrazol-4-yl)-2-N-pyrazin-2-ylpyridine-2,6-diamine;hydrochloride
    SMILES
    CC(C1=CC=C(C=C1)F)NC2=CC(=CC(=N2)NC3=NC=CN=C3)C4=CN(N=C4)C.Cl
    InChIKey
    XFNVGPXGVAXXSH-UQKRIMTDSA-N
    InChI
    1S/C21H20FN7.ClH/c1-14(15-3-5-18(22)6-4-15)26-19-9-16(17-11-25-29(2)13-17)10-20(27-19)28-21-12-23-7-8-24-21;/h3-14H,1-2H3,(H2,24,26,27,28);1H/t14-;/m0show more
  8. Garcinone C
    CAS: 76996-27-5 PubChem CID: 44159808 Formula: C23H26O7 Molecular Weight: 414.45
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ◐ .Made to order · 8–12 wks Item #: G648942
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    IUPAC Name
    1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methylbut-2-enyl)xanthen-9-one
    SMILES
    CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)O)CCC(C)(C)O)O)C
    InChIKey
    HLOCLVMUASBDDP-UHFFFAOYSA-N
    InChI
    1S/C23H26O7/c1-11(2)5-6-12-14(24)9-17-19(21(12)27)22(28)18-13(7-8-23(3,4)29)20(26)15(25)10-16(18)30-17/h5,9-10,24-27,29H,6-8H2,1-4H3
    Synonyms
    1,3,6,7-TETRAHYDROXY-8-(3-HYDROXY-3-METHYLBUTYL)-2-(3-METHYLBUT-2-EN-1-YL)-9H-XANTHEN-9-ONE | CHEBI:175308 | MS-27173...
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Frequently Asked Questions

What should I consider when selecting a JAK/STAT Signaling product?
Define the transformation first, then narrow the JAK/STAT Signaling listing by reactivity, compatibility with your solvent and temperature window, and scale. Where several grades exist, the higher-purity option is usually worth it for downstream steps that are hard to purify.
Which JAK/STAT Signaling subcategory should I start with?
JAK/STAT Signaling is organised into EGFR, JAK, Pim and STAT. Pick the subcategory that matches the structural motif or reaction class you need; compounds that fit more than one are cross-listed.
Which quality data should I check before ordering JAK/STAT Signaling?
Review the lot-specific Certificate of Analysis for the JAK/STAT Signaling product you have chosen: assay or HPLC purity, identity confirmation by NMR and MS, residual solvents where relevant, and appearance. For reactive or hygroscopic material the storage and handling notes matter as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search JAK/STAT Signaling by structure or CAS number?
Yes. Within JAK/STAT Signaling you can search by CAS number, molecular formula, or SMILES to reach exact structures and close analogs, and filter by functional group, purity grade, and pack size. For pricing, bulk quantities, or account eligibility, contact [email protected].

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